Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Donald R Shaffer"'
Autor:
Zakaria Grada, Meenakshi Hegde, Tiara Byrd, Donald R Shaffer, Alexia Ghazi, Vita S Brawley, Amanda Corder, Kurt Schönfeld, Joachim Koch, Gianpietro Dotti, Helen E Heslop, Stephen Gottschalk, Winfried S Wels, Matthew L Baker, Nabil Ahmed
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers
Externí odkaz:
https://doaj.org/article/f6109ef91e37425bafdfbf5c6c19c49f
Autor:
Vita S Salsman, Kevin K H Chow, Donald R Shaffer, Huseyin Kadikoy, Xiao-Nan Li, Claudia Gerken, Laszlo Perlaky, Leonid S Metelitsa, Xiuhua Gao, Meena Bhattacharjee, Karen Hirschi, Helen E Heslop, Stephen Gottschalk, Nabil Ahmed
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20267 (2011)
Cancer cells can live and grow if they succeed in creating a favorable niche that often includes elements from the immune system. While T lymphocytes play an important role in the host response to tumor growth, the mechanism of their trafficking to t
Externí odkaz:
https://doaj.org/article/8934db56267140b5836fc475bb10fb93
Autor:
Jessica D. Weaver, Edward C. Stack, Joshua A. Buggé, Changyun Hu, Lara McGrath, Amy Mueller, Masie Wong, Boris Klebanov, Tanzila Rahman, Rosemary Kaufman, Christine Fregeau, Vikki Spaulding, Michelle Priess, Kristen Legendre, Sarah Jaffe, Dhruvkumar Upadhyay, Anirudh Singh, Chang-Ai Xu, Kristin Krukenberg, Yan Zhang, Yassine Ezzyat, Dorothée Saddier Axe, Michelle R. Kuhne, Michael A. Meehl, Donald R. Shaffer, Brian M. Weist, Dmitri Wiederschain, Fabien Depis, Monica Gostissa
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The presence of T regulatory (Treg) cells in the tumor microenvironment is associated with poor prognosis and resistance to therapies aimed at reactivating anti-tumor immune responses. Therefore, depletion of tumor-infiltrating Tregs is a potential a
Externí odkaz:
https://doaj.org/article/9a4049560acc4a71971464efbe2cc5d2
Autor:
Ben Umiker, Yasmin Hashambhoy-Ramsay, Jeff Smith, Tanzila Rahman, Amy Mueller, Rachel Davidson, Christina Meyer, Gayatri Patankar, Mohammad Murshid Alam, Sarah Jaffe, Kristin Krukenberg, Allison Goodman, Vikki Spaulding, Michelle Priess, Abha Dhaneshwar, Masie Wong, Alexa Diiorio, Kristin O'Malley, Lara McGrath, Margaret Willer, Lauren Pepper, Monica Gostissa, Katalin Kis-Toth, Dmitri Wiederschain, Heather Cohen, Donald R. Shaffer
Publikováno v:
Molecular Cancer Therapeutics. 22:471-484
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response as measured by the macrophage polarization score in histoculture explant cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7300803b6c2959ff55929ff818f38977
https://doi.org/10.1158/1535-7163.22551994.v1
https://doi.org/10.1158/1535-7163.22551994.v1
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89f1a6392cc21d33474e1853be7817
https://doi.org/10.1158/1535-7163.c.6534805.v1
https://doi.org/10.1158/1535-7163.c.6534805.v1
Autor:
Donald R. Shaffer, Vikki Spaulding, Edward C. Stack, Kristin Shanea O'malley, Jeffrey W. Smith, Ben Umiker, Margaret Willer, Michelle Priess, Monica Gostissa, Yasmin Hashambhoy-Ramsay
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is an immunoinhibitory protein expressed on the surface of myeloid cells that has been increasingly recognized as a therapeutic target of interest in immuno-oncology (IO). Upon bindi
Autor:
Donald R. Shaffer
Publikováno v:
Journal of American History. 105:1101-1103
Autor:
Donald R. Shaffer, Donald Jackson, Kelly Balko, Liqing Chen, Xiangming Li, Nicole Acuff, Chaomei Shi, Joachim Theilhaber, Yu-an Zhang, Julie-Ann Gavigan, Christen Buetz, Virna Cortez-Retamozo, Michael Lampa, Jill Mooney, Giovanni Abbadessa, Marcos Milla, Caffaro Carolina E, Timothy R. Wagenaar
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A636-A636
BackgroundSAR444245 is a non-alpha IL-2 Synthorin TM molecule designed with a site-specific non-natural amino acid serving as a bioconjugation site for a single PEG. The non-natural amino acid is positioned to enable the PEG bioconjugation to obscure