Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Donald Ruhrmund"'
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e526d623aa25a82e039d51bfe79da1d8
https://doi.org/10.1128/aac.01569-16
https://doi.org/10.1128/aac.01569-16
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd
https://doi.org/10.1016/j.bmcl.2009.05.022
https://doi.org/10.1016/j.bmcl.2009.05.022
Autor:
Kim Mai, Tony Muchamuel, Susan Hudak, Christopher G. De Vry, Debra Mutnick, Jie Zhang, Christi Parham, Leslie M. McEvoy, Brian Schryver, Maya Dajee, Timothy Colby, Srinivasa Prasad, Tina Le, László G. Kömüves, Aung Oo, Donald Ruhrmund, Jennifer Alleman-Sposeto, Radha Shyamsundar, Rolf O. Ehrhardt
Publikováno v:
Journal of Investigative Dermatology. 126(8):1792-1803
Atopic dermatitis (AD) is a common chronic skin inflammatory disease. Long-term use of topical corticosteroids in skin inflammation poses risks of systemic and local side effects. The NF-kappaB transcription factor family plays a central role in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23971f9421cc569afdf927ab2a1b1d8
Autor:
Shawn Misialek, Lisa Hooi, Guangyi Wang, Yanzhen He, Antitsa Dimitrova Stoycheva, Debasis Das, Mougang Hu, Jun Sun, Donald Ruhrmund, Leonid Beigelman, Scott D. Seiwert, Karl Kossen, Brad O. Buckman, Jianhua Huang, P. T. Ravi Rajagopalan
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d69fbe4c653de9ca4152f58421e72cc
https://pubmed.ncbi.nlm.nih.gov/19502055
https://pubmed.ncbi.nlm.nih.gov/19502055
Autor:
Shawn Misialek, P. T. Ravi Rajagopalan, Karl Kossen, Guangyi Wang, Xiaomin Wu, Laiguo Zhang, Debasis Das, Lisa Hooi, Donald Ruhrmund, Scott D. Seiwert, Brad O. Buckman, Leonid Beigelman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
3-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0839e538c66f81e14d0adfb051849f1
https://pubmed.ncbi.nlm.nih.gov/19497737
https://pubmed.ncbi.nlm.nih.gov/19497737