Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Donald P. Fraser"'
Autor:
Giorgio Fedele, Graham Hill, Amelia Sweetford, Suki Lee, Bobby Yau, Domenico R. Caputo, Denise Grovewood, Rowda Dahir, Paula Esquivias Ruiz-Dana, Anika Wisniewska, Anna Di Biase, Miles Gibson, Benita Percival, Stefan Grujic, Donald P. Fraser
Publikováno v:
SLAS Technology, Vol 29, Iss 5, Pp 100195- (2024)
Polymerase chain reaction (PCR)-based assays were widely deployed during the SARS-CoV-2 pandemic for population-scale testing. High-throughput molecular diagnostic laboratories required a high degree of process automation to cope with huge testing de
Externí odkaz:
https://doaj.org/article/0d2790d5b7fa42f3b2cbe1cd592597a5
Autor:
Lucy J. Newbury, Kate Simpson, Usman Khalid, Imogen John, Lluís Bailach de Rivera, Yueh-An Lu, Melisa Lopez-Anton, William J. Watkins, Robert H. Jenkins, Donald J. Fraser, Timothy Bowen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Acute kidney injury (AKI) is a global clinical problem characterised by a sudden decline in renal function and mortality as high as 60%. Current AKI biomarkers have limited ability to classify disease progression and identify underlying path
Externí odkaz:
https://doaj.org/article/bbd1249645f6449c9a3ff632580f6632
Autor:
Usman Khalid, Robert H. Jenkins, Robert Andrews, Gilda Pino-Chavez, Benjamin C. Cossins, Rafael Chavez, Timothy Bowen, Donald J. Fraser
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Ischemic preconditioning (IPC) is effective in limiting subsequent ischemic acute kidney injury in experimental models. MicroRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. We ev
Externí odkaz:
https://doaj.org/article/f300b59f825445b7aca92d3fdb870348
Autor:
Amy C. Brook, Robert H. Jenkins, Aled Clayton, Ann Kift-Morgan, Anne-Catherine Raby, Alex P. Shephard, Barbara Mariotti, Simone M. Cuff, Flavia Bazzoni, Timothy Bowen, Donald J. Fraser, Matthias Eberl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Infection remains a major cause of morbidity, mortality and technique failure in patients with end stage kidney failure who receive peritoneal dialysis (PD). Recent research suggests that the early inflammatory response at the site of infect
Externí odkaz:
https://doaj.org/article/aa42ce379e3041e1bb9a6b1736dfbe8e
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Clay is thought to have played a part in the origin of life. Here, the authors show that layered double hydroxides, a type of clay little studied despite its presumed prevalence on the early Earth, can facilitate the formation of small proteins.
Externí odkaz:
https://doaj.org/article/08518761b0e5431ba30ef28dd41bc571
Autor:
Vanessa Marchant, Antonio Tejera-Muñoz, Laura Marquez-Expósito, Sandra Rayego-Mateos, Raul R. Rodrigues-Diez, Lucia Tejedor, Laura Santos-Sanchez, Jesús Egido, Alberto Ortiz, Jose M. Valdivielso, Donald J. Fraser, Manuel López-Cabrera, Rafael Selgas, Marta Ruiz-Ortega
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1361 (2020)
Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy option for ESRD patients
Externí odkaz:
https://doaj.org/article/c203dffe88374e5ca1c163b53c65b8ba
Publikováno v:
Non-Coding RNA, Vol 4, Iss 4, p 30 (2018)
The kidneys play key roles in the maintenance of homeostasis, including fluid balance, blood filtration, erythropoiesis and hormone production. Disease-driven perturbation of renal function therefore has profound pathological effects, and chronic kid
Externí odkaz:
https://doaj.org/article/765d8781513f419c89831a2e3be085c7
Autor:
Paige E. Panter, Antony N. Dodd, Keara A. Franklin, Donald P. Fraser, Ashutosh Sharma, Bhavana Sharma
Publikováno v:
Fraser, D P, Panter, P E, Sharma, A, Sharma, B, Dodd, A N & Franklin, K A 2021, ' Phytochrome A elevates plant circadian clock components to suppress shade avoidance in deep canopy shade ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 27, e2108176118 . https://doi.org/10.1073/pnas.2108176118
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Shade-avoiding plants can detect the presence of neighboring vegetation and evoke escape responses before canopy cover limits photosynthesis. Rapid stem elongation facilitates light foraging and enables plants to overtop competitors. A major regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035c952f8b6f63a14990bcca5521c831
https://doi.org/10.1073/pnas.2108176118
https://doi.org/10.1073/pnas.2108176118
Autor:
Keara A. Franklin, Antony N. Dodd, Kalliopi-Ioanna Kostaki, Verity C. Bonnell, Peng Sun, Deirdre H. McLachlan, Donald P. Fraser, Alistair M. Hetherington, Aude Coupel-Ledru, Mathilda Gustavsson, Fiona J. McLaughlin
Publikováno v:
Plant Physiology
High temperature promotes guard cell expansion, which opens stomatal pores to facilitate leaf cooling. How the high-temperature signal is perceived and transmitted to regulate stomatal aperture is, however, unknown. Here, we used a reverse-genetics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b7547a75cc0b87e85a2ada0149e31a
https://zenodo.org/record/4457239
https://zenodo.org/record/4457239
Autor:
John Martin, Robert H Jenkins, Rasha Bennagi, Aleksandra Krupa, Aled O Phillips, Timothy Bowen, Donald J Fraser
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25044 (2011)
Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis. TGF-β1 is post-transcriptionally
Externí odkaz:
https://doaj.org/article/1cfc9e5850c84e609d330e07ba43a790