Výsledky vyhledávání - "Donald J. Marsh"

Akademický článek

Interacting information streams on the nephron arterial network

Autor: Donald J. Marsh, Anthony S. Wexler, Niels-Henrik Holstein-Rathlou

Publikováno v: Frontiers in Network Physiology, Vol 3 (2023)

Blood flow and glomerular filtration in the kidney are regulated by two mechanisms acting on the afferent arteriole of each nephron. The two mechanisms operate as limit cycle oscillators, each responding to a different signal. The myogenic mechanism

Externí odkaz: https://doaj.org/article/91bbbb86d64b4f87a3e96934fd816692

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Akademický článek

Phase-Specific Changes in Rate of Force Development and Muscle Morphology Throughout a Block Periodized Training Cycle in Weightlifters

Autor: Dylan G. Suarez, Satoshi Mizuguchi, William Guy Hornsby, Aaron J. Cunanan, Donald J. Marsh, Michael H. Stone

Publikováno v: Sports, Vol 7, Iss 6, p 129 (2019)

The purpose of this study was to investigate the kinetic and morphological adaptations that occur during distinct phases of a block periodized training cycle in weightlifters. Athlete monitoring data from nine experienced collegiate weightlifters was

Externí odkaz: https://doaj.org/article/f3b87f87566e4e2fb70b7d75c962419e

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Akademický článek

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Publikováno v: Journal of Lipid Research, Vol 52, Iss 6, Pp 1150-1161 (2011)

The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to be gained from such studies is of partic

Externí odkaz: https://doaj.org/article/d66b12300bbf4a1f976747589c656716

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Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

Autor: Dmitry Postnov, Donald J Marsh, Will A Cupples, Niels-Henrik Holstein-Rathlou, Olga Sosnovtseva

Publikováno v: Postnov, D, Marsh, D J, Cupples, W A, Holstein-Rathlou, N H & Sosnovtseva, O 2022, ' Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging ', eLife, vol. 11, e75284 . https://doi.org/10.7554/eLife.75284
Postnov, D, Marsh, D J, Cupples, W A, Holstein-Rathlou, N-H & Sosnovtseva, O 2022, ' Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging ', eLife, vol. 11, :e75284, pp. 1-13 . https://doi.org/10.7554/eLife.75284

Internephron interaction is fundamental for kidney function. Earlier studies have shown that nephrons signal to each other, synchronize over short distances, and potentially form large synchronized clusters. Such clusters would play an important role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa6cf12d53dbfdd5f4c5f5f75f7f175
https://pure.au.dk/portal/da/publications/synchronization-in-renal-microcirculation-unveiled-with-highresolution-blood-flow-imaging(e45a025b-df86-4cbc-b62b-e3b66839e2a8).html

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Akademický článek

Modeling of Kidney Hemodynamics: Probability-Based Topology of an Arterial Network.

Autor: Dmitry D Postnov, Donald J Marsh, Dmitry E Postnov, Thomas H Braunstein, Niels-Henrik Holstein-Rathlou, Erik A Martens, Olga Sosnovtseva

Publikováno v: PLoS Computational Biology, Vol 12, Iss 7, p e1004922 (2016)

Through regulation of the extracellular fluid volume, the kidneys provide important long-term regulation of blood pressure. At the level of the individual functional unit (the nephron), pressure and flow control involves two different mechanisms that

Externí odkaz: https://doaj.org/article/64f3e7f9180647ee95eb2932408ff70f

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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

Autor: José A. Lebrón, Kaushik Mitra, Keith Q. Tanis, Thomas G. Griffiths, Stephen Pacchione, Matthew Kuhls, Ian Knemeyer, Donald J Marsh, Wen Kang, Frank D. Sistare, Zhibin Wang, Qing Chen, Kimberly B. Bleicher, Ming Su, George M. Laws, Alexei A. Podtelezhnikov

Publikováno v: Toxicological Sciences. 177:121-139

Early risk assessment of drug-induced liver injury (DILI) potential for drug candidates remains a major challenge for pharmaceutical development. We have previously developed a set of rat liver transcriptional biomarkers in short-term toxicity studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7417a59766a499501f8970dc21422c
https://doi.org/10.1093/toxsci/kfaa094

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Blood flow synchronization in renal microcirculation - a high-resolution imaging study

Autor: Donald J. Marsh, Niels Henrik Holstein-Rathlou, Will Cupples, Olga Sosnovtseva, Dmitry D. Postnov

AimsInternephron signalling and interaction are fundamental for kidney function. Earlier studies have shown that nephrons signal to each other over short distances and adjust their activity accordingly. Micropuncture experiments revealed synchronous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eef2fc7bc9c349e08625e9c40c95b4f6
https://doi.org/10.1101/2021.10.15.464509

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Akademický článek

Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data.

Autor: Alexey R Brazhe, Donald J Marsh, Niels-Henrik Holstein-Rathlou, Olga Sosnovtseva

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e105879 (2014)

Full-field laser speckle microscopy provides real-time imaging of superficial blood flow rate. Here we apply continuous wavelet transform to time series of speckle-estimated blood flow from each pixel of the images to map synchronous patterns in inst

Externí odkaz: https://doaj.org/article/86c8a776790a4de7912c450ff9e32c6a

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Akademický článek

Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.

Autor: Hua V Lin, Andrea Frassetto, Edward J Kowalik, Andrea R Nawrocki, Mofei M Lu, Jennifer R Kosinski, James A Hubert, Daphne Szeto, Xiaorui Yao, Gail Forrest, Donald J Marsh

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35240 (2012)

Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from complex dietary carbohydrates. Butyrate and acetate were reported to protect against diet-induced obesity without causing hypo

Externí odkaz: https://doaj.org/article/f2f1e70b21f94a3baea2266fa258e484

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