Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Donald H. Singer"'
Publikováno v:
The American Journal of Cardiology. 105:1181-1185
The population's aging underscores the need to understand the process and define the physiologic markers predictive of healthy longevity. The findings that aging is associated with a progressive decrease in heart rate variability (HRV), an index of a
Autor:
Yusaku Sakakibara, Hongjun Jia, T. Furukawa, Shin Ichi Koumi, J. Andrew Wasserstrom, Carl L. Backer, Donald H. Singer, C. E. Arentzen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 27:831-846
T. Furukawa, S.-I. Koumi, Y. Sakakibara, D. H. Singer, H. Jia, C. E. Arentzen, C. E. Backer and J. W. Wasserstrom. An Analysis of Lidocaine Block of Sodium Current in Isolated Human Atrial and Ventricular Myocytes. Journal of Molecular and Cellular C
Publikováno v:
Japanese Journal of Electrocardiology. 15:202-210
単一吸引電極法を用いて, ヒト心房筋細胞のCa電流を記録した.L型のCa電流は-30mVで活性化され, 0mVで最大振幅の0.92±0.32nAを呈し, その電流密度は7.3±2.6μA/cm2と推定された (n=13) .本電流はCa電
Autor:
Hongjun Jia, C. E. Arentzen, J. A. Wasserstrom, Y. Sakakibara, R S Hartz, T. Furukawa, Donald H. Singer
Publikováno v:
Circulation Research. 71:535-546
Patch-clamp recording techniques have permitted measurement of the fast Na+ current (INa) in isolated cardiac cells from a number of species in recent years. However, there is still only very little information concerning human cardiac INa. The purpo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 259:H488-H496
Na-K pump current (Ipump) is a function of the intracellular Na+ concentration [( Na+]i). We examined the quantitative relationship between Ipump and [Na+]i in isolated guinea pig ventricular myocytes under steady-state conditions. [Na+]i was control
Autor:
John W. Schaad, Dan J. Fintel, Diederik C.A. Van Hoogenhuyze, Donald H. Singer, Jerry S. Weiss, Gary J. Martin
Publikováno v:
Journal of Electrocardiology. 22:204-208
Publikováno v:
Circulation Research. 66:191-201
Cells in many specimens of human ventricle can exhibit either of two stable levels of diastolic potential (DP) when exposed to 4 mM K+ in vitro (i.e., -78 +/- 4 mV or -45 +/- 5 mV, mean +/- SEM). In this report we show that the DP of some partially d
Autor:
Michael Burch, Keld E. Sørensen, Donald H. Singer, Art Ationu, Nicholas D. Carter, B Whitehead
Publikováno v:
Cardiovascular research. 27(12)
Objective: The aim was to examine ventricular brain natriuretic peptide (B-type natriuretic peptide, BNP) gene expression and to determine its relationship with ventricular BNP and circulating BNP levels in paediatric cardiac transplant recipients, o
Autor:
Carl L. Backer, J. A. Wasserstrom, Hongjun Jia, T. Furukawa, C. E. Arentzen, Y. Sakakibara, Donald H. Singer
Publikováno v:
The American journal of physiology. 265(4 Pt 2)
Although fast sodium current (INa) plays a major role in the generation and conduction of the cardiac impulse, the electrophysiological characteristics of INa in isolated human ventricular myocytes have not yet been fully described. We characterized
Publikováno v:
Cardiovascular research. 27(2)
Objective: The aim was to examine the ventricular expression of brain natriuretic peptide (BNP) in the transplanted human heart. Methods: Serial right ventricular biopsies (n=68) and plasma samples (n=68) were obtained for measurement of BNP and atri