Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Donald R J Singer"'
Autor:
Andrew Marsh, Katherine Casey-Green, Fay Probert, David Withall, Daniel A Mitchell, Suzanne J Dilly, Sean James, Wade Dimitri, Sweta R Ladwa, Paul C Taylor, Donald R J Singer
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148266 (2016)
Finding pleiomorphic targets for drugs allows new indications or warnings for treatment to be identified. As test of concept, we applied a new chemical genomics approach to uncover additional targets for the widely prescribed lipid-lowering pro-drug
Externí odkaz:
https://doaj.org/article/e9958014ecdc44cc82e9a25c802210d8
Autor:
Athanasios Saratzis, Donald R. J. Singer, Christopher H.E. Imray, Rachel W S Lee, Mahmud Saedon, Charles E Hutchinson
Publikováno v:
Stroke and Vascular Neurology
BackgroundCerebral microemboli may lead to ischaemic neurological complications after carotid endarterectomy (CEA). The association between classical cardiovascular risk factors and acute cerebral microemboli following carotid surgery has not been st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699a58bc03a63461620bb7f403bc2d39
https://doi.org/10.1136/svn-2017-000116
https://doi.org/10.1136/svn-2017-000116
Publikováno v:
Stroke and Vascular Neurology
IntroductionABCD2 risk score and cerebral microemboli detected by transcranial Doppler (TCD) have been separately shown to the predict risk of recurrent acute stroke. We studied whether ABCD2 risk score predicts cerebral microemboli in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91ab3795ad662af78a3203e808238f9
https://doi.org/10.1136/svn-2017-000073
https://doi.org/10.1136/svn-2017-000073
Publikováno v:
Postgraduate Medical Journal, 96(1134), 183-183. BMJ Publishing Group
Health Policy and Technology, 9(1), 5-6. Fellowship of Postgraduate Medicine
Postgraduate Medical Journal
Health Policy and Technology
Health Policy and Technology, 9(1), 5-6. Fellowship of Postgraduate Medicine
Postgraduate Medical Journal
Health Policy and Technology
The Fellowship of Postgraduate Medicine (FPM) is partnering with its journals —Health Policy and Technology and the Postgraduate Medical Journal —to launch international awards for well-informed, clear writing on health matters in social media. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1133d2aede100197da7390516c1342ff
https://pure.eur.nl/en/publications/3a0d5264-7d98-41c0-8b00-4ea9fc7501be
https://pure.eur.nl/en/publications/3a0d5264-7d98-41c0-8b00-4ea9fc7501be
Autor:
Donald R. J. Singer, Zoulikha M. Zaïr
Publikováno v:
Pharmacogenomics. 17:1189-1205
Aim: Chemotherapeutic agents have been shown to increase lung patient survival, however their use may be limited by their serious adverse effects. We aimed to assess int impact of pharmacogenetic variation of influx transporters on inter-individual p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ace3b733a8f492f38d4f3873d3df5d
https://doi.org/10.2217/pgs-2015-0005
https://doi.org/10.2217/pgs-2015-0005
Autor:
Darlington O. Okonko, Amit K J Mandal, Donald R. J. Singer, Paul Highett-Smith, Apurva Bharucha, Constantinos G Missouris, Mohamed Al-Obaidi
Publikováno v:
Postgraduate Medical Journal. 92:450-454
Background The epidemiology of heart disease is changing, with rheumatic heart disease becoming less common but degenerative valve disorders, heart failure and atrial fibrillation (AF) increasing. Objective We sought to determine the prevalence of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e3e25664b4d96c9c01bc9bec95502b
https://doi.org/10.1136/postgradmedj-2014-133001
https://doi.org/10.1136/postgradmedj-2014-133001
Autor:
Zoulikha M. Zaïr, Donald R. J. Singer
Publikováno v:
Pharmacogenomics. 17(9)
Chemotherapeutic drugs are underutilized in lung cancer management due in part to serious adverse drug reactions (ADRs). Aim: With studies revealing an association between interindividual patient ADR variation and efflux transporter variants, we carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb34306a0da3ced1a670d58bca5403d7
https://pubmed.ncbi.nlm.nih.gov/27269636
https://pubmed.ncbi.nlm.nih.gov/27269636
Autor:
Zoulikha M. Zaïr, Donald R. J. Singer
Expected benefits from new technology include more efficient patient selection for clinical trials, more cost-effective treatment pathways for patients and health services and a more profitable accelerated approach for drug developers. Regulatory aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27b093f294f8942744aa323bf97d324
https://doi.org/10.1016/bs.apcsb.2015.11.003
https://doi.org/10.1016/bs.apcsb.2015.11.003
Publikováno v:
Microcirculation. 15:251-267
Reduced capillary density occurs early in cardiovascular diseases. Oxidant stress is implicated in endothelial apoptosis. We investigated the effects of xanthine oxidase (XO) on endothelial survival signaling: protein kinase B/Akt, its cross-talk wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bd177e12a7a9c0f4a1f6f010e45949
https://doi.org/10.1080/10739680701651495
https://doi.org/10.1080/10739680701651495
Publikováno v:
Stroke. 35:853-858
Background and Purpose— Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by ultrastructural abnormalities in small cerebral and systemic vessels. We assessed vasomotor function in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881096f6448818dff326ce497f87cd0f
https://doi.org/10.1161/01.str.0000120730.54282.a0
https://doi.org/10.1161/01.str.0000120730.54282.a0