Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Donald J. Piegors"'
Autor:
Donald D. Heistad, Francis J. Miller, Steven R. Lentz, José A. Fernández, Rochelle A. Erger, John H. Griffin, Donald J. Piegors
Publikováno v:
Circulation. 106:842-846
Background— Diet-induced atherosclerosis in monkeys produces abnormal anticoagulant responses to thrombin, including decreased generation of activated protein C (APC). We tested the hypothesis that anticoagulant responses to thrombin increase towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb5c035d89b973b5637b942dd4b9719
https://doi.org/10.1161/01.cir.0000024982.11646.25
https://doi.org/10.1161/01.cir.0000024982.11646.25
Publikováno v:
Circulation Research. 90:277-283
Superoxide (O 2 ·− ) in arteries may contribute to atherosclerosis in part by inactivation of nitric oxide. We hypothesized that regression of atherosclerosis in nonhuman primates is associated with a decrease in vascular NAD(P)H oxidase, decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4ebcd8f815a1b93839061f2e102b42
https://doi.org/10.1161/hh0302.104724
https://doi.org/10.1161/hh0302.104724
Publikováno v:
Circulation. 103:1006-1011
Background —Hyperhomocysteinemia is associated with increased risk of atherosclerotic and thrombotic vascular disease. In many patients, hyperhomocysteinemia can be treated or prevented by dietary supplementation with B vitamins, but the clinical b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a2dec84f5131682fb3d210935b6f2f
https://doi.org/10.1161/01.cir.103.7.1006
https://doi.org/10.1161/01.cir.103.7.1006
Autor:
Donald J. Piegors, M Y Bhopatkar, Christopher G. Sobey, Steven R. Lentz, Donald D. Heistad, Frank M. Faraci, M R Malinow
Publikováno v:
Journal of Clinical Investigation. 98:24-29
Elevated plasma homocyst(e)ine may predispose to complications of vascular disease. Homocysteine alters vasomotor regulatory and anticoagulant properties of cultured vascular endothelial cells, but little is known about effects of hyperhomocyst(e)ine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34288055336b5acc6620a08d8abf2f8c
https://doi.org/10.1172/jci118771
https://doi.org/10.1172/jci118771
Autor:
Donald J. Piegors, Andreas Mügge, Mark L. Armstrong, Peter Densen, Donald D. Heistad, J.Antonio G. Lopez, Richard C. Padgett
Publikováno v:
Atherosclerosis. 95:211-222
Activated leukocytes release a variety of substances which have been shown in vitro to modulate vascular tone. The chemotactic peptide complement C5a is a physiological activator of leukocytes. We injected human recombinant complement C5a (10 and 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae299a80f33c82cdbc32e120a150716
https://doi.org/10.1016/0021-9150(92)90024-b
https://doi.org/10.1016/0021-9150(92)90024-b
Autor:
John H. Griffin, Nigel S. Key, Arne Slungaard, Donald J. Piegors, Janel R. Long, José A. Fernández, Steven R. Lentz
Publikováno v:
Blood. 102(1)
Platelet factor 4 (PF4), an abundant platelet α-granule protein, accelerates in vitro generation of activated protein C (APC) by soluble thrombin/thrombomodulin (TM) complexes up to 25-fold. To test the hypothesis that PF4 similarly stimulates endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec58949a5c230a960c589fc2943d0b0
https://pubmed.ncbi.nlm.nih.gov/12609838
https://pubmed.ncbi.nlm.nih.gov/12609838
Autor:
Donald D. Heistad, John H. Griffin, William G. Haynes, Erland Arning, M. Rene Malinow, José A. Fernández, Steven R. Lentz, Rochelle A. Erger, Teodoro Bottiglieri, Donald J. Piegors
Publikováno v:
Blood. 100(6)
Hyperhomocysteinemia has been proposed to inhibit the protein C anticoagulant system through 2 mechanisms: decreased generation of activated protein C (APC) by thrombin, and resistance to APC caused by decreased inactivation of factor Va (FVa). We te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b4ef6ffd21344812e064f4d0b463f4
https://pubmed.ncbi.nlm.nih.gov/12609965
https://pubmed.ncbi.nlm.nih.gov/12609965
Autor:
José A. Fernández, Donald D. Heistad, M R Malinow, Donald J. Piegors, Steven R. Lentz, Rochelle A. Erger, John H. Griffin
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 19(7)
Abstract —To examine the effects of atherosclerosis on the protein C anticoagulant pathway in vivo, we measured anticoagulant responses to intravenous administration of human α-thrombin or activated protein C (APC) in cynomolgus monkeys. Two group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c7ebaa579518cee175e82904c2b385
https://pubmed.ncbi.nlm.nih.gov/10397693
https://pubmed.ncbi.nlm.nih.gov/10397693
Autor:
Frank M. Faraci, Donald D. Heistad, Steven R. Lentz, M Bhopatkar-Teredesai, Donald J. Piegors, M R Malinow
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 17(11)
Abstract Moderate elevation of plasma homocyst(e)ine is associated with increased risk for atherosclerotic vascular disease. In a previous study, we observed impaired vascular function in nonatherosclerotic monkeys with moderate hyperhomocyst(e)inemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a033d738f36f45d9c966ae5bfc9a1a
https://pubmed.ncbi.nlm.nih.gov/9409278
https://pubmed.ncbi.nlm.nih.gov/9409278
Publikováno v:
Stroke. 27(5)
Background and Purpose This study tested the hypothesis that functional abnormalities of carotid and ocular arteries may improve after short-term regression of atherosclerosis, before regression of structural abnormalities. Methods We examined effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20d80187a3aa4159fbfae001c134d93
https://pubmed.ncbi.nlm.nih.gov/8623115
https://pubmed.ncbi.nlm.nih.gov/8623115