Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Donald L Gill"'
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/bacfc4e9fb7f4dd8bf3716d520a39baf
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 9 (2020)
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca2+ (mtCa2+) regulates tumorigenesis remain incompletely understood. The crucial role of mtCa2+ in tumorigenesis is highlighted by altered expression of pr
Externí odkaz:
https://doaj.org/article/5281232761db416a876d72cbe79942a1
Autor:
Yandong Zhou, Robert M Nwokonko, James H Baraniak, Mohamed Trebak, Kenneth P K Lee, Donald L Gill
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000413 (2019)
Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth. The ubiquitously expressed Orai family of plasma membrane (PM) ion channels mediate Ca2+ entry signals triggered
Externí odkaz:
https://doaj.org/article/60cb9b5346a049658c3c68749a95892e
Autor:
Sisi Zheng, Guolin Ma, Lian He, Tian Zhang, Jia Li, Xiaoman Yuan, Nhung T Nguyen, Yun Huang, Xiaoyan Zhang, Ping Gao, Robert Nwokonko, Donald L Gill, Hao Dong, Yubin Zhou, Youjun Wang
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e2006898 (2018)
The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent p
Externí odkaz:
https://doaj.org/article/02baa7431c934d49906e1405d2bdf6ed
Autor:
Yandong Zhou, Michelle R. Jennette, Guolin Ma, Sarah A. Kazzaz, James H. Baraniak, Robert M. Nwokonko, Mallary L. Groff, Marcela Velasquez-Reynel, Yun Huang, Youjun Wang, Donald L. Gill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but undefined mechanism. We identify two unusual overlapping Phe-His a
Externí odkaz:
https://doaj.org/article/9a0a51890d4548619de4b07244d682f4
Autor:
Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Martin T. Johnson, Adam J. Fike, Vonn Walter, Nadine Hempel, David I. Yule, James Sneyd, Donald L. Gill, Mohamed Trebak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of
Externí odkaz:
https://doaj.org/article/d0bad2674967414e8be76ad70168e97d
Autor:
Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103339- (2021)
Summary: Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M
Externí odkaz:
https://doaj.org/article/07366b1458be4b4bbeed13ff5fe16ed8
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Autor:
Xuexin Zhang, Trayambak Pathak, Ryan Yoast, Scott Emrich, Ping Xin, Robert M. Nwokonko, Martin Johnson, Shilan Wu, Céline Delierneux, Maxime Gueguinou, Nadine Hempel, James W. Putney, Donald L. Gill, Mohamed Trebak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling cross
Externí odkaz:
https://doaj.org/article/273145bab6b34b6fac4674fdd0ecc38c
Autor:
Neeharika Nemani, Edmund Carvalho, Dhanendra Tomar, Zhiwei Dong, Andrea Ketschek, Sarah L. Breves, Fabián Jaña, Alison M. Worth, Julie Heffler, Palaniappan Palaniappan, Aparna Tripathi, Ramasamy Subbiah, Massimo F. Riitano, Ajay Seelam, Thomas Manfred, Kie Itoh, Shuxia Meng, Hiromi Sesaki, William J. Craigen, Sudarsan Rajan, Santhanam Shanmughapriya, Jeffrey Caplan, Benjamin L. Prosser, Donald L. Gill, Peter B. Stathopulos, Gianluca Gallo, David C. Chan, Prashant Mishra, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1005-1019 (2018)
Summary: Mitochondria shape cytosolic calcium ([Ca2+]c) transients and utilize the mitochondrial Ca2+ ([Ca2+]m) in exchange for bioenergetics output. Conversely, dysregulated [Ca2+]c causes [Ca2+]m overload and induces permeability transition pore an
Externí odkaz:
https://doaj.org/article/d8a52722cb5c491eaab6dfcbe01c7e01
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants
Externí odkaz:
https://doaj.org/article/7442bfde707e4e3ebdaa7b0c56fea71b