Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Donald J. Hnatowich"'
Autor:
Donald J. Hnatowich, Cong Peng, Xinrong Liu, Ling Chen, Yuxia Liu, Mary Rusckowski, Kayoko Nakamura, Dengfeng Cheng, Nan Xiao
Publikováno v:
Current Drug Delivery. 9:431-436
A three-component nanoparticle consisting of biotinylated Trastuzumab antiHer2 antibody, tat transferring peptide and radiolabeled antisense oligomer, linked together through streptavidin, have shown promise in the delivery to Her2+ tumor in mice fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eed20233ad4cef675e5a9d098b782dd
https://doi.org/10.2174/156720112801323035
https://doi.org/10.2174/156720112801323035
Autor:
Yi Wang, Ling Chen, Xinrong Liu, Shuping Dou, Guozheng Liu, Mary Rusckowski, Dengfeng Cheng, Donald J. Hnatowich
Publikováno v:
Nuclear Medicine Communications. 32:920-924
Aim To evaluate the targeting property in vitro and in vivo of two tumor-associated glycoprotein 72 (TAG-72) binding peptides, previously identified in this laboratory by phage selection using different elution conditions. Materials and methods The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c8d831dcf35019d4a1f2d47b7437cb
https://doi.org/10.1097/mnm.0b013e328348fc64
https://doi.org/10.1097/mnm.0b013e328348fc64
Autor:
P. Hendrik Pretorius, Shuping Dou, Minmin Liang, Nan Xiao, Guozheng Liu, Xinrong Liu, Donald J. Hnatowich, Ling Chen, Mary Rusckowski, Yuxia Liu, Dengfeng Cheng
Publikováno v:
Nuclear Medicine and Biology. 38:843-848
Introduction Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bec48cb8d0c0d58644d186aeecb304d
https://doi.org/10.1016/j.nucmedbio.2011.02.004
https://doi.org/10.1016/j.nucmedbio.2011.02.004
Autor:
Guozheng Liu, Mary Rusckowski, Xiangji Chen, Ling Chen, Shuping Dou, Xinrong Liu, Donald J. Hnatowich
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 25:757-762
Clearing agents are often used in pretargeting despite the potential for decreased tumor accumulation of the effector. However, according to the authors' semiempirical model, a clearing agent should not necessarily decrease tumor accumulation. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676dad05d8c7314b677607f709e1098d
https://doi.org/10.1089/cbr.2010.0800
https://doi.org/10.1089/cbr.2010.0800
Publikováno v:
Applied Radiation and Isotopes. 68:1709-1714
An ability to quantitate the beta cell mass by noninvasive nuclear imaging will be very useful in the prevention, diagnosis, and treatment of diabetes. However, to be successful, radioactivity from the pancreas must not be obscured by the background
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2860f842c4acd3801fb2578471cccf0d
https://doi.org/10.1016/j.apradiso.2010.03.002
https://doi.org/10.1016/j.apradiso.2010.03.002
Autor:
Dengfeng Cheng, P. Hendrik Pretorius, Yi Wang, Minmin Liang, Mary Rusckowski, Donald J. Hnatowich, Xinrong Liu
Publikováno v:
Bioconjugate Chemistry. 21:1565-1570
Our objective was to compare the performance of a micro-single photon emission computed tomography (micro-SPECT) with that of a micro-positron emission tomography (microPET) in a Her2+ tumored mice using an anti-Her2 nanoparticle radiolabeled with (9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed46a5f4397ab4889d30fdc8741b01e
https://doi.org/10.1021/bc1001467
https://doi.org/10.1021/bc1001467
Publikováno v:
Molecular Pharmaceutics. 7:1118-1124
Pretargeting with bivalent effectors capable of bridging antitumor antibodies (affinity enhancement pretargeting) has been reported to provide superior results by affinity enhancement. Phosphorodiamidate morpholinos (MORFs) and other DNA analogues us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7314178cd52fd39315ea68d0e10b8c3e
https://doi.org/10.1021/mp9002909
https://doi.org/10.1021/mp9002909
Autor:
Xinrong Liu, Ling Chen, Dengfeng Cheng, Yi Wang, Mary Rusckowski, Donald J. Hnatowich, Kayoko Nakamura, Minmin Liang, Nan Xiao
Publikováno v:
Journal of Biomedical Nanotechnology. 6:153-157
We reported recently that a three-component nanoparticle, consisting of a targeting antibody, a transfecting peptide and an 111In-antiRIalpha MORF antisense oligomer, provided Auger electron-mediated, antisense-mediated, cytotoxicity of cells in cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a180f904a6787a6f84806099e7e3947
https://doi.org/10.1166/jbn.2010.1111
https://doi.org/10.1166/jbn.2010.1111
Publikováno v:
European Journal of Cancer. 45:3098-3103
Our previous studies have indicated that the optimal dosage ratio of pretargeting antibody to effector is proportional to their maximum percent tumour accumulations (MPTAs). This study quantitatively describes how both MPTAs and their ratio change wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fce0a9eeaf10151dff7d513c709ca23
https://doi.org/10.1016/j.ejca.2009.09.007
https://doi.org/10.1016/j.ejca.2009.09.007
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 36:1977-1986
Trastuzumab (Herceptin™) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb06a4c6ce380f0eeefe45e12940fea7
https://doi.org/10.1007/s00259-009-1201-2
https://doi.org/10.1007/s00259-009-1201-2