Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Donald K, Blumenthal"'
Autor:
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric c
Externí odkaz:
https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e
Autor:
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia
Publikováno v:
eLife, Vol 9 (2020)
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Externí odkaz:
https://doaj.org/article/34c13da9463648a9980c22009c9c1bf8
Autor:
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Sanford M. Simon, Susan S. Taylor, Gianluigi Veglia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006-3
Externí odkaz:
https://doaj.org/article/7c24fd9db8f04d64a2a736102b658354
Autor:
Xiaolin Cheng, Carlo Ballatore, Xiaotian Kong, Zoran Radić, Palmer Taylor, Lukas Gorecki, Andrey Kovalevsky, Donald K. Blumenthal, Oksana Gerlits
Publikováno v:
The Journal of biological chemistry, vol 295, iss 13
J Biol Chem
J Biol Chem
Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4649c3e494b09cb5e29a444296e402ce
https://doi.org/10.1074/jbc.ra119.012400
https://doi.org/10.1074/jbc.ra119.012400
Autor:
Oksana, Gerlits, Mikolai, Fajer, Xiaolin, Cheng, Donald K, Blumenthal, Zoran, Radić, Andrey, Kovalevsky
Publikováno v:
Structure. 30:1538-1549.e3
Organophosphorus (OP) compounds, including nerve agents and some pesticides, covalently bind to the catalytic serine of human acetylcholinesterase (hAChE), thereby inhibiting acetylcholine hydrolysis necessary for efficient neurotransmission. Oxime a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26207fbde3999e2ea3fe56810bf73f2
https://doi.org/10.1016/j.str.2022.09.006
https://doi.org/10.1016/j.str.2022.09.006
Autor:
Palmer Taylor, Andrey Kovalevsky, Donald K. Blumenthal, Zoran Radić, Mikolai Fajer, Puneet Juneja, Kwok-Yiu Ho, Jacqueline Rohrer, Oksana Gerlits, Xiaolin Cheng
Publikováno v:
The Journal of biological chemistry, vol 297, iss 3
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Acetylcholinesterase (EC 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03351602374b055c8336577d63112ba
https://escholarship.org/uc/item/46z0j5wg
https://escholarship.org/uc/item/46z0j5wg
Autor:
Simon M. Sandford, Fernando Porcelli, Cristina Olivieri, V. S. Manu, David D. Thomas, Donald K. Blumenthal, Susan S. Taylor, Caitlin Walker, Yingjie Wang, Gianluigi Veglia, David A. Bernlohr, Adak Karamafrooz
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
An aberrant fusion of the DNAJB1 and PRKACA genes generates a chimeric protein kinase (PKA-CDNAJB1) in which the J-domain of the heat shock protein 40 is fused to the catalytic α subunit of cAMP-dependent protein kinase A (PKA-C). Deceivingly, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddef787b3b19f9011cc55607bf5fa7f3
http://europepmc.org/articles/PMC7946884
http://europepmc.org/articles/PMC7946884
Autor:
Xiaotian Kong, Andrey Kovalevsky, Donald K. Blumenthal, Carlo Ballatore, Lukas Gorecki, Xiaolin Cheng, Oksana Gerlits, Palmer Taylor, Zoran Radić
Publikováno v:
Proceedings of The 2nd International Online Conference on Crystals.
Nucleophilic oxime reactivators of organophosphate (OP) inhibited human acetylcholinesterase (hAChE) are reactivating antidotes against OP intoxication from nerve agent (e.g., VX, sarin) or OP pesticide (e.g., paraoxon) exposure. Within the past deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edadd41d8ea28b947bd8e4890a2badc4
https://doi.org/10.3390/iocc_2020-08037
https://doi.org/10.3390/iocc_2020-08037
Autor:
Palmer Taylor, Andrey Kovalevsky, Donald K. Blumenthal, Xiaolin Cheng, Zoran Radić, Oksana Gerlits
Publikováno v:
Proceedings of The 2nd International Online Conference on Crystals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::145dd9c900a76e575c37b339db249051
https://doi.org/10.3390/iocc_2020-07323
https://doi.org/10.3390/iocc_2020-07323
Autor:
Gianluigi Veglia, Cristina Olivieri, Manu V S, Benjamin R Stultz, Fernando Porcelli, Geoffrey Li, Joseph M. Muretta, Donald K. Blumenthal, Jonggul Kim, Susan S. Taylor, Yingjie Wang, Jiali Gao, Matthew Neibergall, David D. Thomas
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fbc6a9abdbb256fc5bf2bdd6668d7a
https://doi.org/10.7554/elife.55607
https://doi.org/10.7554/elife.55607