Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Donald S. Anson"'
Autor:
Donald S. Anson, Yazad Irani, Douglas G.A. Parker, Lucas M. Bachmann, Lauren A. Mortimer, Claude Kaufmann, Keryn A. Williams, Helen M. Brereton
Publikováno v:
Current Eye Research. 42:1426-1434
To evaluate the gene transfer of the interleukin (IL)-10 cytokine as a treatment modality for prolonging limbal allograft survival in a rat model.Adenoviral (AV) and lentiviral (LV) vectors were produced for ex vivo gene transfer into limbal graft ti
Publikováno v:
Molecular Genetics and Metabolism. 101:370-382
Mucopolysaccharidosis type VII (MPS VII) is caused by the deficiency of the lysosomal hydrolase β-glucuronidase. Symptoms include intellectual impairment, growth retardation, visual and hearing deficits and organ malfunction. The MPS VII mouse displ
Publikováno v:
The Journal of Gene Medicine. 12:717-728
Background The hallmark of lysosomal storage disorders (LSDs) is microscopically demonstrable lysosomal distension. In mucopolysaccharidosis type IIIA (MPS IIIA), this occurs as a result of an inherited deficiency of the lysosomal hydrolase sulphamid
Autor:
Douglas J. Coster, Helen M. Brereton, Prue H. Hart, Douglas G.A. Parker, Donald S. Anson, Rachel Koldej, Keryn A. Williams
Publikováno v:
Clinical & Experimental Ophthalmology. 38:405-413
Douglas G. Parker, Douglas J. Coster, Helen M. Brereton, Prue H. Hart, Rachel Koldej, Donald S. Anson and Keryn A. Williams
Autor:
David Parsons, Darren S Miller, Alice G. Stocker, Karlea L. Kremer, Donald S. Anson, Rachel Koldej
Publikováno v:
The Journal of Gene Medicine. 11:861-867
BACKGROUND: Cystic fibrosis (CF) is caused by a defect in cystic fibrosis transmembrane conductance regulator (CFTR) activity, often resulting in an incurable airway disease. Gene therapy into the conducting airway epithelium is a potential cure for
Autor:
Ainslie Derrick Roberts, Marleesa Ly, Sharon Byers, Donald S. Anson, Xenia Kaidonis, Wan Chin Liaw
Publikováno v:
European Journal of Human Genetics. 18:194-199
Neurological pathology is characteristic of the mucopolysaccharidoses (MPSs) that store heparan sulphate (HS) glycosaminoglycan (gag) and has been proven to be refractory to systemic therapies. Substrate deprivation therapy (SDT) using general inhibi
Publikováno v:
Molecular Genetics and Metabolism. 97:102-108
Joint disease in mucopolysaccharidosis type VI (MPS VI) remains difficult to treat despite the success of enzyme replacement therapy in treating other symptoms. In this study, the efficacy of a lentiviral vector to transduce joint tissues and express
Autor:
Donald S. Anson, Doug Parker, Claire F. Jessup, Claude Kaufmann, L Francis-Staite, Rachel Koldej, Keryn A. Williams, K Marshall, C Tan, Douglas J. Coster, Helen M. Brereton
Publikováno v:
Gene Therapy. 14:760-767
Gene therapy of the cornea shows promise for modulating corneal transplant rejection but the most appropriate vector for gene transfer has yet to be determined. We investigated a lentiviral vector (LV) for its ability to transduce corneal endothelium
Publikováno v:
Current Gene Therapy. 6:161-179
Cystic fibrosis (CF) was one of the first inherited disorders for which gene therapy was seriously considered as a realistic option for treatment, and as such, it has long provided a paradigm for gene therapy of inherited diseases. However, despite t
Autor:
Donald S. Anson, Kylie R. Dunning
Publikováno v:
Molecular Biotechnology. 31:085-088
We have constructed reading frames for the HIV-1 YU-2 minor proteins Vpr, Vpu, Vif and Nef that are codon-optimized for high-level expression in mammalian cells. We show that, in the absence of the Rev/Rev-response element system, these codon-optimiz