Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Donald L. Lodmell"'
Publikováno v:
Vaccine. 22:3329-3333
Presently, commercially available cell culture rabies vaccines for humans and animals consist of the five inactivated rabies virus proteins. The vaccines elicit a CD4+ helper T-cell response and a humoral B-cell response against the viral glycoprotei
Publikováno v:
Vaccine. 21:3998-4002
Rabid dog exposures cause >99% of human rabies deaths world-wide. In developing countries, where dogs are the viral reservoir, the 30-50% vaccination coverage of dog populations is insufficient to break the disease transmission cycle. In addition, ma
Autor:
Larry C. Ewalt, Donald L. Lodmell
Publikováno v:
Vaccine. 19:2468-2473
Post-exposure anti-rabies vaccination for individuals who have not previously been immunized against rabies includes a cell culture-derived vaccine and a one time injection of rabies immune globulin. Recent studies have shown DNA vaccinations to be h
Autor:
Larry C. Ewalt, Donald L. Lodmell
Publikováno v:
Vaccine. 18:2394-2398
Long-term levels of neutralizing antibody were evaluated in mice after a single immunization with experimental DNA or recombinant vaccinia virus (RVV) vaccines encoding the rabies virus glycoprotein (G), or the commercially available inactivated viru
Autor:
Donald L. Lodmell
Publikováno v:
Expert Opinion on Investigational Drugs. 8:115-122
Rabies is a successful zoonotic disease that has persisted over time, achieving worldwide distribution in a variety of species. Annually, in developing countries with limited access to high-quality antirabies biologics, approximately 50,000 individua
Publikováno v:
Vaccine. 16:115-118
Accell gene gun particle-mediated immunization with DNA encoding the glycoprotein gene of the challenge virus standard strain of rabies virus was evaluated for its ability to elicit protective levels of serum anti-rabies virus neutralizing antibody.
Publikováno v:
Vaccine. 15:892-895
Vaccination against virus infections has proven to be an effective strategy in the improvement of human health. In this study, we evaluated two plasmid DNA vaccines expressing the glycoprotein (G) gene of the challenge virus standard (CVS) rabies vir
Publikováno v:
Archives of Virology
Summary Recent studies have reported the detection of rabies viral antigens and virions in astrocytes and microglia of rabies-infected animals. As a first step toward understanding whether these glial cells may be involved in rabies virus replication
Autor:
Donald L. Lodmell, Larry C. Ewalt
Publikováno v:
Vaccine. 22:3237-3239
Human exposure to rabid dogs in developing countries is an ongoing problem that continues to demand effective, safe, and affordable post-exposure rabies vaccinations. Sheep and suckling mouse brain rabies vaccines used in developing countries are bei
Publikováno v:
Journal of Virology. 67:6080-6086
We previously reported that A/WySnJ mice vaccinated via a tail scratch with a recombinant raccoon poxvirus (RCN) expressing the rabies virus internal structural nucleoprotein (N) (RCN-N) were protected against a street rabies virus (D. L. Lodmell, J.