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pro vyhledávání: '"Donald J. Kyle"'
Autor:
Donald J. Kyle
Publikováno v:
Current Bioactive Compounds. 19:2-2
Autor:
G T Whiteside, Terri Knappenberger, N Takai, T Itoh, Michele Hummel, Donald J. Kyle, S Hiroyama
Publikováno v:
Sleep. 43:A1-A1
Introduction Treatments for insomnia have targeted GABA, histamine, serotonin, melatonin and orexin receptors. The nociceptin/orphanin-FQ peptide (NOP) receptor is widely expressed in the nervous system. High doses of NOP agonists administered system
Autor:
Margit Solymár, Donald J. Kyle, Zsolt Szakács, András Garami, Robson Cristiano Lillo Vizin, Nelli Farkas, Wade D. Van Horn, Dan A. Chiche, Ram P. Kapil, Yury P. Shimansky, Zoltan Rumbus, Judit Hegyi, Andrej A. Romanovsky, Alexandra Csenkey, Péter Hegyi
Publikováno v:
Pharmacology & Therapeutics. 208:107474
Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body temperature (Tb) in laboratory animals and humans: most cause hyperthermia; some produce hypothermia; and yet others have no effect. TRPV1 can be activated by caps
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:43-47
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Autor:
Yasuyoshi Iso, Shintani Takuya, John J. Engel, Akira Kato, Jianming Yu, Tsuyoshi Hasegawa, Toshiyuki Asaki, Yoshitaka Yamaguchi, Naoki Tsuno, Laykea Tafesse, Chiyou Ni, Noriyuki Kurose, Kevin C. Brown, Toshiyuki Kanemasa, Gang Wu, Manjunath S. Shet, Yuka Iwamoto, Aniket Patel, Donald J. Kyle, Xiaoming Zhou
Publikováno v:
Journal of Medicinal Chemistry. 57:6781-6794
A series of novel tetrahydropyridinecarboxamide TRPV1 antagonists were prepared and evaluated in an effort to optimize properties of previously described lead compounds from piperazinecarboxamide series. The compounds were evaluated for their ability
Autor:
Jae H. Park, Donald J. Kyle, Victor I. Ilyin, Gang Wu, Laszlo L. Musza, Paul R. Blake, Kevin P. Carlin
Publikováno v:
Journal of Medicinal Chemistry. 57:6623-6631
The aqueous solution structure of protoxin II (ProTx II) indicated that the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region, similar to previously described NaSpTx III tarantula toxins
Autor:
Donald J. Kyle, Garth Whiteside, Terri Knappenberger, Sarah A. O’Keefe, Steve Harris, Michele Hummel, Lars Arendt-Nielsen, Ram P. Kapil
Publikováno v:
Arendt-Nielsen, L, Harris, S, Whiteside, G T, Hummel, M, Knappenberger, T, OʼKeefe, S, Kapil, R & Kyle, D 2016, ' A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile ', Pain, vol. 157, no. 9, pp. 2057-2067 . https://doi.org/10.1097/j.pain.0000000000000610
This experimental, translational, experimental pain, single-center, randomized, double-blind, single-dose, 3-treatment, 3-period cross-over proof-of-concept volunteer trial studied the efficacy of a novel TRPV1 antagonist (V116517) on capsaicin and U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce21895b59de33878ef578d40a199a3
https://vbn.aau.dk/da/publications/37ef066e-d43a-46cb-a4dc-13a3b2ec1e7c
https://vbn.aau.dk/da/publications/37ef066e-d43a-46cb-a4dc-13a3b2ec1e7c
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:72-81
Buprenorphine is known as a μ-opioid peptide (MOP) receptor agonist, but its antinociception is compromised by the activation of nociceptin/orphanin FQ peptide (NOP) receptors in rodents. The aim of this study was to investigate the roles of MOP and
Publikováno v:
Journal of Peptide Science. 18:442-448
Protoxin II is biologically active peptide containing the inhibitory cystine knot motif. A synthetic version of the toxin was generated with standard Fmoc solid phase peptide synthesis. If N-methylmorpholine was used as a base during synthesis of the