Zobrazeno 1 - 10
of 384
pro vyhledávání: '"Donald P. McDonnell"'
Autor:
Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Guptta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung-Hee Park, Yajun Wu, Lijin Wang, Boon-Huat Bay, Lei Sun, Vincent Giguere, Pierce K.H. Chow, Sujoy Ghosh, Donald P. McDonnell, Paul M. Yen, Brijesh K. Singh
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101997- (2024)
Objective: Currently, little is known about the mechanism(s) regulating global and specific protein translation during metabolic dysfunction-associated steatohepatitis (MASH; previously known as non-alcoholic steatohepatitis, NASH). Methods: Unbiased
Externí odkaz:
https://doaj.org/article/17f87e3dbde54cfa8579d8857c0fe2d1
Autor:
Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R. Nelson, Sunghee Park, Donald P. McDonnell, Kathryn J. Moore, Lily Jun-shen Huang, Edward A. Fisher, Chieko Mineo, Linzhang Huang, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we show in male mice that hypercho
Externí odkaz:
https://doaj.org/article/acdb55d979ff40c6a879b2daab171d43
Autor:
William H. Tomaszewski, Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, Mustafa Khasraw, David M. Ashley, Peter E. Fecci, Luigi Racioppi, Luis Sanchez-Perez, Michael D. Gunn, John H. Sampson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Responses to immune checkpoint blockade (ICB) in patients with glioblastoma are limited. Here the authors show that Calmodulin-Dependent Kinase Kinase 2 (CaMKK2) is expressed in tumor associated macrophages and neurons and is associated with resistan
Externí odkaz:
https://doaj.org/article/d2bad1bc29a045f7afdb7b2e7787b8de
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
High cholesterol has been associated with increased risk of cancer but the underlying mechanism is not completely understood. Here, the authors show that a cholesterol metabolite induces metabolic reprogramming that generates ferroptosis-resistant ca
Externí odkaz:
https://doaj.org/article/ef682fd9b47c4243a18058a5dedb403b
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Shonagh Russell, Felicia Lim, Pamela N. Peters, Suzanne E. Wardell, Regina Whitaker, Ching-Yi Chang, Rebecca A. Previs, Donald P. McDonnell
Publikováno v:
Cancers, Vol 14, Iss 17, p 4219 (2022)
Despite advances in surgery and targeted therapies, the prognosis for women with high-grade serous ovarian cancer remains poor. Moreover, unlike other cancers, immunotherapy has minimally impacted outcomes in patients with ovarian cancer. Progress in
Externí odkaz:
https://doaj.org/article/f9c9e8282d9a4a9b9b812db1ede61a23
Autor:
Luigi Racioppi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E. Baek, David H. Drewry, William J. Zuercher, Francesca R. Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R. Means, Nelson Chao, Ching-yi Chang, Donald P. McDonnell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages p
Externí odkaz:
https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
Autor:
Laurel A. Coons, Adam B. Burkholder, Sylvia C. Hewitt, Donald P. McDonnell, Kenneth S. Korach
Publikováno v:
iScience, Vol 15, Iss , Pp 552-591 (2019)
Summary: Understanding why a transcription factor (TF) binds to a specific DNA element in the genome and whether that binding event affects transcriptional output remains a great challenge. In this study, we demonstrate that TF binding in the genome
Externí odkaz:
https://doaj.org/article/db4cc1500bcd499a88dba23c1addf024
Autor:
Kimberly J. Cocce, Jeff S. Jasper, Taylor K. Desautels, Logan Everett, Suzanne Wardell, Thomas Westerling, Robert Baldi, Tricia M. Wright, Kendall Tavares, Alex Yllanes, Yeeun Bae, Jeremy T. Blitzer, Craig Logsdon, Daniel P. Rakiec, David A. Ruddy, Tiancong Jiang, Gloria Broadwater, Terry Hyslop, Allison Hall, Muriel Laine, Linda Phung, Geoffrey L. Greene, Lesley-Ann Martin, Sunil Pancholi, Mitch Dowsett, Simone Detre, Jeffrey R. Marks, Gregory E. Crawford, Myles Brown, John D. Norris, Ching-yi Chang, Donald P. McDonnell
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 889-903.e10 (2019)
Summary: Notwithstanding the positive clinical impact of endocrine therapies in estrogen receptor-alpha (ERα)-positive breast cancer, de novo and acquired resistance limits the therapeutic lifespan of existing drugs. Taking the position that resista
Externí odkaz:
https://doaj.org/article/c0b467352d604bac96892990f6f1dd91
Autor:
Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell, Kris C. Wood
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Mitochondrial dynamics regulate critical processes. Here the authors show that genes regulating mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated with changes in drug sensitivity including inc
Externí odkaz:
https://doaj.org/article/de9748c806cf4ead9e12f2fd548f0dad