Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Donald R. McLachlan"'
Autor:
Maire E. Percy, Vivian Jaber, Nathan M. Sharfman, Yuhai Zhao, T.P.A. Kruck, Wenhong Li, Donald R. McLachlan, Walter J. Lukiw, William J. Walsh, Aileen I. Pogue, Zhide Fang, Catherine Bergeron, Peter N. Alexandrov
Publikováno v:
Molecular Neurobiology. 56:1531-1538
With continuing cooperation from 18 domestic and international brain banks over the last 36 years, we have analyzed the aluminum content of the temporal lobe neocortex of 511 high-quality human female brain samples from 16 diverse neurological and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f168667cee2eac2b2644d72c36b6ff
https://doi.org/10.1007/s12035-018-1441-x
https://doi.org/10.1007/s12035-018-1441-x
Autor:
Nathan M. Sharfman, Walter J. Lukiw, Zhide Fang, Maire E. Percy, Catherine Bergeron, Yuhai Zhao, Peter N. Alexandrov, William J. Walsh, Aileen I. Pogue, Wenhong Li, Frank Culicchia, T.P.A. Kruck, Donald R. McLachlan, Vivian Jaber
Publikováno v:
Journal of Alzheimer's disease & Parkinsonism
Aluminum is a ubiquitous neurotoxin highly enriched in our biosphere, and has been implicated in the etiology and pathology of multiple neurological diseases that involve inflammatory neural degeneration, behavioral impairment and cognitive decline.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f044b41496933f7f3f6948360eeca38
http://europepmc.org/articles/PMC6550484
http://europepmc.org/articles/PMC6550484
Publikováno v:
Electrophoresis. 21:2359-2367
Existing methods for the analysis of histone H1 by capillary electrophoresis (CE) employ acidic buffers (pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6b3ecfbd0d3f308d9fe6d945513f94
https://doi.org/10.1002/1522-2683(20000701)21:12<2359::aid-elps2359>3.0.co
https://doi.org/10.1002/1522-2683(20000701)21:12<2359::aid-elps2359>3.0.co
Publikováno v:
Journal of Molecular Neuroscience. 11:67-78
The incorporation of [alpha-32P]-uridine triphosphate into DNA transcription products was examined in short post-mortem interval (PMI) human brain neocortical nuclei (n, 22; PMI, 0.5-24 h) using run-on-gene transcription. Reverse Northern dot-blot hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37929eab35d1518f07f9837e81d4fbbf
https://doi.org/10.1385/jmn:11:1:67
https://doi.org/10.1385/jmn:11:1:67
Publikováno v:
Therapeutic Drug Monitoring. 15:602-607
Drug trials designed to modify the progression of Alzheimer's disease (AD) have required the development of mental state and behavior evaluation instruments that are sensitive to cognitive decline and measure skills useful in everyday living. We desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7876f110103c05bbbd3227d767e83545
https://doi.org/10.1097/00007691-199312000-00027
https://doi.org/10.1097/00007691-199312000-00027
Publikováno v:
Clinical Biochemistry. 26:339-349
One of the principal identifying features of Alzheimer's disease (AD) is the extracellular deposition of fibrous protein aggregates in the form of amyloid plaques. The major component of these deposits is the amyloid beta (A beta) protein that is a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0aab740fc823b06c8d172ad62b8db4
https://doi.org/10.1016/0009-9120(93)90110-r
https://doi.org/10.1016/0009-9120(93)90110-r
Autor:
Donald R. McLachlan, Sharon J. Bauer, Martin J. Somerville, Barbara Chodakowski, Ethylin Wang Jabs, Dorothy A. Miller, Maire E. Percy, Thomas G. Dearie, Anne Lennox, Antonio Baldini
Publikováno v:
American Journal of Medical Genetics. 47:14-19
We have further characterized an unusual 22p+ marker chromosome with a double nucleolus organizer region (dNOR) previously identified in a family with late-onset dementia of the Alzheimer type. G-banding and morphology of the marker's q arm were typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a32c1e989a47c67196fbd4a4ef4e2
https://doi.org/10.1002/ajmg.1320470104
https://doi.org/10.1002/ajmg.1320470104
Publikováno v:
Journal of Neurochemistry. 61:298-305
The serine protease inhibitor α1-antichymotrypsin (ACT) consistently colocalizes with amyloid deposits of Alzheimer's disease (AD) and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. AD amyloid fibrils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13dc30290ab78f5deb5c1d70aff2e14f
https://doi.org/10.1111/j.1471-4159.1993.tb03568.x
https://doi.org/10.1111/j.1471-4159.1993.tb03568.x
Autor:
A.J. Dalton, Ann C. M. Rusk, Martin J. Somerville, Barbara Chodakowski, Joseph M. Berg, Donald R. McLachlan, David F. Andrews, Vjerica D. Markovic, Maire E. Percy
Publikováno v:
American Journal of Medical Genetics. 45:584-588
We previously observed low level mosaicism (2–4% normal cells) in phytohemagglutinin-stimulated peripheral blood lymphocytes (PBL) in 29% of a small group of elderly persons with Down syndrome (DS). An analysis of cytogenetic data on 154 trisomy 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af0be5f7dc079f6f0e3fd04aae1fe5f
https://doi.org/10.1002/ajmg.1320450513
https://doi.org/10.1002/ajmg.1320450513
A predictor for side effects in patients with Alzheimer's disease treated with deferoxamine mesylate
Publikováno v:
Clinical Pharmacology and Therapeutics. 53:30-37
In a previously reported clinical trial, patients with Alzheimer's disease were treated with deferoxamine mesylate, which resulted in a 50% reduction in the average rate of deterioration over 2 years. There were five deaths in the untreated group dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91785da0198513aafce326f252776832
https://doi.org/10.1038/clpt.1993.6
https://doi.org/10.1038/clpt.1993.6