Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Donald S. Higgins"'
Autor:
Richard F. Seegal, Kenneth L. Marek, John P. Seibyl, Danna L. Jennings, Eric S. Molho, Donald S. Higgins, Stewart A. Factor, Edward F. Fitzgerald, Elaine A. Hills, Susan A. Korrick, Mary S. Wolff, Richard F. Haase, Andrew C. Todd, Patrick Parsons, Robert J. McCaffrey
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 2, Pp 219-225 (2010)
We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [123I]β-CIT SPECT imaging to estim
Externí odkaz:
https://doaj.org/article/7d48a47f43104559b6da08d5180d95c5
Publikováno v:
Medical care. 60(8)
It is well known that 20% of the patients incur 80% of health care costs and many diseases and complications can be prevented or ameliorated with prompt intervention. One of the well-recognized strategies for cost reduction and better outcomes is to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6fbbb20139e8ae2f05ae888035591
https://pubmed.ncbi.nlm.nih.gov/35640025
https://pubmed.ncbi.nlm.nih.gov/35640025
Autor:
Robert J. Ringer, Katherine J. Hill, Domenic J. Reda, Tamara Paine, Jonathan R. Wolpaw, Charles S. Carmack, Grant D. Huang, Huned S. Patwa, Dennis J. McFarland, Susan M. Heckman, Robert L. Ruff, Richard Bedlack, Eric W. Sellers, Theresa M. Vaughan, Patricia G. Banks, Albert C. Lo, Donald S. Higgins, Lynn M. McCane, Stefan Winden, Hairong Shi
Publikováno v:
Neurology. 91:e258-e267
ObjectiveTo assess the reliability and usefulness of an EEG-based brain-computer interface (BCI) for patients with advanced amyotrophic lateral sclerosis (ALS) who used it independently at home for up to 18 months.MethodsOf 42 patients consented, 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3056859d016b8cdbc531c7cdc37dff3
https://doi.org/10.1212/wnl.0000000000005812
https://doi.org/10.1212/wnl.0000000000005812
Autor:
Jagan A. Pillai, Christopher A. Ross, Randi Jones, Donald S. Higgins, Hannah M. Tully, Charles Nichter, Peter K. Panegyres, Stewart A. Factor, Leslie J. Cloud, Russel L. Margolis, Adam Rosenblatt, Claudia M. Testa, Sandra L. Helmers, Jody Corey-Bloom, Thomas D. Bird
Publikováno v:
Movement Disorders. 27:1797-1800
Little is known about the epilepsy that often occurs in the juvenile form of Huntington's disease (HD), but is absent from the adult-onset form. The primary aim of this study was to characterize the seizures in juvenile HD (JHD) subjects with regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7acd357856174a5a3aafeb8f46f778d1
https://doi.org/10.1002/mds.25237
https://doi.org/10.1002/mds.25237
Autor:
Eric Molho, N. Kyle Steenland, Donald S. Higgins, Cyrus P. Zabetian, Denise M. Kay, Haydeh Payami, Jennifer S. Montimurro, Ami Rosen, Stewart A. Factor
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 82:564-568
Objective To test the hypothesis that postural instability with falling (PIF) and freezing of gait (FOG) are distinct subtypes of the postural instability/gait disturbance (PIGD) form of Parkinson9s disease (PD). Methods 499 PD subjects from the Neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c059b0fedaad4160302ff602baa271be
https://doi.org/10.1136/jnnp.2010.222042
https://doi.org/10.1136/jnnp.2010.222042
Autor:
Stewart A. Factor, Denise M. Kay, Haydeh Payami, Jennifer S. Montimurro, J. G. Nutt, Parvoneh Poorkaj, Lina M. Moses, C. Stevens, Alida Griffith, Gerard D. Schellenberg, Eric Molho, Taye H. Hamza, Thomas D. Bird, John W. Roberts, S. Zareparsi, Donald S. Higgins, S. T. Gancher, Cyrus P. Zabetian, Ali Samii
Publikováno v:
Neurology. 75:1189-1194
Objectives: To perform a comprehensive population genetic study of PARK2 . PARK2 mutations are associated with juvenile parkinsonism, Alzheimer disease, cancer, leprosy, and diabetes mellitus, yet ironically, there has been no comprehensive study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38fa1df554cc33a2e3760f275709113
https://doi.org/10.1212/wnl.0b013e3181f4d832
https://doi.org/10.1212/wnl.0b013e3181f4d832
Autor:
Danna Jennings, Donald S. Higgins, Eric Molho, Richard F. Seegal, Kenneth Marek, Richard F. Haase, Andrew C. Todd, John Seibyl, Elaine A. Hills, Mary S. Wolff, Patrick J. Parsons, Stewart A. Factor, Robert J. McCaffrey, Edward F. Fitzgerald
Publikováno v:
Journal of Exposure Science & Environmental Epidemiology. 21:234-246
To date, most estimates of the half-life of polychlorinated biphenyls (PCBs) in humans have been based on relatively short follow-up periods. To address this issue, we determined the half-lives of PCB congeners of occupational origin in the serum of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb15cffc8092166ec2cf5dbccfe53a3
https://doi.org/10.1038/jes.2010.3
https://doi.org/10.1038/jes.2010.3
Publikováno v:
Movement Disorders. 24:1384-1387
Using a structured interview method, we sought to address the following questions regarding cervical dystonia (CD) and employment: (1) what is the frequency and severity of job impairment in CD; (2) what are the clinical features that contribute to j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd3b7318e7df7d8be4832a00addcf095
https://doi.org/10.1002/mds.22622
https://doi.org/10.1002/mds.22622
Autor:
Denise M. Kay, Donald S. Higgins, Robert G. Keefe, Berta C. Leis, John W. Roberts, April J. Atkins, Dora Yearout, Ali Samii, Haydeh Payami, Alida Griffith, Jennifer S. Montimurro, Cyrus P. Zabetian, Stewart A. Factor, John G. Nutt
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :1222-1230
Point mutations and copy number variations in SNCA, the gene encoding alpha-synuclein, cause familial Parkinson's disease (PD). A dinucleotide polymorphism (REP1) in the SNCA promoter may be a risk factor for common forms of PD. We studied 1,802 PD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af3cd3fcb04b3ce603ddb8e5643a6e6
https://doi.org/10.1002/ajmg.b.30758
https://doi.org/10.1002/ajmg.b.30758
Publikováno v:
Journal of Neurochemistry. 75:2611-2621
Defects in mitochondrial energy metabolism have been implicated in several neurodegenerative disorders. Defective complex I (NADH:ubiquinone oxidoreductase) activity plays a key role in Leber's hereditary optic neuropathy and, possibly, Parkinson's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4100f1369f5fad475f35f4d45f691995
https://doi.org/10.1046/j.1471-4159.2000.0752611.x
https://doi.org/10.1046/j.1471-4159.2000.0752611.x