Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Donald Massaro"'
Publikováno v:
Journal of Applied Physiology. 113:385-392
Most aspects of human physiology and behavior exhibit 24-h rhythms driven by a master circadian clock in the brain, which synchronizes peripheral clocks. Lung function and ventilation are subject to circadian regulation and exhibit circadian oscillat
Autor:
Gloria DeCarlo Massaro, Donald Massaro
Publikováno v:
Pediatric Research. 70:458-461
Pulmonary developmental alveologenesis occurs, in substantial part, by subdivision (septation) of the gas-exchange saccules of the morphologically immature lung. It determines the starting point of age- and disease-related alveolar loss. Because alve
Autor:
Donald Massaro, Gloria DeCarlo Massaro
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L991-L997
Diminished lung function, indicated by a low forced expiratory volume in one second (FEV1), and short physical stature, predict early mortality from all causes, including cardiovascular, among smokers and never smokers. The basis for these associatio
Autor:
Emma Alexander, Kristin Reiland, Linda Biadasz Clerch, Eric P. Hoffman, Gloria DeCarlo Massaro, Donald Massaro
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L1313-L1326
Alveolar regenerative gene expression is unidentified partly because its onset, after a regenerative stimulus, is unknown. Toward addressing this void, we used a mouse model in which calorie restriction produces alveolar loss, and ad libitum access t
Autor:
Gloria DeCarlo Massaro, Donald Massaro
Publikováno v:
Proceedings of the American Thoracic Society. 3:709-712
In humans, age results in loss of pulmonary alveoli; menopause accelerates loss of diffusing capacity, an index of alveolar surface area; and disease (e.g., chronic obstructive pulmonary disease) results in loss of alveoli. Thus, an important goal fo
Autor:
Donald Massaro, Gloria DeCarlo Massaro
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L866-L870
Female rats and mice have smaller and, per body mass (BM), more alveoli and alveolar surface area (Sa) than males of their respective species. This sexual dimorphism becomes apparent about the time of sexual maturity. It is prevented in rats (not tes
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L1066-L1070
A technically easy, noninvasive means of delivering molecules to alveoli, which act selectively or specifically in the lung, would be experimentally and therapeutically useful. As proof of principle, we took advantage of the spreading ability of pulm
Autor:
Eric P. Hoffman, Linda Biadasz Clerch, Alexander S. Baras, Gloria DeCarlo Massaro, Donald Massaro
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L411-L419
Treatment of newborn mice with dexamethasone (Dex) inhibits the subdivision of lung saccules to form alveoli; treatment with all- trans retinoic acid (RA) prevents this inhibition of septation. To better understand the early molecular signals respons
Autor:
Gloria DeCarlo Massaro, Donald Massaro
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 28:271-274
Autor:
A. Hamid Boulares, Zaki A. Sherif, Donald Massaro, Mark E. Smulson, Anna J. Zoltoski, Puneet S Jolly
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 28:322-329
Airway inflammation is a central feature of asthma and chronic obstructive pulmonary disease. Reactive oxygen species (ROS) contribute to inflammation by damaging DNA, which, in turn, results in the activation of poly(ADP-ribose) polymerase-1 (PARP-1