Zobrazeno 1 - 10
of 705
pro vyhledávání: '"Donald M Bers"'
Autor:
Marina Besprozvannaya, Eamonn Dickson, Hao Li, Kenneth S Ginburg, Donald M Bers, Johan Auwerx, Jodi Nunnari
Publikováno v:
eLife, Vol 7 (2018)
Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis. Previous work demonstrated that the highly conserved yeast Ltc/Lam sterol tr
Externí odkaz:
https://doaj.org/article/60c66a29d1814f5aa383d809ab92c5be
Autor:
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle. However, the structural dynamics by which calmod
Externí odkaz:
https://doaj.org/article/7cf35385c2e841cd82d95bed6b88e184
Autor:
Michael J. Bround, Eaman Abay, Jiuzhou Huo, Julian R. Havens, Allen J. York, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitoc
Externí odkaz:
https://doaj.org/article/112e99cf4854424d83eb6c5e44822e53
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/c5594865fb8449b8be83da25a6ec9fba
Autor:
Donald M Bers, Stefano eMorotti
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
The cardiac voltage gated Ca2+ current (ICa) is critical to the electrophysiological properties, excitation-contraction coupling, mitochondrial energetics and transcriptional regulation in heart. Thus, it is not surprising that cardiac ICa is regulat
Externí odkaz:
https://doaj.org/article/c6ffa789d1f543eda577e9a1cda5b81b
Autor:
Jerry Curran, Lifei Tang, Steve R Roof, Sathya Velmurugan, Ashley Millard, Stephen Shonts, Honglan Wang, Demetrio Santiago, Usama Ahmad, Matthew Perryman, Donald M Bers, Peter J Mohler, Mark T Ziolo, Thomas R Shannon
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87495 (2014)
Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors. Beta-adrenergic (β-AR) tone is known to increase this leak through the activation of Ca-calmodulin-dep
Externí odkaz:
https://doaj.org/article/aa8b8f476611492086b0aa2f08cc14ff
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85365 (2013)
Spatially discordant alternans (SDA) of action potential duration (APD) is a phenomenon where different regions of cardiac tissue exhibit an alternating sequence of APD that are out-of-phase. SDA is arrhythmogenic since it can induce spatial heteroge
Externí odkaz:
https://doaj.org/article/9d0407ff7e804bf29b2ddcd2bdba9746
Autor:
Jessica I Gold, Jeffrey S Martini, Jonathan Hullmann, Erhe Gao, J Kurt Chuprun, Linda Lee, Douglas G Tilley, Joseph E Rabinowitz, Julie Bossuyt, Donald M Bers, Walter J Koch
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57324 (2013)
G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte g
Externí odkaz:
https://doaj.org/article/f933052fcc7e42b0bf320c5f5af94e73
Autor:
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113465- (2023)
Summary: Mitochondria use the electron transport chain to generate high-energy phosphate from oxidative phosphorylation, a process also regulated by the mitochondrial Ca2+ uniporter (MCU) and Ca2+ levels. Here, we show that MCUb, an inhibitor of MCU-
Externí odkaz:
https://doaj.org/article/b65c0ce78b7040798c4078208b4eb116
Autor:
Kyung-Mi Choi, Christopher Y. Ko, Sung-Min An, Seung-Hee Cho, Douglas J. Rowland, Jung Hak Kim, Anna Fasoli, Abhijit J. Chaudhari, Donald M. Bers, John C. Yoon
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101679- (2023)
Objective: Cold stimuli trigger the conversion of white adipose tissue into beige adipose tissue, which is capable of non-shivering thermogenesis. However, what process drives this activation of thermogenesis in beige fat is not well understood. Here
Externí odkaz:
https://doaj.org/article/d7d3c5460b9a4a8d95a80c26712d06c5