Zobrazeno 1 - 10
of 644
pro vyhledávání: '"Donald M, Bers"'
Autor:
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle. However, the structural dynamics by which calmod
Externí odkaz:
https://doaj.org/article/7cf35385c2e841cd82d95bed6b88e184
Autor:
Michael J. Bround, Eaman Abay, Jiuzhou Huo, Julian R. Havens, Allen J. York, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitoc
Externí odkaz:
https://doaj.org/article/112e99cf4854424d83eb6c5e44822e53
Autor:
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113465- (2023)
Summary: Mitochondria use the electron transport chain to generate high-energy phosphate from oxidative phosphorylation, a process also regulated by the mitochondrial Ca2+ uniporter (MCU) and Ca2+ levels. Here, we show that MCUb, an inhibitor of MCU-
Externí odkaz:
https://doaj.org/article/b65c0ce78b7040798c4078208b4eb116
Autor:
Kyung-Mi Choi, Christopher Y. Ko, Sung-Min An, Seung-Hee Cho, Douglas J. Rowland, Jung Hak Kim, Anna Fasoli, Abhijit J. Chaudhari, Donald M. Bers, John C. Yoon
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101679- (2023)
Objective: Cold stimuli trigger the conversion of white adipose tissue into beige adipose tissue, which is capable of non-shivering thermogenesis. However, what process drives this activation of thermogenesis in beige fat is not well understood. Here
Externí odkaz:
https://doaj.org/article/d7d3c5460b9a4a8d95a80c26712d06c5
Autor:
Bence Hegyi, Juliana Mira Hernandez, Christopher Y. Ko, Junyoung Hong, Erin Y. Shen, Emily R. Spencer, Daria Smoliarchuk, Manuel F. Navedo, Donald M. Bers, Julie Bossuyt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 23 (2022)
Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited. Diabetes and mineralocorticoid excess are common and important pathophysiological factors that m
Externí odkaz:
https://doaj.org/article/f894cdcd88b24aaf9dd73caf14ff55d9
Autor:
Julie Bossuyt, Johanna M. Borst, Marie Verberckmoes, Logan R. J. Bailey, Donald M. Bers, Bence Hegyi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background Structural and electrophysiological remodeling characterize heart failure (HF) enhancing arrhythmias. PKD1 (protein kinase D1) is upregulated in HF and mediates pathological hypertrophic signaling, but its role in K+ channel remodeling and
Externí odkaz:
https://doaj.org/article/a20535135f97454bbf42416f5160752a
Autor:
Yankun Lyu, Phung N. Thai, Lu Ren, Valeriy Timofeyev, Zhong Jian, Seojin Park, Kenneth S. Ginsburg, James Overton, Julie Bossuyt, Donald M. Bers, Ebenezer N. Yamoah, Ye Chen-Izu, Nipavan Chiamvimonvat, Xiao-Dong Zhang
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103624- (2022)
Summary: The mammalian heart beats incessantly with rhythmic mechanical activities generating acids that need to be buffered to maintain a stable intracellular pH (pHi) for normal cardiac function. Even though spatial pHi non-uniformity in cardiomyoc
Externí odkaz:
https://doaj.org/article/71ec355c18ca46c0abb871b3e9983834
Autor:
Phung N. Thai, Charles V. Miller, M. Todd King, Saul Schaefer, Richard L. Veech, Nipavan Chiamvimonvat, Donald M. Bers, Elena N. Dedkova
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 19 (2021)
Background Heart failure is responsible for approximately 65% of deaths in patients with type 2 diabetes mellitus. However, existing therapeutics for type 2 diabetes mellitus have limited success on the prevention of diabetic cardiomyopathy. The aim
Externí odkaz:
https://doaj.org/article/14efa7dcf45f45d09137d5ef645178a1
Autor:
Donald M. Bers, Stanley Nattel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Externí odkaz:
https://doaj.org/article/7ad4924a40b34e15bc555b952b276ada
Autor:
Juliana Mira Hernandez, Christopher Y. Ko, Avery R. Mandel, Erin Y. Shen, Sonya Baidar, Ashley R. Christensen, Kim Hellgren, Stefano Morotti, Jody L. Martin, Bence Hegyi, Julie Bossuyt, Donald M. Bers
Publikováno v:
Journal of Molecular and Cellular Cardiology. 180:33-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d38fd5b41fc215eb10e7e61eeb83dfc
https://doi.org/10.1016/j.yjmcc.2023.05.001
https://doi.org/10.1016/j.yjmcc.2023.05.001