Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Donald L. Martin"'
Autor:
Donald L. Martin
An Ownership Theory of the Trade Union explores the economic theories behind trade union behavior, analyzing the historical struggle to define what unions maximize. Despite various theories suggesting unions aim to maximize wage rates, membership ben
Publikováno v:
Precision Engineering. 34:85-91
This paper demonstrates the application of two methods of separating spindle error motion from artifact roundness on a spindle with
Autor:
Donald L. Martin, John Geweke
Publikováno v:
Journal of Risk and Uncertainty. 25:111-131
Measuring the impact of potentially controllable factors on the willingness of youth to undertake health risks is important to informed public health policy decisions. Typically the only data linking these factors with risk-taking behavior are retros
Autor:
Donald L. Martin, Richard S. Higgins
Publikováno v:
SSRN Electronic Journal.
This paper discusses a method for evaluating the competitive effects of reverse payments in the wake of the Supreme Court’s Opinion in Actavis. Specifically, we demonstrate a method for evaluating actual reverse payments against a “maximum-effici
Autor:
Donald L. Martin, Richard S. Higgins
Publikováno v:
SSRN Electronic Journal.
This paper focuses on the implications for royalty determination of the latest expression of the Entire Market Value Rule (EMVR) and its usefulness in guiding damage estimation in the context of complex products whose components are protected by inte
Autor:
Kenneth M. Verburg, Thomas J. Perun, Vered Klinghofer, Herman H. Stein, David A. Egan, Daniel J. Hoffman, William R. Baker, Yoek Lin Armiger, Boyd Steven A, Anthony K. L. Fung, Robert A. Mantei, Donald L. Martin, Kevin W. Garren, Jerome Cohen, James S. Polakowski, Gary A. Young, Hollis D. Kleinert, Jennifer L. Barlow
Publikováno v:
Journal of Medicinal Chemistry. 35:1735-1746
We describe the development of a series of soluble, potent, and bioavailable nonpeptide renin inhibitors. These inhibitors derived from a series of novel nonpeptide renin inhibitors which were recently identified in our laboratories, by alteration of
Autor:
Donald L. Martin, Carl De Meyer
Publikováno v:
SSRN Electronic Journal.
The choice of method for allocating royalties among intellectual property ("IP") owning members of a standards setting organization ("SSO") has substantive implications for investment in technological innovation, the allocation of resources between t
Autor:
Jerome Cohen, Saul H. Rosenberg, Jennifer L. Barlow, Donald L. Martin, David A. Egan, James S. Polakowski, Kenneth P. Spina, Herman H. Stein, Keith W. Woods, Yao Z
Publikováno v:
Journal of medicinal chemistry. 36(4)
A systematic evaluation of structure-absorption relationships using a high throughput intraduodenal rat screening model has led to the delineation of a set of structural parameters that appear to govern bioavailability in a series of peptide-based re
Autor:
James S. Polakowski, David A. Egan, Jerome Cohen, Jennifer L. Barlow, Donald L. Martin, Thomas J. Perun, Kenneth M. Verburg, Jacob J. Plattner, Yoek Lin Armiger, Boyd Steven A, Anthony K. L. Fung, William R. Baker, Herman H. Stein, Gary A. Young, Stephen Condon, Hollis D. Kleinert
Publikováno v:
Journal of medicinal chemistry. 35(10)
A new series of renin inhibitors has been developed. The inhibitors feature a novel replacement for the P2/P3 dipeptide moiety normally associated with renin inhibitors. The dipeptide replacement was a (2S,4S)-3-aza(or oxa)-2,4-dialkylglutaric acid a
Autor:
I Merits, Keith W. Woods, Jerry Cohen, David A. Egan, Barbara A. Bopp, H. L. Sham, Donald L. Martin, Hollis D. Kleinert, Herman H. Stein, Saul H. Rosenberg
Publikováno v:
Journal of medicinal chemistry. 33(7)
Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of ac