Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Donald M. Engelman"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The family of pH (Low) Insertion Peptides (pHLIP) comprises a tumor-agnostic technology that uses the low pH (or high acidity) at the surfaces of cells within the tumor microenvironment (TME) as a targeted biomarker. pHLIPs can be used for extracellu
Externí odkaz:
https://doaj.org/article/0640bfd124d14ebe93fca74d6839249c
Autor:
Anna Moshnikova, Michael DuPont, Marissa Iraca, Craig Klumpp, Hannah Visca, Dana Allababidi, Phoebe Pelzer, Donald M. Engelman, Oleg A. Andreev, Yana K. Reshetnyak
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: We have developed a delivery approach that uses two pHLIP peptides that collaborate in the targeted intracellular delivery of a single payload, dimeric STINGa (dMSA).Methods: dMSA was conjugated with two pHLIP peptides via S-S cleavable
Externí odkaz:
https://doaj.org/article/cc2c9e61698a43bcaa54c6a4266d80cc
Autor:
Michael DuPont, Hannah Visca, Anna Moshnikova, Donald M. Engelman, Yana K. Reshetnyak, Oleg A. Andreev
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2023)
Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to tumors by pH Low Insertion Peptides (pHLIPs), whic
Externí odkaz:
https://doaj.org/article/d700cf2a62f949bd8a77afe932e3ef4b
Autor:
Anna Moshnikova, Michael DuPont, Hannah Visca, Donald M. Engelman, Oleg A. Andreev, Yana K. Reshetnyak
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Despite significant progress in the development of novel STING agonists (STINGa), applications appear to be challenged by the low efficiency and poor selectivity of these agents. A pH Low Insertion Peptide (pHLIP) extends the lifetime of a STINGa in
Externí odkaz:
https://doaj.org/article/ab256117ad664387906ca35c82e6f673
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103208- (2021)
Summary: Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To investigate this phenom
Externí odkaz:
https://doaj.org/article/6558ce772050497a963f879c45a2d37f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other
Externí odkaz:
https://doaj.org/article/2cf5a66d3d8843e5b5f8a25fe7fc02a2
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The discovery of the pH Low Insertion Peptides (pHLIPs) provides an opportunity to develop imaging and drug delivery agents targeting extracellular acidity. Extracellular acidity is associated with many pathological states, such as those in cancer
Externí odkaz:
https://doaj.org/article/c9e3fbe7480c4eb6a55664d583577e61
Autor:
Jeffrey L, Brodsky, Donald M, Engelman, Linda M, Hendershot, Stefano, Piana-Agostinetti, Thomas, Sommer
Publikováno v:
Science
Misfolded luminal endoplasmic reticulum (ER) proteins undergo ER-associated degradation (ERAD-L): they are retro-translocated into the cytosol, poly-ubiquitinated, and degraded by the proteasome. ERAD-L is mediated by the Hrd1 complex (composed of Hr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d908f144ec2abe5a8e9010db399c1a2f
https://pubmed.ncbi.nlm.nih.gov/32327568
https://pubmed.ncbi.nlm.nih.gov/32327568
Autor:
Peter M. Glazer, Donald M. Engelman, Raman Bahal, Stanley Oyaghire, Yanfeng Liu, Ha Pham, Alanna R. Kaplan
The development of therapeutic agents that specifically target cancer cells while sparing healthy tissue could be used to enhance the efficacy of cancer therapy without increasing its toxicity. Specific targeting of cancer cells can be achieved throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967456cd8df7460b32a0e570d7849ead
https://doi.org/10.1158/1541-7786.c.6541771
https://doi.org/10.1158/1541-7786.c.6541771
Autor:
Peter M. Glazer, Donald M. Engelman, Raman Bahal, Stanley Oyaghire, Yanfeng Liu, Ha Pham, Alanna R. Kaplan
Fig. S1: pHLIP-αKu80(γ) binds to the mouse Ku80 sequence. Fig. S2: Validation of tumor vs. stromal cell sorting in EMT6-GFP cells. Fig. S3: Partial suppression of Ku80 expression induces radiosensitivity in cultured cancer cells. Fig. S4: pHLIP-αK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4823823498c3d5b7335c0675f8a5ce6e
https://doi.org/10.1158/1541-7786.22517572.v1
https://doi.org/10.1158/1541-7786.22517572.v1