Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Donald N, Cook"'
Autor:
Wenling Li, Hideki Nakano, Wei Fan, Yuanyuan Li, Payel Sil, Keiko Nakano, Fei Zhao, Peer W. Karmaus, Sara A. Grimm, Min Shi, Xin Xu, Ryushin Mizuta, Daisuke Kitamura, Yisong Wan, Michael B. Fessler, Donald N. Cook, Igor Shats, Xiaoling Li, Leping Li
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to development of autoimmune diseases in both humans and mice. However, despite the wel
Externí odkaz:
https://doaj.org/article/eba649c4683647208269358c9f30e162
Autor:
Eunice Y. Lee, Wonson Choi, Adam B. Burkholder, Lalith Perera, Jasmine A. Mack, Frederick W. Miller, Michael B. Fessler, Donald N. Cook, Peer W. F. Karmaus, Hideki Nakano, Stavros Garantziotis, Jennifer H. Madenspacher, John S. House, Farida S. Akhtari, Charles S. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture associated w
Externí odkaz:
https://doaj.org/article/b4c25f7994204ed68ceec9b548045815
Autor:
Gentaro Izumi, Hideki Nakano, Keiko Nakano, Gregory S. Whitehead, Sara A. Grimm, Michael B. Fessler, Peer W. Karmaus, Donald N. Cook
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dendritic cells in the lung may be specialised to mediate specific types of immune function. Here the authors show that subpopulations of mouse CD11b+ lung DC at different stages of maturation and phenotype can promote Th17 or Th2 CD4+ T cell differe
Externí odkaz:
https://doaj.org/article/2d7e7a34ad9741c7b9cd97853b90ab3b
Autor:
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
The intensity and longevity of inflammatory responses to inhaled allergens is determined largely by the balance between effector and regulatory immune responses, but the mechanisms that determine the relative magnitudes of these opposing forces remai
Externí odkaz:
https://doaj.org/article/68c891eaece8469ca1404ec09b7ac379
Autor:
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance, which can ultimately lead to the development of T2D. F
Externí odkaz:
https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd
Autor:
Hsin-I. Huang, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, Jamie R. Privratsky, Junyi J. Zhang, Estefany Y. Reyes, Donghai Wang, Gregory A. Taylor, Michael D. Gunn, Dennis C. Ko, Donald N. Cook, Vidyalakshmi Chandramohan, Steven D. Crowley, Gianna Elena Hammer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intestinal immunity is coordinated by specialized mononuclear phagocyte populations, constituted by a diversity of cell subsets. Although the cell subsets constituting the mononuclear phagocyte network are thought to be similar in both small and larg
Externí odkaz:
https://doaj.org/article/ec895c03dad444b39ecd52aa071d83d9
Autor:
Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
https://pubmed.ncbi.nlm.nih.gov/35113556
Autor:
Hideki, Nakano, Donald N, Cook
Publikováno v:
American journal of respiratory cell and molecular biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35a0a5acacd5cf00e55b26465f34f982
https://pubmed.ncbi.nlm.nih.gov/36264767
https://pubmed.ncbi.nlm.nih.gov/36264767
Autor:
Brita Kilburg-Basnyat, Debra A. Tokarz, Sanjay Varikuti, Jennifer H. Madenspacher, Robert M. Tighe, Myles X Hodge, Michael B. Fessler, Sky W Reece, Kymberly M. Gowdy, Seddon Y. Thomas, Katelyn Dunigan-Russell, Donald N. Cook, Bin Luo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive T-helper cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e7f28b0bbf7b93cec00d20a5d5c2e9
https://doi.org/10.1165/rcmb.2020-0007oc
https://doi.org/10.1165/rcmb.2020-0007oc
Autor:
Hideki Nakano, Donald N. Cook
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:127-128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7de92c4e964cc885e47bc4a0ba2d197
https://doi.org/10.1165/rcmb.2022-0405ed
https://doi.org/10.1165/rcmb.2022-0405ed