Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial

Autor: Mary M. McDermott, Christopher R. Martens, Kathryn J. Domanchuk, Dongxue Zhang, Clara B. Peek, Michael H. Criqui, Luigi Ferrucci, Philip Greenland, Jack M. Guralnik, Karen J. Ho, Melina R. Kibbe, Kate Kosmac, Donald Lloyd-Jones, Charlotte A. Peterson, Robert Sufit, Lu Tian, Stephanie Wohlgemuth, Lihui Zhao, Pei Zhu, Christiaan Leeuwenburgh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respirat

Externí odkaz: https://doaj.org/article/2c373f254eb346318d878694e2b1a44e

Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system

Autor: Yuan Luo, Chengsheng Mao, Lazaro N. Sanchez‐Pinto, Faraz S. Ahmad, Andrew Naidech, Luke Rasmussen, Jennifer A. Pacheco, Daniel Schneider, Leena B. Mithal, Scott Dresden, Kristi Holmes, Matthew Carson, Sanjiv J. Shah, Seema Khan, Susan Clare, Richard G. Wunderink, Huiping Liu, Theresa Walunas, Lee Cooper, Feng Yue, Firas Wehbe, Deyu Fang, David M. Liebovitz, Michael Markl, Kelly N. Michelson, Susanna A. McColley, Marianne Green, Justin Starren, Ronald T. Ackermann, Richard T. D'Aquila, James Adams, Donald Lloyd‐Jones, Rex L. Chisholm, Abel Kho

Publikováno v: Learning Health Systems, Vol 8, Iss 3, Pp n/a-n/a (2024)

Abstract Introduction The rapid development of artificial intelligence (AI) in healthcare has exposed the unmet need for growing a multidisciplinary workforce that can collaborate effectively in the learning health systems. Maximizing the synergy amo

Externí odkaz: https://doaj.org/article/fccb3f4f664548e18079946ab3e1a555

Area deprivation and premature cardiovascular mortality: a nationwide population-based study in South Korea

Autor: Hyeon Chang Kim, Hokyou Lee, Eunji Kim, Donald Lloyd-Jones, Young Gyu Ko, Byoung Gwon Kim

Publikováno v: BMJ Public Health, Vol 2, Iss 1 (2024)

Background Regional disparities in cardiovascular disease (CVD) burden exist. The effect of area deprivation, one of the possible explanations, still needs to be fully understood. This population-based study investigated the association between Area

Externí odkaz: https://doaj.org/article/4c9be6e03de94511abd2d96ac648ad0d

Advancing the care of individuals with cancer through innovation & technology: Proceedings from the cardiology oncology innovation summit 2020 and 2021

Autor: Sherry-Ann Brown, Craig Beavers, Brenton Bauer, Richard K. Cheng, Generika Berman, Catherine H. Marshall, Avirup Guha, Prantesh Jain, Austin Steward, Jeanne M. DeCara, Iredia M. Olaye, Kathryn Hansen, Jim Logan, Carmen Bergom, Carri Glide-Hurst, Irving Loh, John Alan Gambril, James MacLeod, Ragasnehith Maddula, Peter J. McGranaghan, Akshee Batra, Courtney Campbell, Abdulaziz Hamid, Fatma Gunturkun, Robert Davis, John Jefferies, Michael Fradley, Katherine Albert, Anne Blaes, Indrajit Choudhuri, Arjun K. Ghosh, Thomas D. Ryan, Ogochukwu Ezeoke, Douglas J. Leedy, Wadsworth Williams, Sebastian Roman, Lorenz Lehmann, Abdullah Sarkar, Diego Sadler, Elizabeth Polter, Kathryn J. Ruddy, Neha Bansal, Eric Yang, Brijesh Patel, David Cho, Alison Bailey, Daniel Addison, Vijay Rao, Joshua E. Levenson, Dipti Itchhaporia, Karol Watson, Martha Gulati, Kim Williams, Donald Lloyd-Jones, Erin Michos, Julie Gralow, Hugo Martinez

Publikováno v: American Heart Journal Plus, Vol 38, Iss , Pp 100354- (2024)

As cancer therapies increase in effectiveness and patients' life expectancies improve, balancing oncologic efficacy while reducing acute and long-term cardiovascular toxicities has become of paramount importance. To address this pressing need, the Ca

Externí odkaz: https://doaj.org/article/8043007b5ee04ac89d1b9f4d2fd3cdc7

Rare coding variants in RCN3 are associated with blood pressure

Autor: Karen Y. He, Tanika N. Kelly, Heming Wang, Jingjing Liang, Luke Zhu, Brian E. Cade, Themistocles L. Assimes, Lewis C. Becker, Amber L. Beitelshees, Lawrence F. Bielak, Adam P. Bress, Jennifer A. Brody, Yen-Pei Christy Chang, Yi-Cheng Chang, Paul S. de Vries, Ravindranath Duggirala, Ervin R. Fox, Nora Franceschini, Anna L. Furniss, Yan Gao, Xiuqing Guo, Jeffrey Haessler, Yi-Jen Hung, Shih-Jen Hwang, Marguerite Ryan Irvin, Rita R. Kalyani, Ching-Ti Liu, Chunyu Liu, Lisa Warsinger Martin, May E. Montasser, Paul M. Muntner, Stanford Mwasongwe, Take Naseri, Walter Palmas, Muagututi’a Sefuiva Reupena, Kenneth M. Rice, Wayne H.-H. Sheu, Daichi Shimbo, Jennifer A. Smith, Beverly M. Snively, Lisa R. Yanek, Wei Zhao, John Blangero, Eric Boerwinkle, Yii-Der Ida Chen, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Myriam Fornage, Jiang He, Lifang Hou, Robert C. Kaplan, Sharon L. R. Kardia, Eimear E. Kenny, Charles Kooperberg, Donald Lloyd-Jones, Ruth J. F. Loos, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Kari E. North, Patricia A. Peyser, Bruce M. Psaty, Laura M. Raffield, D. C. Rao, Susan Redline, Alex P. Reiner, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell Tracy, Ramachandran S. Vasan, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Alanna C. Morrison, Daniel Levy, Aravinda Chakravarti, Donna K. Arnett, Xiaofeng Zhu

Publikováno v: BMC Genomics, Vol 23, Iss 1, Pp 1-18 (2022)

Abstract Background While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans

Externí odkaz: https://doaj.org/article/ef3227d670ad41388d430a8ee8f9216c