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pro vyhledávání: '"Donald R. Helinski"'
Autor:
Donald R. Helinski
Publikováno v:
EcoSal Plus. 10(1)
In the late 1950s, a number of laboratories took up the study of plasmids once the discovery was made that extrachromosomal antibiotic resistance (R) factors are the responsible agents for the transmissibility of multiple antibiotic resistance among
Autor:
Ralph R. Isberg, Felipe C. Cabello, J. M. Ortiz, Fred Heffron, John J. Mekalanos, Stuart B. Levy, Stanley N. Cohen, Magdalene So, Rino Rappuoli, Kenneth N. Timmis, B. B. Finlay, D. J. Kopecko, J. van Embden, Roy Curtiss, Donald R. Helinski, Marilyn C. Roberts, Gordon Dougan, R. Hull, S. Hull
Publikováno v:
Environmental microbiology. 20(7)
Publikováno v:
Applied Biosafety. 15:32-44
Bacteriophages are bacterial viruses and consist of a single- or double-stranded DNA or RNA protected by a protein capsid. They are able to infect bacteria by injecting their nucleic acids inside t...
Publikováno v:
Plasmid. 56:124-132
Multi-copy plasmids in Escherichia coli are not randomly distributed throughout the cell but are present as clusters of plasmid molecules that are localized at preferred cellular locations. A plasmid RK2 derivative (pZZ15) that can be tagged with a g
Publikováno v:
Journal of Bacteriology. 187:3538-3547
Multicopy plasmids in Escherichia coli are not randomly distributed throughout the cell but exist as defined clusters that are localized at the mid-cell, or at the 1/4 and 3/4 cell length positions. To explore the factors that contribute to plasmid c
Publikováno v:
Alimentary Pharmacology & Therapeutics. 20:623-628
Summary Background : Treatment options for non-alcoholic steatohepatitis (NASH) are limited. Weight loss remains the most recommended therapy. Orlistat is an effective adjunct to dietary weight loss therapy. Aim : To evaluate the efficacy of orlistat
Publikováno v:
Journal of Biological Chemistry. 278:45305-45310
Broad host range plasmid RK2 encodes two versions of its essential replication initiation protein, TrfA, using in-frame translational starts spaced 97 amino acids apart. The smaller protein, TrfA-33, is sufficient for plasmid replication in many bact
Autor:
Donald R. Helinski, Zhenping Zhong, Jane E. Wilkinson, Aresa Toukdarian, Vic Knauf, Terrance P Shea, Craig DeLoughery, Sean M. Sykes, Colleen O’Byrne, Ron Caspi
Publikováno v:
Plasmid. 49:233-252
Two plasmids, 76 and 148 kb in size, isolated from Ruegeria strain PR1b were entirely sequenced. These are the first plasmids to be characterized from this genus of marine bacteria. Sequence analysis revealed a biased distribution of function among t
Publikováno v:
Molecular Microbiology. 44:971-979
Summary Broad-host-range plasmid RK2 encodes a post-segregational killing system, parDE, which contributes to the stable maintenance of this plasmid in Escherichia coli and many distantly related bacteria. The ParE protein is a toxin that inhibits ce