Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Donald P. Cameron"'
Autor:
Donald P. Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga, Grant A. McArthur, Nadine Hein, Ross Hannan, Konstantin I. Panov
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1514 (2024)
While genotoxic chemotherapeutic agents are among the most effective tools to combat cancer, they are often associated with severe adverse effects caused by indiscriminate DNA damage in non-tumor tissue as well as increased risk of secondary carcinog
Externí odkaz:
https://doaj.org/article/0031e3f1325e48ca8848fce2543db31b
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101581- (2022)
Summary: TOP1 CAD-seq enables mapping of TOP1 sites of covalent engagement with DNA. The procedure depends upon enrichment of DNA-covalent adducts using chaotropic salts and immunoprecipitation with an antibody specific for TOP1. Here, we describe a
Externí odkaz:
https://doaj.org/article/41fd4ee2fb254065ab8c09f85533b74f
Autor:
Jinbae Son, Katherine M. Hannan, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Richard B. Pearson, Ross D. Hannan, Elaine Sanij
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have demonstrated that inhibition of rDNA transcription by th
Externí odkaz:
https://doaj.org/article/d1352252bad3409b96196916aa6676cf
Autor:
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P Cameron, Laura Baranello, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009954 (2021)
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by which the viruses hijack the cellular enzymes are largely unknown. We found that topoisomerase-II (TOP2) is a substrate of the Epstein-Barr virus (EBV) ubiquitin
Externí odkaz:
https://doaj.org/article/19987ba58b534c27bc4d47f405f3f9d1
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009763 (2021)
The structural maintenance of chromosome (SMC) complex cohesin mediates sister chromatid cohesion established during replication, and damage-induced cohesion formed in response to DSBs post-replication. The translesion synthesis polymerase Polη is r
Externí odkaz:
https://doaj.org/article/a3d88a91aed548d38e29c534e4bbc1f5
Autor:
Lars-Gunnar Larsson, John Inge Johnsen, Sven Nelander, Laura Baranello, Sören Lehmann, Per Hydbring, Loay Mahmoud, Sheryl Y. Lim, Linnéa Schmidt, Vasiliki Verschut, Thale Kristin Olsen, Cecilia Dyberg, Donald P. Cameron, Cecilia Krona, Marcela Franco, Mohammad Alzrigat, Malin Wickström, Fan Zhang, Wesam Bazzar, Karin Fawkner, Qinzi Yan, Alina Castell
Deregulated expression of MYC family oncogenes occurs frequently in human cancer and is often associated with aggressive disease and poor prognosis. While MYC is a highly warranted target, it has been considered “undruggable,” and no specific ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a431701aaf0ab30ac5e1fe7ec1b18f
https://doi.org/10.1158/2767-9764.c.6550598
https://doi.org/10.1158/2767-9764.c.6550598
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
All Supplementary Methods and associated references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019c8dd00fb9804dbcab5c9c85324ed7
https://doi.org/10.1158/2159-8290.22537003
https://doi.org/10.1158/2159-8290.22537003
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer. We evaluated CX-5461, the first-in-class selective rDNA transcription inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918b37c279b207d3fe24ae1fef2b4322
https://doi.org/10.1158/2159-8290.c.6548299.v1
https://doi.org/10.1158/2159-8290.c.6548299.v1
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
Exposure-response relationship between CX-5461 levels and rDNA transcription rate in normal PBMCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cceb0aafa9c3ab75e00b6fe72c5a29
https://doi.org/10.1158/2159-8290.22537006.v1
https://doi.org/10.1158/2159-8290.22537006.v1
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
All Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee167dcf7bf74ae65a5fd3cc711e6d9e
https://doi.org/10.1158/2159-8290.22537000
https://doi.org/10.1158/2159-8290.22537000