Výsledky vyhledávání - "Donald J. Reed"

Autor: Donald J. Reed

Publikováno v: Molecular and Cellular Mechanisms of Toxicity ISBN: 9780429277603

Studies on the mechanisms of oxygen toxicity have led to a greater understanding of oxidative stress-induced toxicity. Chemicals that are known to undergo redox cycling can cause oxidative stress to such a degree that they play a major role in chemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca170773f6c9f34a65ef28dfc7a7a205
https://doi.org/10.1201/9780429277603-3

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Beyond the War on Terror: Into the Fifth Generation of War and Conflict

Autor: Donald J. Reed

Publikováno v: Studies in Conflict & Terrorism. 31:684-722

Fifth generation warfare has arrived and is irreversibly changing the character and nature of human conflict. It confronts the United States with the evolving strategic dilemma of not only dealing with the War on Terror, but of simultaneously craftin

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https://doi.org/10.1080/10576100802206533

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Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol

Autor: Donald J. Reed

Publikováno v: Drug Metabolism Reviews. 36:569-582

The mechanisms of alcohol toxicity as related to mitochondrial dysfunction and the glutathione-dependent protective systems are reviewed. The pathophysiology of ethanol-induced liver damage is defined in terms of an early phase and a late phase. CYP2

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https://doi.org/10.1081/dmr-200033449

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Intramolecular Interactions in Chemically Modified Escherichia coli Thioredoxin Monitored by Hydrogen/Deuterium Exchange and Electrospray Ionization Mass Spectrometry

Autor: Max L. Deinzer, Ho Ps, Donald J. Reed, Claudia S. Maier, † Moo-Young Kim

Publikováno v: Biochemistry. 40:14413-14421

Site specific amide hydrogen/deuterium content of oxidized and reduced Escherichia colithioredoxin, and alkylated derivatives, Cys-32-ethylglutathionylated and Cys-32-ethylcysteinylated thioredoxins are measured, after exposure for 20 s to D(2)O/phos

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https://doi.org/10.1021/bi0115941

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Conjugative metabolism of 1,2-dibromoethane in mitochondria: disruption of oxidative phosphorylation and alkylation of mitochondrial DNA

Autor: Donald J. Reed, Carin Thomas, Dawn Sanderlin, Yvonne Will, Saundra L. Schoenberg

Publikováno v: Biochemical Pharmacology. 61:595-603

1,2-Dibromoethane (DBE) is an environmental contaminant that is metabolized by glutathione S-transferases to a haloethane–glutathione conjugate. Since haloethane–glutathione conjugates are known to alkylate nuclear DNA and cytoplasmic proteins, t

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https://doi.org/10.1016/s0006-2952(00)00577-3

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γ-Glutamyltranspeptidase–Deficient Knockout Mice as a Model to Study the Relationship Between Glutathione Status, Mitochondrial Function, and Cellular Function

Autor: Yvonne Will, Olaf R. Hedstrom, Kay A. Fischer, Michael W. Lieberman, Robert A. Horton, Donald J. Reed, Marda K. Brown, Rhonda S. Kaetzel

Publikováno v: Hepatology. 32:740-749

γ-Glutamyltranspeptidase (GGT)-deficient mice (GGT−/−) display chronic glutathione (GSH) deficiency, growth retardation, and die at a young age (

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https://doi.org/10.1053/jhep.2000.17913

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γ-Glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses

Autor: Yvonne Will, B. Paige Lawrence, Nancy I. Kerkvliet, Donald J. Reed

Publikováno v: European Journal of Immunology. 30:1902-1910

Gamma-Glutamyltranspeptidase (GGT) catalyzes the first step in the extracellular hydrolysis of glutathione (GSH) and plays a critical role in GSH recycling; however, little is known about the impact of diminished GGT activity on immune function. We r

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https://doi.org/10.1002/1521-4141(200007)30:7<1902::aid-immu1902>3.0.co

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Biliary Secretion of α-Tocopherol and the Role of the mdr2 P-Glycoprotein in Rats and Mice

Autor: Jefry E. Shields, Debbie J. Mustacich, Marda K. Brown, Donald J. Reed, Robert A. Horton

Publikováno v: Archives of Biochemistry and Biophysics. 350:183-192

The mechanism by which alpha-tocopherol (alpha-T) is secreted into the bile is not known; however, we have previously demonstrated that treatment with piperonyl butoxide (PIP, 1 g/kg) results in increased biliary output of both alpha-T and phosphatid

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https://doi.org/10.1006/abbi.1997.0529

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REACTION OF HUMAN HEMOGLOBIN TOWARD THE ALKYLATING AGENT S-(2-CHLOROETHYL)GLUTATHIONE

Autor: John C. L. Erve, Max L. Deinzer, Donald J. Reed

Publikováno v: Journal of Toxicology and Environmental Health Part A. 49:127-144

In order to investigate if hemoglobin might serve as a biomarker of exposure for 1,2-dichloroethane (DCE) encountered in the workplace, human hemoglobin was alkylated at physiologic pH by the episulfonium ion of S-(2-chloroethyl)glutathione (CEG). In

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https://doi.org/10.1080/009841096160880

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