Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Donald O'Keefe"'
Autor:
Naveen Seth, Donald O'Keefe
Publikováno v:
2012 ASEE Annual Conference & Exposition Proceedings.
Autor:
Eugene Zhukovsky, Araz Eivazi, Alice Kim, Lisa Cherry, Omid Vafa, Peter Cheung, Jost Vielmetter, Paul Michael Steed, Sandhya Kashi, Arthur J. Chirino, Jonathan Zalevsky, John R. Desjarlais, Linus Hyun, Marian Hwang, Christina Abbott, Rend S. Hubert, Esther Kim, David E. Szymkowski, Sarah X. Gao, C. O'Brien, James Kung, Hyo H. Chung, Malú G. Tansey, Donald O'keefe, Sean Yoder, Stephen K. Doberstein, David F. Carmichael, Karen Singer, Anton Filikov, T. Umesh S. Muchhal, Duc-Hanh T. Nguyen, Cheryl Chan, Sabrina P. Martinez, Bassil I. Dahiyat
Publikováno v:
Science (New York, N.Y.). 301(5641)
Tumor necrosis factor (TNF) is a key regulator of inflammatory responses and has been implicated in many pathological conditions. We used structure-based design to engineer variant TNF proteins that rapidly form heterotrimers with native TNF to give