Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection

Autor: Sofia Sintoris, Justyna M. Binkowska, Jonathan L. Gillan, Roy P. Zuurbier, Jonathan Twynam-Perkins, Maartje Kristensen, Lauren Melrose, Paula Lusaretta Parga, Alicia Ruiz Rodriguez, Mei Ling Chu, Sara R. van Boeckel, Joanne G. Wildenbeest, Dawn M. E. Bowdish, Andrew J. Currie, Ryan S. Thwaites, Jurgen Schwarze, Marlies A. van Houten, James P. Boardman, Steve Cunningham, Debby Bogaert, Donald J. Davidson

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract Respiratory syncytial virus is the major cause of acute lower respiratory tract infections in young children, causing extensive mortality and morbidity globally, with limited therapeutic or preventative options. Cathelicidins are innate immu

Externí odkaz: https://doaj.org/article/7a315c29b5364d6da9023a1485e4aecf

The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

Autor: Danielle Minns, Katie J. Smith, Virginia Alessandrini, Gareth Hardisty, Lauren Melrose, Lucy Jackson-Jones, Andrew S. MacDonald, Donald J. Davidson, Emily Gwyer Findlay

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Neutrophils secrete numerous immune effector molecules including cathelicidin which is associated with antimicrobial properties. Here the authors implicate neutrophil derived cathelicidin in modulation of CD4 T cell homoeostasis and the promotion of

Externí odkaz: https://doaj.org/article/575b66e7e8b04cad96678a2c55c7e867

The Dichotomous Responses Driven by β-Defensins

Autor: Jennifer R. Shelley, Donald J. Davidson, Julia R. Dorin

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Defensins are short, rapidly evolving, cationic antimicrobial host defence peptides with a repertoire of functions, still incompletely realised, that extends beyond direct microbial killing. They are released or secreted at epithelial surfaces, and i

Externí odkaz: https://doaj.org/article/c46953f7446b4265bf20c50baccf682a

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy

Autor: Emily Gwyer Findlay, Andrew J. Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J. McHugh, Marta Canel, Mohini Gray, Simon W.F. Milling, John D.M. Campbell, John Savill, Alan Serrels, Donald J. Davidson

Publikováno v: OncoImmunology, Vol 8, Iss 8 (2019)

Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research. Despite progress and approval of clinical approaches, significant enhancement

Externí odkaz: https://doaj.org/article/8c619a0ba3fa49a6a60740bf5be1c638

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages

Autor: Jonathan L. Gillan, Mithil Chokshi, Gareth R. Hardisty, Sara Clohisey Hendry, Daniel Prasca-Chamorro, Nicola J. Robinson, Benjamin Lasota, Richard Clark, Lee Murphy, Moira K. B. Whyte, J. Kenneth Baillie, Donald J. Davidson, Gang Bao, Robert D. Gray

Publikováno v: Gillan, J L, Chokshi, M, Hardisty, G R, Clohisey Hendry, S, Prasca-Chamorro, D, Robinson, N J, Lasota, B, Clark, R, Murphy, L, Whyte, M K B, Baillie, J K, Davidson, D J, Bao, G & Gray, R D 2023, ' CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages ', Science Advances, vol. 9, no. 21, eadg5128, pp. 1-17 . https://doi.org/10.1126/sciadv.adg5128

An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d6f49036f9327fdf6f94531d99523
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf