Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Donald Heng Rong Ting"'
Publikováno v:
Expert Opinion on Drug Discovery. 16:47-58
From both a public health and economic perspective, vaccination is arguably the most effective approach to combat endemic and pandemic infectious diseases. Dengue affects more than 100 countries in the tropical and subtropical world, with 100-400 mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa4e39f92bf3b9a9308a9aea678a3f8
https://doi.org/10.1080/17460441.2020.1811675
https://doi.org/10.1080/17460441.2020.1811675
Autor:
Edem, Gavor, Yeu Khai, Choong, Nikhil Kumar, Tulsian, Digant, Nayak, Fakhriedzwan, Idris, Hariharan, Sivaraman, Donald Heng Rong, Ting, Alonso, Sylvie, Yu Keung, Mok, R Manjunatha, Kini, J, Sivaraman
Publikováno v:
Life Science Alliance
Using high-resolution structure, we have characterized the substrate specificity of Aedes aegypti procarboxypeptidase B1 and provided mechanistic insights into the binding and inhibition of DENV
Metallocarboxypeptidases play critical roles in th
Metallocarboxypeptidases play critical roles in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46c8150c1cb0a96cbc76714565d7851e
https://pubmed.ncbi.nlm.nih.gov/34750241
https://pubmed.ncbi.nlm.nih.gov/34750241
Autor:
Chanditha Hapuarachchi, Eunice Tze Xin Tan, Yukei Oo, Sylvie Alonso, Lee Ching Ng, Janice Zuo Hui Chia, Fakhriedzwan Idris, Clement Peng Hee Boey, Pei Xuan Lee, Li Ching Ong, Donald Heng Rong Ting, Yen Leong Chua
Publikováno v:
The Journal of Experimental Medicine
Lee et al. show that circulating NS1 protein does not contribute to dengue pathogenesis in mice infected with highly virulent DENV2 strains. Instead, structural prME region is found to play a critical role in the in vivo fitness and virulence of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab02235485ae2d146ecf214c817dc2c
http://europepmc.org/articles/PMC7478733
http://europepmc.org/articles/PMC7478733
Autor:
Donald Heng Rong Ting, Eunice Tze Xin Tan, Clement Peng Hee Boey, Janice Zuo Hui Chia, Pei Xuan Lee, Li Ching Ong, Lee Ching Ng, Chanditha Hapuarachchi, Yen Leong Chua, Sylvie Alonso
Dengue is a major public health concern in the tropical and sub-tropical world with no effective treatment. The controversial live attenuated virus vaccine Dengvaxia has boosted the pursuit of sub-unit vaccine approaches, and the non-structural prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03859e7056ffe7240628948c8750cb4
Autor:
Donald Heng Rong Ting, Alonso Sylvie, Digant Nayak, Yu-Keung Mok, Fakhriedzwan Idris, Yeu Khai Choong, Edem Gavor, Nikhil Kumar Tulsian, Hariharan Sivaraman, R. Manjunatha Kini, J. Sivaraman
Publikováno v:
Life Science Alliance. 5:e202101211
Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report the crystal structure of Aedes aegypti procarboxypeptidase B1 (PCPBAe1), characterized its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0a479660352b79010ccc0d8bacd9ab0
https://doi.org/10.26508/lsa.202101211
https://doi.org/10.26508/lsa.202101211
Publikováno v:
Expert review of anti-infective therapy. 15(2)
Dengue is a prevalent disease in tropical and subtropical countries with an estimated 400 million people infected annually. While significant advancement has been made in the chase for an effective dengue vaccine, the recently licensed Sanofi vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae90d0b58ad853d866dac208c55fe97
https://pubmed.ncbi.nlm.nih.gov/27796143
https://pubmed.ncbi.nlm.nih.gov/27796143