Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro

Autor: Kris V. Kowdley, Donald J. Messner, Todd Robinson

Publikováno v: Nutrition and Cancer. 69:481-489

Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cb86aa5d617c2dd851efd435764628
https://doi.org/10.1080/01635581.2017.1274407

Contributors

Autor: Yasutada Akiba, Denise Al Alam, Rana Al-Sadi, Qasim Aziz, Eric J. Battaglioli, Adil E. Bharucha, Richard S. Blumberg, Natacha Bohin, Joel C. Bornstein, Stuart M. Brierley, Simon J.H. Brookes, Joel Castro, Eugene B. Chang, Benoit Chassaing, Mary Cheung, Matthew A. Ciorba, Sheila E. Crowe, Michael Czerwinski, Soula Danopoulos, Soumita Das, Peter J. Dempsey, Gerco den Hartog, Hideki Enomoto, Andelain Erickson, Peter B. Ernst, Adam D. Farmer, Jaime P.P. Foong, Mark R. Frey, Andrew T. Gewirtz, Fayez K. Ghishan, Fiona M. Gribble, Luke Grundy, Marlene M. Hao, Andrea M. Harrington, Grant W. Hennig, Hongzhen Hu, Jan D. Huizinga, Shankar S. Iyer, Izumi Kaji, Purna C. Kashyap, Jonathan D. Kaunitz, Jennifer S. Labus, Brigitte Lavoie, Cambrian Y. Liu, Thomas Y. Ma, Xiaoya Ma, Gary M. Mawe, Juanita L. Merchant, Jeannette S. Messer, Larry Miller, Bruce D. Naliboff, Mark T. Nelson, Donald F. Newgreen, Prashant Nighot, Monica Passi, D. Brent Polk, Maria J. Pozo, Frank Reimann, Geoffrey P. Roberts, Bani C. Roland, James K. Ruffle, Hyder Said, Linda C. Samuelson, Michael A. Schumacher, Yatrik M. Shah, Terez Shea-Donohue, Noah F. Shroyer, Jason R. Spence, Nick J. Spencer, Stephanie N. Spohn, Lincon A. Stamp, William F. Stenson, Miyako Takaki, Kirsten Tillisch, Toshihiro Uesaka, Gijs R. van den Brink, Willemijn A. van Dop, Anil Vegesna, Jakob von Moltke, Arnold Wald, B. Florien Westendorp, Mathew Whitson, Jackie D. Wood, Hua Xu, Vincent W. Yang, Heather M. Young, Vincent B. Young, Nada A. Abumrad, Waddah A. Alrefai, Rana Ammoury, Gregory J. Anderson, Shinji Asano, Giorgos Bamias, Yangzom D. Bhutia, Niviann M. Blondet, Patrick Borel, Vincenza Cifarelli, James F. Collins, Robert J. Cousins, Nicholas O. Davidson, Paul A. Dawson, Guillaume de Lartigue, Charles Desmarchelier, Pradeep K. Dudeja, Shireen R.L. Flores, Vadivel Ganapathy, Chiara Ghezzi, Ravinder K. Gill, Fred S. Gorelick, Matthew B. Grisham, Earl H. Harrison, Gail A. Hecht, Dawn A. Israel, James D. Jamieson, Bryson W. Katona, Pawel R. Kiela, Rachel E. Kopec, Kris V. Kowdley, Nicholas F. LaRusso, Seong M. Lee, Rodger A. Liddle, Juan P. Liuzzi, Donald D.F. Loo, John P. Lynch, Anatoliy I. Masyuk, Tatyana V. Masyuk, Donald J. Messner, Mark B. Meyer, Karen F. Murray, Ebba Nexo, Curtis T. Okamoto, Bernardo Ortega, Stephen Pandol, Richard M. Peek, J. Wesley Pike, Shubha Priyamvada, Gordon B. Proctor, Vazhaikkurichi M. Rajendran, Helen E. Raybould, Jesus Rivera-Nieves, Hamid M. Said, Hideki Sakai, Seema Saksena, Monica Sala-Rabanal, Jörg-Dieter Schulzke, Ursula E. Seidler, Abeer K. Shaalan, Irshad A. Sheikh, Jay R. Thiagarajah, Alan S. Verkman, Xiaoyu Wang, Paul A. Welling, Allan W. Wolkoff, Ernest M. Wright

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51874f576fda423b8a309cb9f57d8157
https://doi.org/10.1016/b978-0-12-809954-4.09991-6

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

Autor: Mary Beauchamp, Heather M. Klintworth, Vicki Morgan-Stevenson, Barjinderjit K. Dhillon, Kris V. Kowdley, James E. Nelson, Priya Handa, Clinton Elfers, Christian L. Roth, Donald J. Messner, Bryan D. Maliken, Matthew M. Yeh

Publikováno v: Hepatology. 60:133-145

Obesity and adiponectin depletion have been associated with the occurrence of nonalcoholic fatty liver disease (NAFLD). The goal of this study was to identify the relationship between weight gain, adiponectin signaling, and development of nonalcoholi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d03fb9db45798b8429ba850682018043
https://doi.org/10.1002/hep.26946

Silybin Treatment is Associated With Reduction in Serum Ferritin in Patients With Chronic Hepatitis C

Autor: Jose Berger, Leanna J. Standish, Julie M. Bares, James E. Nelson, Donald J. Messner, Sandra Schildt, Kris V. Kowdley

Publikováno v: Journal of Clinical Gastroenterology. 42:937-944

The goal of this study was to examine the effect of a standardized silybin and soy phosphatidylcholine complex (IdB 1016) on serum markers of iron status.Milk thistle and its components are widely used as an alternative therapy for liver disease beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22d79ee60589ad4d18e5161a90ef0ed
https://doi.org/10.1097/mcg.0b013e31815cff36

A Targeted Library of Small-Molecule, Tyrosine, and Dual-Specificity Phosphatase Inhibitors Derived from a Rational Core Design and Random Side Chain Variation

Autor: Alton L Boynton, John S. Lazo, Robert L. Rice, Donald J Messner, James M. Rusnak, Peter Wipf, Fumiaki Yokokawa, Shiho Yokokawa

Publikováno v: Biochemistry. 36:15965-15974

Tyrosine phosphatases (PTPases) dephosphorylate phosphotyrosines while dual-specificity phosphatases (DSPases) dephosphorylate contiguous and semicontiguous phosphothreonine and phosphotyrosine on cyclin dependent kinases and mitogen-activated protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb4eb00dd11eac069519571663aebf2
https://doi.org/10.1021/bi971338h