Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Donald J, Zack"'
Autor:
Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald J. Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou, Jiang Qian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cell (RGC) survival following optic
Externí odkaz:
https://doaj.org/article/b1cda4bead69404db2565077129f3d56
Autor:
Michael L. Risner, Marcio Ribeiro, Nolan R. McGrady, Bhanu S. Kagitapalli, Xitiz Chamling, Donald J. Zack, David J. Calkins
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and extracellular vesicles (
Externí odkaz:
https://doaj.org/article/ba8cbac6e19c414cbb766f5391c5ec38
Autor:
Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-46 (2023)
Abstract Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system’s limited regenerative capacity. RGC repopulation is a promising therapeutic approac
Externí odkaz:
https://doaj.org/article/0496dd9029ef4175a2c853ac2f6e61b3
Autor:
Thomas V. Johnson, MD, PhD, Petr Baranov, MD, PhD, Adriana Di Polo, PhD, Brad Fortune, OD, PhD, Kimberly K. Gokoffski, MD, PhD, Jeffrey L. Goldberg, MD, PhD, William Guido, PhD, Alex L. Kolodkin, PhD, Carol A. Mason, PhD, Yvonne Ou, MD, Thomas A. Reh, PhD, Ahmara G. Ross, MD, PhD, Brian C. Samuels, MD, PhD, Donald J. Zack, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 4, Pp 100390- (2023)
Purpose: The Retinal Ganglion Cell (RGC) Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) consortium was founded in 2021 to help address the numerous scientific and clinical obstacles that impede development of vision-
Externí odkaz:
https://doaj.org/article/97c541baf29f4361882762299e8ef428
Autor:
Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G. McGrath, Weixiang Fang, Chaoran Chen, Felipe Takaesu, Xiaoli Chang, Yukan Duan, Dinesh Kumar, Calvin Chang, Hai-Quan Mao, Guoqing Sheng, James C. Dodge, Hongkai Ji, Stephen Madden, Donald J. Zack, Xitiz Chamling
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106156- (2023)
Summary: Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for CNS demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination-promoting compoun
Externí odkaz:
https://doaj.org/article/84e544c0e3584673bb73309824fd116b
Autor:
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of powe
Externí odkaz:
https://doaj.org/article/aebc0f0cd878418ebed9205a612b1932
Autor:
Ping-Wu Zhang, Steven H. Zhang, Wei-Feng Li, Casey J. Keuthan, Shuaizhang Li, Felipe Takaesu, Cynthia A. Berlinicke, Jun Wan, Jing Sun, Donald J. Zack
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104225- (2022)
Summary: Background: Though case fatality rate (CFR) is widely used to reflect COVID-19 fatality risk, its use is limited by large temporal and spatial variation. Hospital mortality rate (HMR) is also used to assess the severity of COVID-19, but HMR
Externí odkaz:
https://doaj.org/article/371b2d7393c74a1d9f7ffd0914b709cb
Autor:
Casey N. Barber, Hana L. Goldschmidt, Brendan Lilley, Alexei M. Bygrave, Richard C. Johnson, Richard L. Huganir, Donald J. Zack, Daniel M. Raben
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100247- (2022)
Phosphatidic acid is a key signaling molecule heavily implicated in exocytosis due to its protein-binding partners and propensity to induce negative membrane curvature. One phosphatidic acid-producing enzyme, phospholipase D (PLD), has also been impl
Externí odkaz:
https://doaj.org/article/ff4db0915c4049ca95f94efafaacc188
Autor:
Srinivasa R. Sripathi, Ming-Wen Hu, Ravi Chakra Turaga, Rebekah Mikeasky, Ganesh Satyanarayana, Jie Cheng, Yukan Duan, Julien Maruotti, Karl J. Wahlin, Cynthia A. Berlinicke, Jiang Qian, Noriko Esumi, Donald J. Zack
Publikováno v:
Cells, Vol 12, Iss 8, p 1155 (2023)
Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic development, malignant transformation, and tumor progression, has also been implicated in a variety of retinal diseases, including proliferative vitreoretinopathy
Externí odkaz:
https://doaj.org/article/d5409e6c65bb44babe7141eeb0848c9b
Autor:
Xitiz Chamling, Alyssa Kallman, Weixiang Fang, Cynthia A. Berlinicke, Joseph L. Mertz, Prajwal Devkota, Itzy E. Morales Pantoja, Matthew D. Smith, Zhicheng Ji, Calvin Chang, Aniruddha Kaushik, Liben Chen, Katharine A. Whartenby, Peter A. Calabresi, Hai-Quan Mao, Hongkai Ji, Tza-Huei Wang, Donald J. Zack
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Brain myelinating oligodendrocytes are rare and difficult to isolate, which has limited data on their development. Here the authors develop a reporter for scalable purification of human pluripotent stem cell derived oligodendrocyte lineage cells, and
Externí odkaz:
https://doaj.org/article/e96ddf8af967458184f40a76c755772f