Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donald P. Lombardi"'
Autor:
Philip Sjostedt, Charles Thompson, Liza Squires, Irmgard Eichler, Donald P. Lombardi, Mark A. Turner
Publikováno v:
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
Background:Obtaining assent from children participating in clinical trials acknowledges autonomy and developmental ability tocontribute to the consent process. This critical step in pediatric drug development remains poorly understood, with significa
Publikováno v:
Therapeutic Innovation & Regulatory Science. 47:542-549
An industry-based survey was conducted by the Global Alliance for Pediatric Therapeutics in February 2013 to determine and evaluate the current industry practices in the assessment of palatability and swallowability during the development of pediatri
Publikováno v:
Therapeutic Innovation & Regulatory Science. 47:533-541
Background: Palatability and swallowability of oral dosage forms are important considerations in the development of medications for pediatric populations. As a result of recent legislation, the number of pharmaceutical products being developed with f
Autor:
Denver Hendricks, Joseph Geradts, Robert Maynard, Michael J. Birrer, J. Carl Barrett, Kwun M. Fong, Donald P. Lombardi, Susan L. Abbondanzo
Publikováno v:
The American Journal of Pathology. 154:1665-1671
The metastasis suppressor gene KAI1 was identified by its ability to inhibit the formation of pulmonary metastases in experimental models for prostatic carcinoma. Down-regulation of this gene may be correlated with the invasive phenotype in melanomas
Publikováno v:
Journal of Clinical Investigation. 96:2744-2747
We have studied the effect of chemotherapy on the level of a particular kind of genetic instability in patients with Hodgkin's disease. The particular type of genetic instability assayed is exemplified by trans-rearrangements between two (rather than
Publikováno v:
Blood. 79:1327-1333
The SCL gene, initially discovered at the site of a translocation breakpoint associated with the development of a stem cell leukemia, encodes a protein that contains the highly conserved basic helix-loop- helix (bHLH) motif found in a large array of
Autor:
Maureen E. Trudeau, Jennifer L. Harris, Dennis L. Citrin, Tal Zaks, Kimberley Blackwell, Neil L. Spector, Slim Ben Ahmed, Ron E. Westlund, Hamouda Boussen, Patricia LoRusso, Donald P. Lombardi, V. M. Salazar, Stephen R. D. Johnston, Michelle DeSilvio, Bella Kaufman
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(7)
Purpose Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. Lapatinib, an oral reversible inhibitor of epidermal growth factor receptor (EGFR) and human EGFR 2 (HER-2), demonstrated clinical activity in four of five
Publikováno v:
Cancer cell. 6(2)
Women with ErbB2-positive breast cancer have a poor prognosis, and frequently, chemotherapy treatment is ineffective. The ErbB2-targeted antibody trastuzumab improves survival when given with chemotherapy to patients with ErbB2-overexpressing metasta
Autor:
William H. Frawley, Raheela Ashfaq, Charles F. Timmons, Donald P. Lombardi, Patrick J. Leavey
Publikováno v:
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 9(3)
Recent evidence implicates cell surface proteins of the tetraspanin superfamily in the process of metastasis whereas the downregulation of KAI-1, a member of the tetraspanin family, is associated with an aggressive clinical phenotype in several types
Publikováno v:
The Journal of urology. 167(1)
Chemotherapy is often used as a primary therapy for metastatic cancer because it kills cells en masse. However, high doses of chemotherapeutic drugs can cause toxicity in nontarget organs. Gene therapy may provide a better alternative to chemotherapy