Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Donald T, Moir"'
Autor:
Terry L. Bowlin, Donald T. Moir, Michelle M. Butler, James C. Burnett, Bing Li, Norton P. Peet
Publikováno v:
Molecules, Vol 16, Iss 1, Pp 202-220 (2010)
Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, le
Externí odkaz:
https://doaj.org/article/d719bdd325de4d4b8f36262565b81756
Publikováno v:
Drug discovery today. 26(9)
The increasing prevalence of multidrug-resistant (MDR) bacterial infections has created a crucial need for new therapeutics that avoid or minimize existing resistance mechanisms. In this review, we describe the development of novel classes of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84f4c5a829015ecb4d8140706acacb4
https://pubmed.ncbi.nlm.nih.gov/33845218
https://pubmed.ncbi.nlm.nih.gov/33845218
Autor:
Jen-I Mao, Donald T. Moir
Secretion is an attractive production mode for proteins that require posttranslational modifications carried out in the secretory pathway. For example, amino acid chains fold properly, disulfide bonds form correctly, and glycosylation occurs accurate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f65dcb3994af5e49443720a7e30135
https://doi.org/10.1201/9781003066392-5
https://doi.org/10.1201/9781003066392-5
Autor:
Jaden Yabut, Donald T. Moir, Bryan J. Berube, Alan R. Hauser, Zachary D. Aron, Terry L. Bowlin, John D. Williams, Giang T. Nguyen, Nicholas O. Bowlin, Debra M. Mills, Joan Mecsas
Publikováno v:
Journal of Bacteriology. 202
The Pseudomonas aeruginosa type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c45991ca7b0f3d0c0e6b2ebbabbf31
https://doi.org/10.1128/jb.00055-20
https://doi.org/10.1128/jb.00055-20
Autor:
Donald T, Moir, Nicholas O, Bowlin, Bryan J, Berube, Jaden, Yabut, Debra M, Mills, Giang T, Nguyen, Zachary D, Aron, John D, Williams, Joan, Mecsas, Alan R, Hauser, Terry L, Bowlin
Publikováno v:
J Bacteriol
The Pseudomonas aeruginosa type III secretion system (T3SS) needle comprised of multiple PscF subunits is essential for the translocation of effector toxins into human cells, facilitating the establishment and dissemination of infection. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6ed1fe63674897a027a32524ae665ec
https://pubmed.ncbi.nlm.nih.gov/32601072
https://pubmed.ncbi.nlm.nih.gov/32601072
Autor:
Britney Johnson, Christopher F. Basler, Peter J. Nash, Gaya K. Amarasinghe, Ma. Xenia G. Ilagan, Daisy W. Leung, Donald T. Moir, Gai Liu, Alexander Bukreyev, Colette Pietzsch, Terry L. Bowlin
Publikováno v:
ACS Infectious Diseases. 3:190-198
The 2014 Ebola outbreak in West Africa, the largest outbreak on record, highlighted the need for novel approaches to therapeutics targeting Ebola virus (EBOV). Within the EBOV replication complex, the interaction between polymerase cofactor, viral pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5017b3f3a6a93dce7ffe5a5a335638
https://doi.org/10.1021/acsinfecdis.6b00209
https://doi.org/10.1021/acsinfecdis.6b00209
Publikováno v:
Clinical Infectious Diseases. 63:89-95
The utility of conventional antibiotics for the treatment of bacterial infections has become increasingly strained due to increased rates of resistance coupled with reduced rates of development of new agents. As a result, multidrug-resistant, extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe59742eae8df365b80ff22b15f9d0f
https://doi.org/10.1093/cid/ciw200
https://doi.org/10.1093/cid/ciw200
Autor:
Panatda Saenkham, Steven M. Kwasny, Timothy J. Opperman, Donald T. Moir, Terry L. Bowlin, Charles O. Rock, John D. Williams, Debra M. Mills, Joselynn R. Wallace, Nicholas O. Bowlin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:5775-5787
Novel, cellular, gain-of-signal, bioluminescent reporter assays for fatty acid synthesis type II (FASII) inhibitors were constructed in an efflux-deficient strain of Pseudomonas aeruginosa and based on the discovery that FASII genes in P. aeruginosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acca0fd70bf12f47059a0e9bea8ed83
https://doi.org/10.1128/aac.00686-15
https://doi.org/10.1128/aac.00686-15
Autor:
Jean L. Patterson, Daniel Mitchell, John M. Dye, Donald T. Moir, Lijun Rong, Arnab Basu, Debra M. Mills, John D. Williams, Esther Ndungo, Andrew S. Herbert, Kartik Chandran, Terry L. Bowlin
Publikováno v:
Journal of Infectious Diseases. 212:S425-S434
Background. The current Ebola virus (EBOV) outbreak has highlighted the troubling absence of available antivirals or vaccines to treat infected patients and stop the spread of EBOV. The EBOV glycoprotein (GP) plays critical roles in the early stage o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227dfb30c1005f7edffd116c5117c133
https://doi.org/10.1093/infdis/jiv223
https://doi.org/10.1093/infdis/jiv223
Autor:
John D. Williams, Kathy A. Keith, Dale L. Barnard, Peter J. Nash, Arnab Basu, Jessica A. Ames, Norton P. Peet, Terry L. Bowlin, Lijun Rong, Bing Li, Donald T. Moir, Minxiu Wang, Mark N. Prichard, Michael Caffrey, Aleksandar Antanasijevic, Debra M. Mills
Publikováno v:
Journal of Virology
Influenza viruses are a major public health threat worldwide, and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The influenza virus glycoprotein hemagglutinin (HA) plays critical roles in the early stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81b18f9daf3d236ab77b90b4b795670