Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Donald Poirier"'
Autor:
Zahra Kariminezhad, Mahdi Rahimi, Julio Fernandes, René Maltais, Jean-Yves Sancéau, Donald Poirier, Hassan Fahmi, Mohamed Benderdour
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 386 (2024)
In osteoarthritis (OA), oxidative stress plays a crucial role in maintaining and sustaining cartilage degradation. Current OA management requires a combination of pharmaceutical and non-pharmacological strategies, including intraarticular injections
Externí odkaz:
https://doaj.org/article/ab31807c3ab04e18ab6cb47ef9e77fea
Autor:
Donald Poirier
Publikováno v:
Molecules, Vol 28, Iss 8, p 3499 (2023)
Steroid hormones play a crucial role in several aspects of human life, and steroidogenesis is the process by which hormones are produced from cholesterol using several enzymes that work in concert to obtain the appropriate levels of each hormone at t
Externí odkaz:
https://doaj.org/article/27496334aaa849419b503f48660022ca
Publikováno v:
Molecules, Vol 28, Iss 2, p 632 (2023)
Estradiol (E2) plays an important role in the progression of diseases such as breast cancer and endometriosis. Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), the enzyme that catalyzes the last step in the biosynthesis of the estr
Externí odkaz:
https://doaj.org/article/699c84e7e18441a2aac9be8d60c9a621
Publikováno v:
Magnetochemistry, Vol 7, Iss 1, p 3 (2020)
The combination of an androstane-3,17-diol nucleus and a 2β-N-alkylamidopiperazino sidechain is important for the anticancer activity of a new family of steroid derivatives. As the structure-activity relationship studies have so far been limited to
Externí odkaz:
https://doaj.org/article/1ec5a7ea7c204053ba1accac54b67f7f
Publikováno v:
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 10, Iss 2, Pp 68-76 (2015)
Tyramine sulfamate was linked to the trityl chloride resin and this polymeric support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split)
Externí odkaz:
https://doaj.org/article/7c145ec16cba4a18a64a7dddaf92abc5
Publikováno v:
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 9, Iss 2, Pp 67-73 (2014)
3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(p
Externí odkaz:
https://doaj.org/article/e004cb1a8f4c4db182cbacb18fe4ca9c
Autor:
Lucie Carolle Kenmogne, Jenny Roy, René Maltais, Mélanie Rouleau, Bertrand Neveu, Frédéric Pouliot, Donald Poirier
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171871 (2017)
In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is an attractive therapeutic target considering its key role in the formation of androgenic steroids. In this study, we attempted
Externí odkaz:
https://doaj.org/article/2c382a1a4d2f45ac94cf1bc19f657838
Publikováno v:
Molecules, Vol 18, Iss 8, Pp 8812-8836 (2013)
Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H2L1–H2L10) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction
Externí odkaz:
https://doaj.org/article/58bccaa817074962ad45349992a63e44
Publikováno v:
Molecules, Vol 18, Iss 1, Pp 914-933 (2013)
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. A
Externí odkaz:
https://doaj.org/article/bce28ec5438c45d8bf212a7931ac0c9e
Autor:
Sophie Boutin, Donald Poirier
Publikováno v:
Magnetochemistry, Vol 4, Iss 3, p 32 (2018)
17β-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a steroidogenesis enzyme known for its potential role in Alzheimer’s disease. For comparison purposes between steroidal and nonsteroidal 17β-HSD10 inhibitors 1 and 2, respectively, we attem
Externí odkaz:
https://doaj.org/article/0c70c82b83fd48fabdc8284ddc613a25