Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Donald G. Osinga"'
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Prevention of human leukocyte elastase-mediated lung damage by 3-alkyl-4-azetidinones
Autor: Daniel S. Fletcher, M.Ellen Dahlgren, Bonnie M. Ash, Philip Davies, Conrad P. Dorn, Donald G. Osinga, H. Weston, Shrenik K. Shah, R. J. Bonney, Pau.E. Finke, Pam S. Dellea, Jeffrey J. Hale, William K. Hagmann, Karen A. Brause, Kevan R. Thompson, Karen M. Hand, Alan L. Maycock, James B. Doherty, Laura A. O'Grady
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 1:545-550
Simple 3-alkyl-4-azetidinones have been previously reported as potent inhibitors of human leukocyte elastase (HLE). Further modification of these simple monocyclic β-lactams has led to development of substituted 4-azetidinones that both inhibit HLE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c2e5dd4773968a0e79fe011922e132
https://doi.org/10.1016/s0960-894x(01)80463-7
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3
A Comparison of α1-Proteinase Inhibitor Methoxysuccinyl-Ala-Ala-Pro-Val-Chloromethylketone and Specific β-Lactam Inhibitors in an Acute Model of Human Polymorphonuclear Leukocyte Elastase-induced Lung Hemorrhage in the Hamster
Autor: Donald G. Osinga, Paul E. Finke, William K. Hagmann, Philip Davies, Daniel S. Fletcher, Pam S. Dellea, Karen M. Hand, Richard A. Mumford, James B. Doherty, R. J. Bonney, Bonnie M. Ashe
Publikováno v: American Review of Respiratory Disease. 141:672-677
A pharmacokinetic model is described for testing of polymorphonuclear leukocyte (PMN) elastase inhibitors administered by intratracheal or aerosol dosing of hamsters. Acute lung injury, measured as hemorrhage occurring within hours after intratrachea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27824b6dc1ccb8aa8818210f02cece0a
https://doi.org/10.1164/ajrccm/141.3.672
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4
Role of polymorphonuclear leukocytes in connective tissue breakdown during the reverse passive arthus reaction
Autor: Daniel S. Fletcher, R. J. Bonney, Donald G. Osinga
Publikováno v: Biochemical Pharmacology. 35:2601-2606
The reverse passive Arthus (RPA) reaction performed in the skin of rats was modified to allow for the determination of polymorphonuclear leukocyte (PMN) infiltration and hemorrhage, as well as changes in vascular permeability. After initiation of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e803a2988e290251c541ecbafa03045e
https://doi.org/10.1016/0006-2952(86)90059-6
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5
Pharmacological profile of the substituted beta-lactam L-659,286: a member of a new class of human PMN elastase inhibitors
Autor: Karen M. Hand, L. Schaeffer, Donald G. Osinga, Alan L. Maycock, Paul E. Finke, Richard A. Mumford, P. Davies, Pam S. Dellea, David Fletcher, C. P. Dorn, R. J. Bonney, T. Nolan, D. Frankenfield, Shrenik S. Shah, William K. Hagmann, Bonnie M. Ashe, James B. Doherty
Publikováno v: Journal of cellular biochemistry. 39(1)
Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659,286 (7 alpha-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4- triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo[4.2.O]oct-2-ene -2- pyrrolidine carboxamid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34302358871b8555e31fd3230612138
https://pubmed.ncbi.nlm.nih.gov/2497109
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