Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Donald M. Sells"'
Autor:
Donald M. Sells, Abraham Nyska, Katsuhiko Yoshizawa, Amy E. Brix, Micheal P. Jokinen, Michael E. Wyde, Nigel J. Walker, Grace E. Kissling
Publikováno v:
Toxicologic Pathology. 38:1037-1050
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally-similar dioxin-like compounds affect thyroid function and morphology and thyroid hormone metabolism in animals and humans. The National Toxicology Program conducted eight 2-year gavage studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe9869d9a3dd4810f0eb0d6b7b6d8ad
https://doi.org/10.1177/0192623310382560
https://doi.org/10.1177/0192623310382560
Autor:
Abraham Nyska, Grace E. Kissling, Micheal P. Jokinen, Katsuhiko Yoshizawa, Denis P. Orzech, Donald M. Sells, Nigel J. Walker, Michael E. Wyde, Amy E. Brix
Publikováno v:
Toxicologic Pathology. 37:921-937
Results from previously published animal studies suggest that prenatal and postnatal exposure to dioxin and dioxin-like compounds (DLCs) may profoundly affect the reproductive system of both sexes via endocrine disruption. In the present work, we eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43076e6ce8d847ccd8e1248f7e2cb8d7
https://doi.org/10.1177/0192623309351721
https://doi.org/10.1177/0192623309351721
Autor:
Joseph K. Haseman, Donald M. Sells, Abraham Nyska, Micheal Easterling, Ming Yin, Nigel J. Walker, Christopher J. Portier, James R. Hailey, Michael E. Wyde, Michael P. Jokinen, Amy E. Brix, Patrick W. Crockett, John R. Bucher
Publikováno v:
Environmental Health Perspectives
Use of the dioxin toxic equivalency factor (TEF) approach in human risk assessments assumes that the combined effects of dioxin-like compounds in a mixture can be predicted based on a potency-adjusted dose-additive combination of constituents of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753f6e2747f2b2896665603a0b3b5abc
https://doi.org/10.1289/ehp.7351
https://doi.org/10.1289/ehp.7351
Autor:
Abraham Nyska, Donald M. Sells, Micheal P. Jokinen, Denise Orzech, Nigel J. Walker, Tiwanda Marsh, Michael E. Wyde, Amy E. Brix, Katsuhiko Yoshizawa, Joseph K. Haseman
Publikováno v:
Toxicological Sciences. 83:64-77
We evaluated gingival toxicities induced by chronic exposure of female Harlan Sprague-Dawley rats to dioxin and dioxin-like compounds (DLCs) and compared them to similarly induced oral lesions reported in the literature. This investigation represents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f93b3188628092270bddd3f75536e6d
https://doi.org/10.1093/toxsci/kfi016
https://doi.org/10.1093/toxsci/kfi016
Publikováno v:
Toxicologic Pathology. 32:333-337
To test the dioxin toxic equivalency factor methodology, the National Toxicology Program conducted a series of 2-year rat bioassays of dioxin-like compounds. Following gavage exposure of female Harlan Sprague—Dawley rats to 2,3',4,4',5-pentachlorob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8929309090964968f7e45dd3a50b7818
https://doi.org/10.1080/01926230490431817
https://doi.org/10.1080/01926230490431817
Autor:
Abraham Nyska, Joseph K. Haseman, Nigel J. Walker, Amy E. Brix, Donald M. Sells, Micheal P. Jokinen
Publikováno v:
Cardiovascular Toxicology
The effects of chronic exposure to dioxin (2,3,7,8,-tetrachlorodibenzo-p-dioxin [TCDD]) and a dioxin-like compound (3,3′,4,4′,5-pentachlorobiphenyl [PCB126]) on the cardiovascular system were evaluated in female Harlan Sprague-Dawley rats as part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b647a11d71d3585b052f024cf19454
https://doi.org/10.1385/ct:3:4:299
https://doi.org/10.1385/ct:3:4:299
Publikováno v:
Toxicologic Pathology. 23:518-526
Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0.6%) CrI:CD®Br strain Sprague-Dawley rats employed in two 2-yr oncogenicity studies (1,400) and as controls in a 1-yr toxicity study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accc3b50c0aef25c4eea37e72f5ed82d
https://doi.org/10.1177/019262339502300409
https://doi.org/10.1177/019262339502300409
Publikováno v:
Toxicologic Pathology. 20:327-340
A total of 93 tumors of the epidermis, its appendages, and dermis were observed in 1,433 (717 males, 716 females) rats employed in oncogenicity studies over a 2-yr period. Mammary gland neoplasms will be reported separately. Fifty-seven (61.3%) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ef4df2c2653f389a0385eacda43ab4
https://doi.org/10.1177/019262339202000303
https://doi.org/10.1177/019262339202000303
Publikováno v:
Toxicologic Pathology. 20:253-259
Spontaneous primary epithelial neoplasms of the intestinal tract occurred in 6/682 (0.9%) male and 1/694 (0.1%) female Sprague-Dawley rats. Six of 7 neoplasms were adenocarcinomas, and 1 of 7 was an adenoma. Metastasis to the liver or lung occurred i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553a7d5e6217cdc8374dca516a162e86
https://doi.org/10.1177/019262339202000212
https://doi.org/10.1177/019262339202000212
Publikováno v:
Toxicologic Pathology. 20:125-130
Primary neoplasms of the kidneys occurred in 11/682 male (1.6%) and 2/694 female (0.3%) Crl:CD®Br strain Sprague-Dawley rats. Eight of 13 neoplasms were of mesenchymal origin and 5 of 13 were epithelial. Five neoplasms were lipoma (3) or liposarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118956863a9b4c0b472ac838623f9c47
https://doi.org/10.1177/019262339202000117
https://doi.org/10.1177/019262339202000117