Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Donald J. Gruol"'
Publikováno v:
Molecular Pharmacology. 62:1238-1248
P-glycoproteins (P-gp) cause the efflux of a wide variety of unrelated hydrophobic compounds out of cells. However, the locations of the sites at which different classes of molecules initially interact with the protein are not well defined. A unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ec2f98fa40efbf074ae8b75096ce6c
https://doi.org/10.1124/mol.62.5.1238
https://doi.org/10.1124/mol.62.5.1238
Autor:
Donald J. Gruol, Quang D. Vo
Publikováno v:
Journal of Biological Chemistry. 274:20318-20327
P-glycoproteins transport a wide variety of hydrophobic compounds out of cells. While the diversity of transported molecules suggests a mechanism involving broad specificity, there is evidence of significant discrimination within given classes of mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94afc9b7c63ecf90460e1e2a6f559c8b
https://doi.org/10.1074/jbc.274.29.20318
https://doi.org/10.1074/jbc.274.29.20318
Autor:
Kristal A. Wolfe, Donald J. Gruol
Publikováno v:
Biochemistry. 29:7958-7966
RU 486 is a synthetic steroid that binds avidly to glucocorticoid receptors without promoting their transformation into activated transcription factors. A significant part of this behavior has been shown to be due to a failure of the RU 486 bound rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa784a289372b02d807d0898ec07878
https://doi.org/10.1021/bi00486a026
https://doi.org/10.1021/bi00486a026
Autor:
Tracy A, Brooks, Daniel R, Kennedy, Donald J, Gruol, Iwao, Ojima, Maria R, Baer, Ralph J, Bernacki
Publikováno v:
Anticancer research. 24(2A)
Clinical drug resistance is frequently associated with overexpression of the multidrug resistance (MDR) proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1) and breast cancer resistance protein (BCRP). Taxanes are substrates for Pgp an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::211853668c0f0145a1368901895a52db
https://pubmed.ncbi.nlm.nih.gov/15152938
https://pubmed.ncbi.nlm.nih.gov/15152938
Publikováno v:
Molecular pharmacology. 60(1)
Murine thymoma cell lines expressing mutated forms of the mdr1b P-glycoprotein were isolated using a novel taxane-based P-glycoprotein inhibitor tRA-96023 (SB-RA-31012). The selection strategy required resistance to a combination of tRA-96023 and col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5b26097f785c43380d1813d798e852
https://pubmed.ncbi.nlm.nih.gov/11408605
https://pubmed.ncbi.nlm.nih.gov/11408605
Publikováno v:
Biochemical pharmacology. 58(7)
There are two mouse P-glycoproteins that convey multidrug resistance, mdr1 (mdr1b) and mdr3 (mdr1a), by serving as drug efflux transporters. These proteins each exhibit tissue-specific expression. There is relatively high expression of the mdr1 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dce1969d57ee98d1e8cd3b7ce136407
https://pubmed.ncbi.nlm.nih.gov/10484077
https://pubmed.ncbi.nlm.nih.gov/10484077
Autor:
Suzanne Bourgeois, Donald J. Gruol
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 72(11-12)
Glucocorticoid hormones cause apoptosis in the murine T-lymphoma cell line WEHI-7. Glucocorticoid receptors in these cells are cytoplasmic proteins that translocate to the nucleus upon binding hormone. Thus, regulation of cytoplasmic glucocorticoid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a399d6e787f20f96b25a4d1f940a1bc6
https://pubmed.ncbi.nlm.nih.gov/7654329
https://pubmed.ncbi.nlm.nih.gov/7654329
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 7(7)
A variant, MS23, of murine thymoma W7 cells, previously selected for its resistance to low concentrations of dexamethasone, is cross-resistant to unrelated drugs such as puromycin and colchicine. We report here that transcription of the mouse mdr1 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7499087410f8dbc9cb830cde5b198c8
https://pubmed.ncbi.nlm.nih.gov/8105374
https://pubmed.ncbi.nlm.nih.gov/8105374
Autor:
Donald J. Gruol, Joachim Altschmied
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 7(1)
Glucocorticoids induce a programmed cell death in immature murine T cells through a process that has been named apoptosis. Cyclic AMP-dependent protein kinase (PKA) activity contributes to this response but acts through an undefined mechanism. Steroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a068de3d13827d5ff248abd9b42a2f
https://pubmed.ncbi.nlm.nih.gov/8383286
https://pubmed.ncbi.nlm.nih.gov/8383286
Publikováno v:
Journal of Biological Chemistry. 261:4909-4914
Murine lymphoma cell lines such as WEHI-7 exhibit a cytolytic response to both cAMP and glucocorticoids. We have exploited this behavior to ask if cyclic AMP-dependent protein kinase plays a role in regulating glucocorticoid receptor function. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd05fbd5b7a76f681849dd0e091bd95f
https://doi.org/10.1016/s0021-9258(19)89191-3
https://doi.org/10.1016/s0021-9258(19)89191-3