Výsledky vyhledávání - "Donald J.A. Sutherland"

Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter

Autor: Michael A. Levesque, Barry Hoffman, Bhupinder Bharaj, Eleftherios P. Diamandis, Donald J.A. Sutherland, Maurizia Giai, Andreas Scorilas

Publikováno v: Breast Cancer Research and Treatment. 61:111-119

Prostate Specific Antigen (PSA) expression by breast epithelial cells is associated with favorable breast cancer prognosis. In preliminary studies, we found that a nucleotide variation (G-->A) at position -158 in the androgen response element (ARE-1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffece2892e0587805fe99b229a77be45
https://doi.org/10.1023/a:1006459613498

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Expression of a prostate-associated protein, human glandular kallikrein (hK2), in breast tumours and in normal breast secretions

Autor: Angeliki Magklara, Christina V. Obiezu, Margot H. Black, Donald J.A. Sutherland, D J Tindall, Michael A. Levesque, C Y F Young, Eleftherios P. Diamandis, Edward R. Sauter

Publikováno v: British Journal of Cancer

The recent demonstration of human glandular kallikrein (hK2) expression in a breast carcinoma cell line has suggested that this putatively prostate-restricted, steroid hormone-regulated protease may also be expressed in breast epithelium in vivo and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c3d586336429527f91b594ea01eb44
http://europepmc.org/articles/PMC2363279

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neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group

Publikováno v: Journal of Clinical Oncology. 16:1340-1349

PURPOSE It remains a challenge to predict which women with axillary node-negative (ANN) breast cancer at greatest risk of relapse may benefit most from adjuvant therapy. Increases in neu/erbB-2 have been implicated in breast cancer prognosis. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427fccecc2ecf18272c8f245371eb37f
https://doi.org/10.1200/jco.1998.16.4.1340

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Quantification of creatine kinase BB isoenzyme in tumor cytosols and serum with an ultrasensitive time-resolved immunofluorometric technique

Autor: Eleftherios P. Diamandis, He Yu, Donald J.A. Sutherland, Nosratollah Zarghami

Publikováno v: Clinical biochemistry. 28(3)

To develop a highly sensitive immunofluorometric procedure for creatine kinase BB isoenzyme and use it to measure CK-BB in tumor cytosolic extracts and serum of cancer patients and healthy volunteers.For assay development, we used two monoclonal anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa0c0882cb9fd77b8d12d6992ab171e
https://pubmed.ncbi.nlm.nih.gov/7554242

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Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age

Autor: Donald J.A. Sutherland, He Yu, Eleftherios P. Diamandis

Publikováno v: Clinical biochemistry. 27(2)

Prostate-specific antigen (PSA) is believed to be a highly specific marker for normal or cancerous prostatic tissue. We recently found that immunoreactive PSA (IR-PSA) is present in 30% of breast tumor cytosols (from 525 breast cancer patients). In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1eb554f7f6201fb79391fcc5488e6fe
https://pubmed.ncbi.nlm.nih.gov/7520846

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Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer

Autor: He Yu, Eleftherios P. Diamandis, Michael A. Levesque, Donald J.A. Sutherland

Publikováno v: Breast cancer research and treatment. 30(2)

Breast tumors are thought to originate, grow, and metastasize in an environment which includes steroid hormone receptors, their cognate steroid ligands, and many gene products which are regulated by steroid hormone receptor-ligand complexes. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416937808f25b4ddc2c2c36b53da16a9
https://pubmed.ncbi.nlm.nih.gov/7524772

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Detection of prostate-specific antigen immunoreactivity in breast tumors

Autor: Eleftherios P. Diamandis, Donald J.A. Sutherland, He Yu

Publikováno v: Breast cancer research and treatment. 32(3)

Prostate-specific antigen (PSA) is a glycoprotein produced by the epithelial cells of the prostate. PSA is currently used in clinical practice to facilitate diagnosis and monitoring of prostate carcinoma. The prostate is an organ that possesses andro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338c666d1d3d637687e52ee2224e8490
https://pubmed.ncbi.nlm.nih.gov/7532468

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The standardization of estrogen receptors

Autor: Donald J.A. Sutherland, Judy-Anne W. Chapman, Eugene R. Tustanoff, Maureen E. Trudeau, Eamonn D. Ryan, H. Lavina A. Lickley, Wedad Hanna, Teik Chye Ooi, Carol Sawka, David R. McCready, Kathleen I. Pritchard, B.G. Mobbs

Publikováno v: The Journal of steroid biochemistry and molecular biology. 45(5)

Tumour estrogen receptor (ER) status may determine the medical treatment of a patient with breast cancer; yet inter-laboratory results can vary markedly, particularly when absolute cut-offs in fmol/mg cytosol protein are used. The use of standardized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0684d97ebc857f4f7d839290debc4c92
https://pubmed.ncbi.nlm.nih.gov/7684604

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Evidence for bimodal distribution of breast carcinoma ER and PgR values quantitated by enzyme immunoassay

Autor: Judy-Anne W. Chapman, Donald J.A. Sutherland, Eamonn D. Ryan, Eugene R. Tustanoff, B.G. Mobbs, P.V.Narasimha Murthy, Teik Chye Ooi

Publikováno v: European journal of cancer (Oxford, England : 1990). (9)

Breast carcinoma oestrogen receptor (ER) and progesterone receptor (PgR) values obtained by radioligand binding assays have commonly been observed to have approximate log-normal distributions. We examined the distribution of log-transformed receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ba49326bd95d7e222e0954da5f28f5
https://pubmed.ncbi.nlm.nih.gov/8343271

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