Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Donald J. Cook"'
Autor:
Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Naomi Laing, Vibha Oza, David Whitston, Victor Kamhi, Jamal Carlos Saeh, Lillian Castriotta, Li Sha, Troy Patterson, Christopher Huntington, Danyang Li, Haiyun Wang, Charles A. Omer, Alexander Hird, Melissa Vasbinder, Donald J. Cook, Michael T. Rooney, Galina Repik, Maureen Hattersley, Ammar Adam
Publikováno v:
Journal of Medicinal Chemistry. 56:9897-9919
A series of dimeric compounds based on the AVPI motif of Smac were designed and prepared as antagonists of the inhibitor of apoptosis proteins (IAPs). Optimization of cellular potency, physical properties, and pharmacokinetic parameters led to the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079e8f0834b2e3a19409696494674136
https://doi.org/10.1021/jm401075x
https://doi.org/10.1021/jm401075x
Autor:
Carrie L. Balliet, Srinivasu Poondru, Charles A. Omer, Davies Audrey, Thomas Gero, Scott David, Donald J. Cook, Maria-Elena Theoclitou, Boris Tyurin, Michael Zinda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:697-700
3-amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb36ec38fcfe80e9016030ca0f18b3e
https://doi.org/10.1016/j.bmcl.2008.12.046
https://doi.org/10.1016/j.bmcl.2008.12.046
Autor:
Lisa Drew, Les A. Dakin, Boris Tyurin, Kirsten Bell, Maureen Hattersley, Scott David, Xiaolan Zheng, Cheryl Campbell, Thomas Gero, Donald J. Cook, Charles A. Omer, David J. Del Valle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:701-705
The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e3beb884810cfa8a555c097e777bc3
https://doi.org/10.1016/j.bmcl.2008.12.044
https://doi.org/10.1016/j.bmcl.2008.12.044
Autor:
Charles A. Omer, Tracy L. Deegan, Minwei Ye, Les A. Dakin, Paul Lyne, Maureen Hattersley, Donald J. Cook, Xiaolan Zheng, Stephanos Ioannidis, Brian Aquila, Geraldine Bebernitz, Scott David
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4794-4797
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840dc35ec4d62a9f6566171915cb9740
https://doi.org/10.1016/j.bmcl.2008.07.093
https://doi.org/10.1016/j.bmcl.2008.07.093
Publikováno v:
2013 25th International Symposium on Power Semiconductor Devices & IC's (ISPSD).
In this paper, we discuss the fundamental design tradeoff among specific on-resistance (Ron, sp), gate charge (Cgg), quasi-saturation, and reliability characteristics for an integrated high voltage LDMOS. A novel patterned gate design is proposed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d63a856c21cbdab2f4eff22882bb93
https://doi.org/10.1109/ispsd.2013.6694446
https://doi.org/10.1109/ispsd.2013.6694446
Autor:
Rick Phelps, Theodode Letavic, Natalie B. Feilchenfeld, Donald J. Cook, Michael J. Zierak, Santosh Sharma, Yun Shi
Publikováno v:
2013 25th International Symposium on Power Semiconductor Devices & IC's (ISPSD).
This paper presents complimentary 85V-rated LDMOS devices integrated in a 180nm power management technology platform. The devices are fabricated using a design technique which utilizes tapered dielectric regions in combination with patterned floating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de0de10eba9b1521b7501d9f36fd0d8
https://doi.org/10.1109/ispsd.2013.6694423
https://doi.org/10.1109/ispsd.2013.6694423
Autor:
John J. Ellis-Monaghan, Natalie B. Feilchenfeld, James S. Dunn, Yun Shi, Rick Phelps, Ted Letavic, Donald J. Cook, Crystal M. Hedges, Santosh Sharma
Publikováno v:
2012 24th International Symposium on Power Semiconductor Devices and ICs.
A novel JFET redesign of a laterally scaled P-LDMOS device is presented. The P-LDMOS device has excellent Rsp as it is scaled from 90V to 170V operation. This P-LDMOS design is modified to produce a 100V PJFET with good turn-off characteristics and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03861133e67c3e00aac7c5234ba56c88
https://doi.org/10.1109/ispsd.2012.6229040
https://doi.org/10.1109/ispsd.2012.6229040
Autor:
Rick Phelps, Donald J. Cook, Helmut Nauschnig, Santosh Sharma, Georg Roerher, Alain Loiseau, Rainer Minixhofer, Theodore J. Letavic, Yun Shi, John-Ellis Monaghan, James S. Dunn, Natalie B. Feilchenfeld, Christopher Lamothe
Publikováno v:
2012 24th International Symposium on Power Semiconductor Devices and ICs.
This paper presents a 20V-rated planar dual gate oxide NLDMOS power device structure fabricated in a 180nm power management technology. The performance of the planar dual gate device structure is compared to a conventional STI-based device and it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0e20dcf055204e8d650f75d8097771
https://doi.org/10.1109/ispsd.2012.6229107
https://doi.org/10.1109/ispsd.2012.6229107
Autor:
Dominique Custeau, Srinivasu Poondru, Qing Ye, Minhui Shen, Donald J. Cook, Jay Ezhuthachan, Michael Howard Block, Lee John W, Paul Lyne, Scott David, Allan Wu, Mei Su, Lisa Drew, Timothy Pontz, Les A. Dakin, Stephanos Ioannidis, Tracy L. Deegan, Scott Cowen, Brian Aquila, Xiaolan Zheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
A series of amidoheteroaryl compounds were designed and synthesized as inhibitors of B-Raf kinase. Several compounds from the series show excellent potency in biochemical, phenotypic and mode of action cellular assays. Potent examples from the series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96353995ce932346b9bc19c7be48312
https://pubmed.ncbi.nlm.nih.gov/19097792
https://pubmed.ncbi.nlm.nih.gov/19097792
Autor:
Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Daniel John Russell, Bin Yang, Dave Witson, Jamal Carlos Saeh, Maureen Hattersley, Paula Lewis, Michael T. Rooney, Charles A. Omer, Galina Repik, Victor Kamhi, Li Sha, Danyang Li, Haiyun Wang, John Lee, Troy Patterson, Naomi Laing, Melissa Vasbinder, Donald J. Cook, Andrew D. Ferguson, Vibha Oza, Alexander Hird
Publikováno v:
Molecular Cancer Therapeutics. 12:B100-B100
Both monomeric and dimeric SMAC (Second Mitochondria-derived Activator of Caspaces) mimetics acting as IAP (Inhibitor of apoptosis proteins) anatgonists have been reported in the clinic as well as extensively in the literature (1). The first four ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4668cffad077f369ffdc873b69834302
https://doi.org/10.1158/1535-7163.targ-13-b100
https://doi.org/10.1158/1535-7163.targ-13-b100