Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Donald S. Williams"'
Autor:
Antonio Cabal, Donald S. Williams, Richa Y. Jayakar, Jingru Zhang, Swanand Sardesai, Le T. Duong
Publikováno v:
Bone Reports, Vol 6, Iss C, Pp 26-33 (2017)
The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treat
Externí odkaz:
https://doaj.org/article/f928a5ab9cbe4d71bb8d918e6d7b3bf4
Autor:
Stephanie Seah, Abu Bakar Ali Asad, Richard Baumgartner, Dai Feng, Donald S Williams, Elaine Manigbas, John D Beaver, Torsten Reese, Brian Henry, Jeffrey L Evelhoch, Chih-Liang Chin
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110432 (2014)
BACKGROUND: Pharmacological MRI (phMRI) is a neuroimaging technique where drug-induced hemodynamic responses can represent a pharmacodynamic biomarker to delineate underlying biological consequences of drug actions. In most preclinical studies, anima
Externí odkaz:
https://doaj.org/article/b64f07d05c404274a1dca2bd473850b4
Autor:
Xiaohai Wang, Donald S. Williams, Jeffrey L. Evelhoch, Hatim A. Zariwala, Christopher T. Winkelmann, Andrea K. Houghton, Fuqiang Zhao, Jason M. Uslaner
Publikováno v:
NeuroImage. 127:445-455
Cerebral blood volume (CBV) fMRI with ultrasmall superparamagnetic iron oxide particles (USPIO) as a contrast agent was used to investigate olfactory processing in rats. fMRI data were acquired in sixteen 0.75-mm coronal slices covering the olfactory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91443f506399b8ffd8d6806821da54b1
https://doi.org/10.1016/j.neuroimage.2015.10.080
https://doi.org/10.1016/j.neuroimage.2015.10.080
Autor:
Le T. Duong, Donald S. Williams, Antonio Cabal, Jingru Zhang, Richa Y. Jayakar, Swanand Sardesai
Publikováno v:
Bone Reports
Bone Reports, Vol 6, Iss C, Pp 26-33 (2017)
Bone Reports, Vol 6, Iss C, Pp 26-33 (2017)
The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb0cd8c36d7fdf223445dde985ff343
Autor:
Antonio Cabal, Sherri L. Motzel, Bernard J. Dardzinski, Le T. Duong, Parker D. Mathers, Lynn Cook, Alan T. Savitz, Diane Posavec, Swanand Sardesai, Christopher T. Winkelmann, Donald S. Williams, Thomas N. Hangartner, Eual A. Phillips, Paul J. McCracken, Richa Y. Jayakar, John Szumiloski, Boyd B. Scott, Richard Hargreaves, Jeffrey L. Evelhoch
Publikováno v:
Bone. 56:497-505
Translational evaluation of disease progression and treatment response is critical to the development of therapies for osteoporosis. In this study, longitudinal in-vivo monitoring of odanacatib (ODN) treatment efficacy was compared to alendronate (AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5673d42c6a220df65d098456e6e872e4
https://doi.org/10.1016/j.bone.2013.06.011
https://doi.org/10.1016/j.bone.2013.06.011
Autor:
Eual A. Phillips, Richa Y. Jayakar, Donald S. Williams, Thomas N. Hangartner, Maureen Pickarski, Christopher T. Winkelmann, Swanand Sardesai, Richard Hargreaves, Boyd B. Scott, John Szumiloski, Antonio Cabal, Andres Laib, Paul J. McCracken, Le T. Duong
Publikováno v:
Bone. 50:1379-1388
This study aimed to validate finite element analysis (FEA) estimation of strength, identify high-resolution peripheral quantitative computed tomography (HR-pQCT) measures correlating with strength, and evaluate the precision of HR-pQCT measurements t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0307415312aa0f7edaba3f3775bae8b
https://doi.org/10.1016/j.bone.2012.03.017
https://doi.org/10.1016/j.bone.2012.03.017
Autor:
Donald S. Williams, Denise C. Welsh, Mark O. Urban, Fuqiang Zhao, Richard Hargreaves, Alexandre Coimbra, Mangay Williams, Jeffrey L. Evelhoch
Publikováno v:
NeuroImage. 59:1168-1179
This study aims to identify fMRI signatures of nociceptive processing in whole brain of anesthetized rats during noxious electrical stimulation (NES) and noxious mechanical stimulation (NMS) of paw. Activation patterns for NES were mapped with blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5181a6889d47bd7c24d7421a8fa2140f
https://doi.org/10.1016/j.neuroimage.2011.08.002
https://doi.org/10.1016/j.neuroimage.2011.08.002
Autor:
Jacob M. Elkins, Donald S. Williams, L. T. Duong, Alexandre Coimbra, Punam K. Saha, Guoyuan Liang, Milan Sonka
Publikováno v:
IEEE Transactions on Biomedical Engineering. 58:2212-2227
Osteophyte is an additional bony growth on a normal bone surface limiting or stopping motion at a deteriorating joint. Detection and quantification of osteophytes from computed tomography (CT) images is helpful in assessing disease status as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf3ec22bc59b77ce2fb49671fa0f964
https://doi.org/10.1109/tbme.2011.2129519
https://doi.org/10.1109/tbme.2011.2129519
Autor:
Donald S. Williams, Denise C. Welsh, Mangay Williams, Catherine Abbadie, Amy M. Ritter, Richard Hargreaves, Xiangjun Meng, Fuqiang Zhao, Alise S. Reicin, Jacquelynn J. Cook
Publikováno v:
Pain. 145:110-119
Spinal cord fMRI offers an excellent opportunity to quantify nociception using neuronal activation induced by painful stimuli. Measurement of the magnitude of stimulation-induced activation, and its suppression with analgesics can provide objective m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53329d67d743b8b9eb87a0a342a4e515
https://doi.org/10.1016/j.pain.2009.05.026
https://doi.org/10.1016/j.pain.2009.05.026
Autor:
Richard Hargreaves, Xiangjun Meng, Mangay Williams, Igor D. Grachev, Donald S. Williams, Denise C. Welsh, Fuqiang Zhao
Publikováno v:
NeuroImage. 44:349-362
Objective measure of pain is valuable in drug discovery research and development of analgesics. Spinal cord is an important relay of the pain pathway, and fMRI offers an excellent opportunity to quantify pain using activation in the spinal cord induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf2890378587e853d448c6bd78dbba5
https://doi.org/10.1016/j.neuroimage.2008.09.001
https://doi.org/10.1016/j.neuroimage.2008.09.001