Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Donald M. Black"'
Autor:
Donald M. Black, Taufiq Salahuddin, Jean-Claude Tardif, Lawrence A. Leiter, David Kallend, Philip J. Barter, Eran Leitersdorf, Stephen J. Nicholls, Christie M. Ballantyne, Anders G. Olsson, Prediman K. Shah, Gregory G. Schwartz, John Kittelson
Publikováno v:
American Heart Journal. 221:60-66
Background High-density lipoprotein cholesterol (HDL-C) concentration is inversely related to risk of major adverse cardiovascular events (MACE) in epidemiologic studies but is a poorer predictor of MACE in patients with established coronary heart di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5f308cff470276ad34fa952b3bc87
https://doi.org/10.1016/j.ahj.2019.12.003
https://doi.org/10.1016/j.ahj.2019.12.003
Autor:
Jean-Claude Tardif, J. Wouter Jukema, Frank M. Sacks, David Rhainds, Marie-Pierre Dubé, Fouzia Laghrissi-Thode, R. Scott Wright, Chris J. Packard, Eric J. Niesor, Mathieu R. Brodeur, Therese Heinonen, Marc A. Pfeffer, Donald M. Black, David D. Waters
Publikováno v:
Circ Genom Precis Med
Circulation: Genomic and Precision Medicine, 14(2), 258-268. LIPPINCOTT WILLIAMS & WILKINS
Circulation: Genomic and Precision Medicine, 14(2), 258-268. LIPPINCOTT WILLIAMS & WILKINS
Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 ( ADCY9 ) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c6be8a32b45374333751ea55a7e47a
https://doi.org/10.1161/circgen.121.003219
https://doi.org/10.1161/circgen.121.003219
Publikováno v:
Journal of cardiovascular pharmacology. 78(4)
Atherosclerosis has been effectively avoided with many therapies that lower low-density lipoprotein cholesterol. However, significant cardiovascular burden remains. The effect of raising high-density lipoprotein (HDL) has been confounded by other fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a97a3a8e823d3015a3bdd26cb78cc7
https://pubmed.ncbi.nlm.nih.gov/34173811
https://pubmed.ncbi.nlm.nih.gov/34173811
Autor:
Donald M. Black, Marie-Pierre Dubé, dal-GenE Investigators, Therese Heinonen, Marie-Claude Guertin, Jean-Claude Tardif, Harvey D. White, Aldo P. Maggioni, John J.V. McMurray, Marc A. Pfeffer, David D. Waters, Wolfgang Koenig, Vincent Mooser
The objectives of precision medicine are to better match patient characteristics with the therapeutic intervention to optimize the chances of beneficial actions while reducing the exposure to unneeded adverse drug experiences. In a retrospective geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e150b3f2aef70738be8b32f9d22ce7
https://eprints.gla.ac.uk/211666/1/211666.pdf
https://eprints.gla.ac.uk/211666/1/211666.pdf
Publikováno v:
Clinical Pharmacokinetics
The cholesterol ester transfer protein (CETP) inhibitor dalcetrapib has been under evaluation for its potential to prevent cardiovascular (CV) events for almost two decades. The current clinical development program, representing new advances in preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba6cca41232fed59776d323fab5c36
https://doi.org/10.1007/s40262-018-0656-3
https://doi.org/10.1007/s40262-018-0656-3
Autor:
Donald M. Black, Therese Heinonen
Publikováno v:
Clinical Investigation. 1:795-803
The purpose of this article is to review the current landscape of new therapeutic targets, advances in biomarkers and imaging technologies, regulatory sciences, and their collective potential impact on the development of novel anti-atherosclerosis dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7e54c8e672d9932307f953363c52b9
https://doi.org/10.4155/cli.11.64
https://doi.org/10.4155/cli.11.64
RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation
Publikováno v:
Cell Motility and the Cytoskeleton. 60:140-152
TES was originally identified as a candidate tumour suppressor gene and has subsequently been found to encode a novel focal adhesion protein. As well as localising to cell-matrix adhesions, TES localises to cell-cell contacts and to actin stress fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3437efbd8901bca0efd805ce28a0a71
https://doi.org/10.1002/cm.20052
https://doi.org/10.1002/cm.20052
Publikováno v:
Cell Motility and the Cytoskeleton. 57:133-142
Previously we identified TES as a candidate tumour suppressor gene that is located at human chromosome 7q31.1. More recently, we and others have shown TES to encode a novel LIM domain protein that localises to focal adhesions. Here, we present the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4406816c6bd5c9df2d2a389ed4f371f4
https://doi.org/10.1002/cm.10162
https://doi.org/10.1002/cm.10162
Autor:
Donald M Black
Publikováno v:
The American Journal of Cardiology. 91:40-43
The question of how much cholesterol in the blood is healthy has been one of considerable interest since the early 20th century. Although we have known for many years that high levels of LDL cholesterol (“bad cholesterol”), total cholesterol, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4ac008b698b3420cda2e8cbff9db97
https://doi.org/10.1016/s0002-9149(02)03387-8
https://doi.org/10.1016/s0002-9149(02)03387-8
Publikováno v:
Journal of Cell Science. 116:897-906
Previously, we identified TES as a novel candidate tumour suppressor gene that mapped to human chromosome 7q31.1. In this report we demonstrate that the TES protein is localised at focal adhesions, actin stress fibres and areas of cell-cell contact.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d0c21b2177a3c7f8966b4e81183c55
https://doi.org/10.1242/jcs.00278
https://doi.org/10.1242/jcs.00278