Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donald J. McGuire"'
Autor:
William H. Hudson, Nataliya Prokhnevska, Julia Gensheimer, Rama Akondy, Donald J. McGuire, Rafi Ahmed, Haydn T. Kissick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Long noncoding RNA (lncRNA) genes do not encode protein products yet are emerging as key regulators of cellular processes such as transcription and translation. Here, by examining lncRNA profiles from human and mouse CD8 T cells, the authors show tha
Externí odkaz:
https://doaj.org/article/3fba6bfb088047b99a9728dd3fed18bd
Autor:
Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1282-1291.e5 (2020)
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RB
Externí odkaz:
https://doaj.org/article/d69652ad5ff041889716115077fdfc7b
Autor:
Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn T. Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James L. Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jorg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed
Publikováno v:
Nature. 610:173-181
Autor:
Amanda L. Gill, William H. Hudson, Rajesh M. Valanparambil, Eunseon Ahn, Donald J. McGuire, Andreas Wieland, Daniel T. McManus, Haydn T. Kissick, Rama S. Akondy, Rafi Ahmed
Publikováno v:
J Virol
Increased demand for novel, highly effective vaccination strategies necessitates a better understanding of long-lived memory CD8 T cell differentiation. To achieve this understanding, we used the mouse model of acute lymphocytic choriomeningitis viru
Autor:
Veronika I. Zarnitsyna, Rustom Antia, Hasan Ahmed, Marc K. Hellerstein, Rafi Ahmed, Philip L. F. Johnson, Donald J. McGuire, Vladimir G. Zarnitsyn, Kelvin W. Li, Rama Akondy, Mia Moore
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009468 (2021)
PLoS Computational Biology
PLoS Computational Biology
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effe
Autor:
Masao, Hashimoto, Koichi, Araki, Maria A, Cardenas, Peng, Li, Rohit R, Jadhav, Haydn T, Kissick, William H, Hudson, Donald J, McGuire, Rebecca C, Obeng, Andreas, Wieland, Judong, Lee, Daniel T, McManus, James L, Ross, Se Jin, Im, Junghwa, Lee, Jian-Xin, Lin, Bin, Hu, Erin E, West, Christopher D, Scharer, Gordon J, Freeman, Arlene H, Sharpe, Suresh S, Ramalingam, Alex, Pellerin, Volker, Teichgräber, William J, Greenleaf, Christian, Klein, Jorg J, Goronzy, Pablo, Umaña, Warren J, Leonard, Kendall A, Smith, Rafi, Ahmed
Publikováno v:
Nature
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection(1). Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, unlike PD-1 monot
Autor:
Rustom Antia, Yun Min Chang, Andreas Wieland, Donald J. McGuire, Se Jin Im, Rafi Ahmed, Zheng-Rong Li, Haydn T. Kissick
Publikováno v:
J Virol
Recent studies on chronic viral infections have defined a novel programmed cell death 1-positive (PD-1(+)) T cell factor 1-positive (TCF1(+)) stem-like CD8 T cell subset that gives rise to the terminally differentiated exhausted CD8 T cells. In this
Autor:
Donald J. McGuire, Rajesh M. Valanparambil, Se Jin Im, Mehrdad Alemozaffar, Christopher P. Filson, Caroline S. Jansen, Rama Akondy, Yun Min Chang, Ross Lake, Yuan Liu, Maria Cardenas, Kevin Richard Melnick, Adam G. Sowalsky, Haydn T. Kissick, Patrick Mullane, Jennifer W Carlisle, Nataliya Prokhnevska, Carla LaShannon Ellis, Martin G. Sanda, Scott Wilkinson, Adeboye O. Osunkoya, Amir Ishaq Khan, Viraj A. Master, Alice Kim, Mehmet Asim Bilen, Alice O. Kamphorst, Adriana Moon Reyes, William H. Hudson, Kyu Seo Kim
Publikováno v:
Nature
Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy1–8. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear. Here w
Autor:
Rafi Ahmed, William H. Hudson, Donald J. McGuire, Nataliya Prokhnevska, Julia Gensheimer, Rama Akondy, Haydn T. Kissick
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In response to viral infection, CD8+ T cells undergo expansion and differentiate into distinct classes of effector cells. After clearance of the virus, a small population of long-lived memory cells persists. Comprehensive studies have defined the pro
Autor:
Amber L. Rowse, Chander Raman, Kevin S. Cashman, Christine M. Sestero, Hao Li, Patrizia De Sarno, Donald J. McGuire, Binghao J. Peng
Publikováno v:
European Journal of Immunology. 44:1137-1142
Mechanisms that modulate the generation of Th17 cells are incompletely understood. We report that the activation of casein kinase 2 (CK2) by CD5 is essential for the efficient generation of Th17 cells in vitro and in vivo. In our study, the CD5-CK2 s