Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Donald R. Gauthier"'
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Total Synthesis of Darobactin A
Autor: Marko Nesic, David B. Ryffel, Jonathan Maturano, Michael Shevlin, Scott R. Pollack, Donald R. Gauthier, Pablo Trigo-Mouriño, Li-Kang Zhang, Danielle M. Schultz, Jamie M. McCabe Dunn, Louis-Charles Campeau, Niki R. Patel, David A. Petrone, David Sarlah
The total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16 steps from ᴅ-Garner’s aldehyde and ʟ-serine.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85995d27bf0e6c17b4961bc72d2ca3c0
https://doi.org/10.26434/chemrxiv-2022-c4mz6
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3
Highly Enantioselective Rhodium-Catalyzed Transfer Hydrogenation of Tetrasubstituted Olefins: Application toward the Synthesis of GPR40 Agonist MK-2305
Autor: Yong-Li Zhong, Yining Ji, Heather Wang, Xiao Wang, Donald R. Gauthier
Publikováno v: Organic letters. 24(17)
A highly efficient enantioselective synthesis for the potent G-protein-coupled receptor 40 agonist MK-2305 was developed. The key tetrasubstituted olefin was prepared via a stereoselective Mukaiyama aldol reaction/elimination sequence. The highly ena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe361798fee685da8a235baeb21352
https://pubmed.ncbi.nlm.nih.gov/35467884
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4
Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification
Autor: Ryan D. Cohen, Nadine Kuhl, Artis Klapars, Lauren Weisel, Susan L. Zultanski, Jamie M. McCabe Dunn, Jon A. Jurica, Anil R. Ekkati, Donald R. Gauthier, Mikhail Reibarkh, Wendy Zhong, Jungchul Kim
Publikováno v: Organic Process Research & Development. 25:597-607
Cyclodextrin (CD) perfunctionalization reactions are challenging to study because they proceed through a number of regioisomeric intermediates, thus warranting creative approaches to understanding ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22a9cef45b0ed5c11d91b36edd5d892
https://doi.org/10.1021/acs.oprd.0c00249
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6
13C NMR-Based Approaches for Solving Challenging Stereochemical Problems
Autor: Andrew Brunskill, R. Thomas Williamson, Donald R. Gauthier, Mikhail Reibarkh, Yizhou Liu, Gary E. Martin, Yong-Li Zhong, Ikenna E. Ndukwe
Publikováno v: Organic Letters. 21:4072-4076
Determining the configuration of proton-deficient molecules is challenging using conventional NMR methods including nuclear Overhauser effect (NOE) and the proton-dependent J-based configuration analysis (JBCA). The problem is exacerbated when only o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::701ec30569184d5864b28c0cc96a92f2
https://doi.org/10.1021/acs.orglett.9b01248
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7
Potassium isopropyl xanthate (PIX): an ultra-efficient palladium scavenger
Autor: Kevin M. Maloney, Guy R. Humphrey, Christopher A. Strulson, Hong Ren, Donald R. Gauthier, Guangtao Li, Rong Xiang
Publikováno v: Green Chemistry. 19:4002-4006
The increasing employment of palladium-catalyzed reactions in the synthesis of active pharmaceutical ingredients (APIs) has created a pressing need for ultra-efficient palladium removal of the resulting metal contaminants. This communication discusse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b54daf5c17dffad8f24af070db7844a
https://doi.org/10.1039/c7gc01765k
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8
Characterization of impurities of HIV NNRTI Doravirine by UHPLC-high resolution MS and tandem MS analysis
Autor: Roy Helmy, Yang Cao, Jinjian Zheng, Li-Kang Zhang, Huaming Sheng, Ross Yang, Donald R. Gauthier
Publikováno v: Journal of Mass Spectrometry. 51:959-968
World Health Organization estimates that 34 million individuals globally are living with Human Immunodeficiency Virus (HIV). Doravirine is a non-nucleoside reverse transcriptase inhibitors (NNRTI) being evaluated by Merck for the treatment of HIV-1 i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ec9138ee1e5b9bae2aafbc2b0643606
https://doi.org/10.1002/jms.3807
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9
Synthesis of [14C]omarigliptin
Autor: Donald R. Gauthier, Sumei Ren, Rosemary Marques, David Hesk, Roy Helmy
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 59:386-390
An efficient synthesis for [(14) C]Omarigliptin (MK-3102) is described. The initial synthesis of a key (14) C-pyrazole moiety did not work due to the lack of stability of (14) C-DMF-DMA reagent. Thus, a new radiolabeled synthon, (14) C-biphenylmethyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7422ea57f5f2186078dfb4aed91aa7be
https://doi.org/10.1002/jlcr.3421
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10
A General, One-Pot Method for the Synthesis of Sulfinic Acids from Methyl Sulfones
Autor: Donald R. Gauthier, Naoki Yoshikawa
Publikováno v: Organic letters. 18(23)
A simple and efficient method for converting methyl sulfones to sulfinic acids is described. The process involves alkylation with a benzylic halide, followed by in situ elimination of the resulting styrene in the presence of excess base to yield a su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6bda765a254e19c51179cb58d9af58
https://pubmed.ncbi.nlm.nih.gov/27934354
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