Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Donald R. Polaski"'
Autor:
Mariateresa Fulciniti, Zoe Jacobson, Georg E. Winter, Michael A. Erb, Michael A. Lopez, Evon Poon, Donald R. Polaski, Thomas F. Westbrook, Jaime M. Reyes, James E. Bradner, Matthew A. Lawlor, Charles Y. Lin, Rachel A. Hirsch, Rhamy Zeid, Nikhil P. Munshi, Louis Chesler, Behnam Nabet, Kristen L. Karlin, Thomas G. Scott
Publikováno v:
Nature Genetics. 50:515-523
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fa9dc6c212cc89df74f448dcc03322
https://doi.org/10.1038/s41588-018-0044-9
https://doi.org/10.1038/s41588-018-0044-9
Autor:
Josephine L. Klitgaard, Siddha Kasar, Deepti Gadi, Donald R. Polaski, Qiyuan Li, Matthew L. Freedman, Alexander J. Federation, Christopher J. Ott, Stacey M. Fernandes, Amanda Souza, James E. Bradner, Romina E. Lenci, Jennifer R. Brown, Matthew A. Lawlor, Logan Schwartz
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define the core transcriptional regulatory circuits of normal and malignant cells. Gene control through enhancer activity is often dominated by a subset of lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75dbad923dceb29064f184d31c23aa8
https://europepmc.org/articles/PMC6298230/
https://europepmc.org/articles/PMC6298230/
Autor:
James E. Bradner, Donald R. Polaski, Angela Fan, Christopher J. Ott, Alexander J. Federation, Charles Y. Lin
Regulation of gene expression through binding of transcription factors (TFs) to cis-regulatory elements is highly complex in mammalian cells. Genome-wide measurement technologies provide new means to understand this regulation, and models of TF regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4199a8a75cdc9425054218803bb2ecc9
https://doi.org/10.1101/345413
https://doi.org/10.1101/345413
Autor:
Volker Hovestadt, Peter Lichter, Linlin Yin, Sebastian M. Waszak, Victor V. Chizhikov, Maia Segura-Wang, Donald R. Polaski, Marc Zapatka, Parthiv Haldipur, Marcel Kool, Andrey Korshunov, James E. Bradner, Paul A. Northcott, Roland Eils, David T.W. Jones, Laura Sieber, Lukas Chavez, Bensheng Ju, Wenbiao Chen, Barbara C. Worst, Yiai Tong, Pascal Johann, Hans Lehrach, Rhamy Zeid, Vyacheslav Amstislavskiy, Serap Erkek, Thomas Risch, Ivo Buchhalter, Stefan M. Pfister, Marie-Laure Yaspo, Stefan Gröschel, Brent A. Orr, Daisuke Kawauchi, Jan O. Korbel, Hans-Jörg Warnatz, Kathleen J. Millen, Marina Ryzhova, Charles Y. Lin, Alexander J. Federation
Publikováno v:
Nature
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. An unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88de35f0b25c0c3ecc0f6f80faa329b
https://doi.org/10.1038/nature16546
https://doi.org/10.1038/nature16546
Autor:
Marc Zapatka, Stefan M. Pfister, Marcel Kool, David T.W. Jones, Daisuke Kawauchi, Vyacheslav Amstislavskiy, Parthiv Haldipur, Marie-Laure Yaspo, Bensheng Ju, Paul A. Northcott, Brent A. Orr, Wenbiao Chen, Peter Lichter, Barbara C. Worst, Yiai Tong, Marina Ryzhova, Stefan Gröschel, Laura Sieber, Donald R. Polaski, Kathleen J. Millen, Pascal Johann, Volker Hovestadt, Alexander J. Federation, Serap Erkek, Roland Eils, Jan O. Korbel, Hans Lehrach, Charles Y. Lin, Linlin Yang, Rhamy Zeid, Thomas Risch, Ivo Buchhalter, Andrey Korshunov, Hans-Jörg Warnatz, Sebastian M. Waszak, Victor V. Chizhikov, James E. Bradner, Maia Segura-Wang
Publikováno v:
Molecular Cancer Therapeutics. 14:LB-B23
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour. An unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eed4d827a87b1b0dc522baca289af7c
https://doi.org/10.1158/1535-7163.targ-15-lb-b23
https://doi.org/10.1158/1535-7163.targ-15-lb-b23