Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Donald S. Davies"'
Autor:
Rumana Z Omar, Jane Key, Paul Elliott, Tina Kold Jensen, Simon G. Thompson, Donald S. Davies, Alan R. Boobis, Susan Hodgson
Publikováno v:
Key, J, Hodgson, S, Omar, R Z, Jensen, T K, Thompson, S G, Boobis, A R, Davies, D S & Elliott, P 2006, ' Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. ', Cancer Causes & Control, vol. 17, pp. 759-770 . https://doi.org/10.1007/s10552-006-0011-0
To give an up-to-date assessment of the association of alcohol with female breast cancer, addressing methodological issues and shortfalls in previous overviews.Meta-analysis of studies (any language) providing original data on incidence of first prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14260bcc357a79b0aa3442451cb9e5e4
https://doi.org/10.1007/s10552-006-0011-0
https://doi.org/10.1007/s10552-006-0011-0
Autor:
Donald S. Davies, Sunil Shaunak
Publikováno v:
British Journal of Clinical Pharmacology. 54:75-80
The coming of age of molecular biology has resulted in an explosion in our understanding of the pathogenesis of virus related diseases. New pathogens have been identified and characterized as being responsible for old diseases. Empirical clinical eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcd0f6650c290805c5d2d15d50c3dff
https://doi.org/10.1046/j.1365-2125.2002.01623.x
https://doi.org/10.1046/j.1365-2125.2002.01623.x
This supplement presents the papers submitted at the 27th meeting of the European Society of Toxicology, which was organised by the British Toxicology Society and held in Harrogate, England. As evident from the title of this book, the overall theme o
Autor:
Shinichi Kobayashi, Donald S. Davies, Khadija Debri, Hironori Nakura, Patrick J Brassil, Robert Edwards
Publikováno v:
Biochemical Pharmacology. 56:253-257
A strain of hyperlipidaemic Sprague-Dawley (HSD) rat was compared with normal Sprague-Dawley (SD) rats for expression of cholesterol 7alpha-hydroxylase activity (CYP7A1) and other cytochrome P450 (P450) enzymes in liver. Hepatic microsomal CYP7A1 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e6958ff11bd00d3a91e8c13a79d020
https://doi.org/10.1016/s0006-2952(98)00015-x
https://doi.org/10.1016/s0006-2952(98)00015-x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1382:287-294
CYP2E1 is the main enzyme responsible for chlorzoxazone 6-hydroxylase activity in human liver. Here, it is shown that marmoset monkey liver microsomal fraction catalyses this reaction at a similar rate and with a similar K m to human liver and that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390ab2d9393cbe68b8520611c7422f69
https://doi.org/10.1016/s0167-4838(97)00170-2
https://doi.org/10.1016/s0167-4838(97)00170-2
Publikováno v:
Biochemical Pharmacology. 54:189-197
The structural similarity of related forms of P450 makes selective immunoinhibition of individual forms notoriously difficult to achieve. We report the use of a targeted antibody to overcome this problem. An antibody was raised against the synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6ce48c788eee6fef267794eed271c8
https://doi.org/10.1016/s0006-2952(97)00167-6
https://doi.org/10.1016/s0006-2952(97)00167-6
Autor:
Alan R. Boobis, Donald S. Davies, Masoud Yadollahi-Farsani, Nigel J. Gooderham, K. Zhao, Stephen Murray, K. J. Rich, Anthony M. Lynch
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 376:53-60
Heterocyclic amines such as MeIQx and PhIP are potent genotoxic chemicals which are formed at part per billion levels when meat is cooked. Using assays based on gas chromatography/mass spectrometry with stable isotope labelled analogues as internal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702b922fad91b907210b9f3f690ee322
https://doi.org/10.1016/s0027-5107(97)00025-0
https://doi.org/10.1016/s0027-5107(97)00025-0
Publikováno v:
British Journal of Clinical Pharmacology. 42:81-89
1The role that P450 plays in the metabolism of drugs and other chemicals is often pivotal in determining the duration and magnitude of their biological effects, so that it is important to identify the specific forms of the enzyme involved. 2The simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b43cf54fe431a98a431a4947a97003
https://doi.org/10.1046/j.1365-2125.1996.37912.x
https://doi.org/10.1046/j.1365-2125.1996.37912.x
Autor:
C. Bratt, S. J. Crosbie, S. Bhadresa, Nigel J. Gooderham, K. Zhao, Stephen Murray, Donald S. Davies, Anthony M. Lynch, Masoud Yadollahi-Farsani, K. J. Rich, Alan R. Boobis, Bernard P. Murray, Robert J. Edwards
Publikováno v:
British Journal of Clinical Pharmacology. 42:91-98
1Heterocyclic amines are formed in parts per billion levels when meat is cooked. 2The heterocyclic amines MeIQx and PhIP are efficiently absorbed into the systemic circulation after ingestion of cooked food. 3We have shown that MeIQx and PhIP, both i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de8fb9e49ec0b5feaff4c20429d2b58
https://doi.org/10.1046/j.1365-2125.1996.37513.x
https://doi.org/10.1046/j.1365-2125.1996.37513.x
Publikováno v:
Carcinogenesis. 17:617-624
The mutagenic 'fingerprint' of the cooked food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was determined in a Chinese hamster cell line genetically engineered to express human CYP1A2 (XEMh1A2-MZ). The parental Chinese hamster V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e5631506ef8379f6c8fa4255e8082a
https://doi.org/10.1093/carcin/17.4.617
https://doi.org/10.1093/carcin/17.4.617