Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Donald H. Maurice"'
Autor:
Paulina Brzezinska, Donald H. Maurice
Publikováno v:
Cells, Vol 8, Iss 12, p 1473 (2019)
Pharmacological activation of protein kinase A (PKA) reduces migration of arterial smooth muscle cells (ASMCs), including those isolated from human arteries (HASMCs). However, when individual migration-associated cellular events, including the polari
Externí odkaz:
https://doaj.org/article/ff3e2594a15e480bb08c3e512ba0dac3
Autor:
Ruaa Al-Qazazi, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins, Stephen L. Archer
Publikováno v:
American journal of respiratory and critical care medicine. 206(5)
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may promote RVF in PAH. O
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:179-184
Human arterial endothelial cells (HAECs) regulate their phenotype by integrating signals encoded in the frictional forces exerted by flowing blood, fluid shear stress (FSS). High laminar FSS promotes establishment of adaptive HAEC phenotype protectiv
Autor:
L. Rhiannon Hilton, Jodi L. MacKeil, Jeffrey Mewburn, Paula D. James, Devon V. Cole, Mark L. Ormiston, Donald H. Maurice, Anne L. Theilmann, Mara K.M. Whitford, Lindsey G. Hawke, Kimberly J. Dunham-Snary, Stephen L. Archer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Pulmonary arterial hypertension is a disease of proliferative vascular occlusion that is strongly linked to mutations in BMPR2—the gene encoding the BMPR-II (BMP [bone morphogen
Objective: Pulmonary arterial hypertension is a disease of proliferative vascular occlusion that is strongly linked to mutations in BMPR2—the gene encoding the BMPR-II (BMP [bone morphogen
Autor:
Fei Chen, Mitchell de Prinse, Donald H. Maurice, Ta Phung, Jonah Burke-Kleinman, Sara Mohajeri, Brian G. Amsden
Publikováno v:
Molecular Pharmaceutics. 17:1363-1376
Liquid, injectable hydrophobic polymers have advantages as degradable drug delivery vehicles; however, polymers examined for this purpose to date form acidic degradation products that may damage acid-sensitive drugs. Herein, we report on a new viscou
Autor:
Sara, Mohajeri, Fei, Chen, Mitchell, de Prinse, Ta, Phung, Jonah, Burke-Kleinman, Donald H, Maurice, Brian G, Amsden
Publikováno v:
Molecular pharmaceutics. 17(4)
Liquid, injectable hydrophobic polymers have advantages as degradable drug delivery vehicles; however, polymers examined for this purpose to date form acidic degradation products that may damage acid-sensitive drugs. Herein, we report on a new viscou
Autor:
Jeffrey Mewburn, Lindsey G. Hawke, Stephen L. Archer, M. Bowman, Soundarya N. Selvam, Lara J. Casey, Donald H. Maurice, Paula D. James, Avery J. Longmore, Mark L. Ormiston
Publikováno v:
Blood Coagulation & Fibrinolysis. 28:521-533
Bleeding associated with angiodysplasia is a common, often intractable complication in patients with von Willebrand disease (VWD). von Willebrand factor (VWF), the protein deficient or defective in VWD, is a negative regulator of angiogenesis, which
Publikováno v:
Cellular Signalling. 36:204-211
Cyclic GMP (cGMP) translates and integrates much of the information encoded by nitric oxide (NO·) and several natriuretic peptides, including the atrial natriuretic peptide (ANP). Previously, we reported that integration of a cGMP-specific cyclic nu
Autor:
Christopher J. Nicol, Donald H. Maurice, Jonah Burke-Kleinman, Paulina Brzezinska, Jodi L. MacKeil, Mark L. Ormiston, Anne L. Theilmann
Publikováno v:
Cellular signalling. 62
Recent reports show that protein kinase A (PKA), but not exchange protein activated by cAMP (EPAC), acts in a cell autonomous manner to constitutively reduce the angiogenic sprouting capacity of murine and human endothelial cells. Specificity in the
Autor:
Andrew W.B. Craig, Jodi L. MacKeil, Donald H. Maurice, Paulina Brzezinska, Christopher J. Nicol, Jonah Burke-Kleinman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Angiogenic sprouting can contribute adaptively, or mal-adaptively, to a myriad of conditions including ischemic heart disease and cancer. While the cellular and molecular systems that regulate tip versus stalk endothelial cell (EC) specification duri