Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Donald H. Rubin"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 9, p e1005074 (2016)
Viruses require host cellular factors for successful replication. A comprehensive systems-level investigation of the virus-host interactome is critical for understanding the roles of host factors with the end goal of discovering new druggable antivir
Externí odkaz:
https://doaj.org/article/435ce6bf9e8b4777a5767ce67230e807
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46866 (2012)
Evidence from multiple studies suggests that Clostridium perfringens ε-toxin is a pore-forming toxin, assembling into oligomeric complexes in the plasma membrane of sensitive cells. In a previous study, we used gene-trap mutagenesis to identify mamm
Externí odkaz:
https://doaj.org/article/23dde0b66e1847c3a2af948d261983b7
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17787 (2011)
The Clostridium perfringens ε-toxin is an extremely potent toxin associated with lethal toxemias in domesticated ruminants and may be toxic to humans. Intoxication results in fluid accumulation in various tissues, most notably in the brain and kidne
Externí odkaz:
https://doaj.org/article/2a0b01af86044e2baed7db549b13d281
Publikováno v:
Open Forum Infectious Diseases
Toxoplasma gondii is a common parasite that infects warm-blooded animals, including humans, and is a foodborne pathogen. We report a case of acute toxoplasmosis in a 76-year-old man after ingestion of the undercooked heart of a white-tailed deer (Odo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e4ccdc71bfc21e71c139524aa5919b
http://europepmc.org/articles/PMC6324552
http://europepmc.org/articles/PMC6324552
Autor:
D. Borden Lacy, Donald H. Rubin, Ramyavardhanee Chandrasekaran, Michelle E. LaFrance, Melissa A. Farrow, Jinsong Sheng
Publikováno v:
Proceedings of the National Academy of Sciences. 112:7073-7078
Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a123eaa8b0d554706200c77e160fb675
https://doi.org/10.1073/pnas.1500791112
https://doi.org/10.1073/pnas.1500791112
Publikováno v:
Trends in Molecular Medicine. 22:919-921
To date, no antiviral agents have been approved for treating Zika virus (ZIKV) infection. Two recent drug-repurposing studies published in Cell Host & Microbe and Nature Medicine demonstrated that screening FDA-approved drugs for antiviral activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea7204fb61085963e3b6a23d7b749ed
https://doi.org/10.1016/j.molmed.2016.09.006
https://doi.org/10.1016/j.molmed.2016.09.006
Autor:
Holly M. Scott Algood, Arwen E. Frick-Cheng, Christian González-Rivera, Timothy L. Cover, Jana N. Radin, Donald H. Rubin, Jinsong Sheng, Jennifer A. Gaddy, Mark S. McClain
Publikováno v:
Infection and Immunity. 82:423-432
Helicobacter pylori colonizes the human stomach and confers an increased risk for the development of peptic ulceration, noncardia gastric adenocarcinoma, and gastric lymphoma. A secreted H. pylori toxin, VacA, can cause multiple alterations in gastri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c963ceec929539a43b02abc83cd1a4
https://doi.org/10.1128/iai.00827-13
https://doi.org/10.1128/iai.00827-13
Autor:
Michael W. Shaw, Natallia Dziuba, Andrew Prussia, Natalie J. Mcdonald, Jinsong Sheng, Guangyu Li, William A. O'Brien, James L. Murray, Donald H. Rubin, Anthony Sanchez, Brian M. Friedrich, Thomas W. Hodge, Monique R. Ferguson
Publikováno v:
AIDS Research and Human Retroviruses. 28:1329-1339
Cellular proteins are essential for human immunodeficiency virus type 1 (HIV-1) replication and may serve as viable new targets for treating infection. Using gene trap insertional mutagenesis, a high-throughput approach based on random inactivation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4daf39137ef3a747def19c6a79bc57
https://doi.org/10.1089/aid.2011.0358
https://doi.org/10.1089/aid.2011.0358
Autor:
William A. O'Brien, Donald F. Smee, Michael W. Shaw, James L. Murray, Natalie J. Mcdonald, Donald H. Rubin, Thomas W. Hodge, Jinsong Sheng
Publikováno v:
Antiviral Chemistry and Chemotherapy. 22:205-215
Background: Host genes serving potential roles in virus replication may be exploited as novel antiviral targets. Methods: Small interfering RNA (siRNA)-mediated knockdown of host gene expression was used to validate candidate genes in screens against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c187fd7d11b2ba47f5f2c0dcad24ded
https://doi.org/10.3851/imp2080
https://doi.org/10.3851/imp2080
Autor:
Marilyn Sutcliffe, James O. Price, Christopher D. Nalbantyan, Edward L. Organ, Stephen C. Woodward, Raymond N. DuBois, Jinsong Sheng, Robert J. Coffey, Lillian B. Nanney, Donald H. Rubin
Publikováno v:
DNA and Cell Biology. 23:430-441
We have utilized growth factors in in vitro and in vivo systems to examine the role of cellular proliferation in reovirus replication. In vitro, proliferating RIE-1 cells can be infected with whole reovirus virions, but are relatively resistant to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be726ea2d2056226e342ba7e30ecadea
https://doi.org/10.1089/1044549041474751
https://doi.org/10.1089/1044549041474751