Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Donald G. Guiney"'
Autor:
Donald G. Guiney, Joshua eFierer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)
Salmonella strains cause three main types of diseases in people: gastroenteritis, enteric (typhoid) fever, and non-typhoid extra-intestinal disease with bacteremia. Genetic analysis indicates that each clinical syndrome requires distinct sets of viru
Externí odkaz:
https://doaj.org/article/173821836bf9420593d217c4ec8bd5ee
Autor:
Nina M van Sorge, Celia M Ebrahimi, Shauna M McGillivray, Darin Quach, Mojgan Sabet, Donald G Guiney, Kelly S Doran
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2964 (2008)
Anthrax meningitis is the main neurological complication of systemic infection with Bacillus anthracis approaching 100% mortality. The presence of bacilli in brain autopsies indicates that vegetative bacteria are able to breach the blood-brain barrie
Externí odkaz:
https://doaj.org/article/72d24065d4ff40ae86b5179ba2a9a976
Autor:
Ronald R. Marchelletta, Joshua Fierer, Sharon Okamoto, Mélanie G. Gareau, Kim E. Barrett, Donald G. Guiney
Publikováno v:
The Journal of infectious diseases, vol 212, iss 1
Background. Gastroenteritis is the most common manifestation of nontyphoidal Salmonella enterica infections, but little is known about the pathogenesis of diarrhea in this infection Methods. To determine whether polymorphonuclear neutrophils (PMNs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07346818d3526f2a74d3830044243ed
https://doi.org/10.1093/infdis/jiu829
https://doi.org/10.1093/infdis/jiu829
Publikováno v:
Journal of Clinical Microbiology. 50:3598-3603
Recurrent invasive nontyphoidal Salmonella (NTS) infection is an AIDS-defining illness that has become less common in the developed world in the era of highly active antiretroviral therapy (HAART), while it has emerged as a major public health proble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe74551bef428ae11e0cfb4c5b09e2b
https://doi.org/10.1128/jcm.00795-12
https://doi.org/10.1128/jcm.00795-12
Publikováno v:
Infection and Immunity. 80:3360-3370
We investigated the roles of Salmonella pathogenicity island 2 (SPI-2) and two SPI-2 effectors in Salmonella colitis and diarrhea in genetically resistant BALB/c.D2 Slc11a1 congenic mice with the wild-type Nramp1 locus. Wild-type Salmonella enterica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3789ee288c589b709ff1f7055736c0b
https://doi.org/10.1128/iai.00404-12
https://doi.org/10.1128/iai.00404-12
Autor:
Brett Bowman, Donald G. Guiney, Christopher H. Woelk, Sandro Vivona, Paul R. McAdam, Tiffany Q. Luong, Richard K. Belew, Jin X. Zhang, Joshua Fierer, Harpal Sahota, Faramarz Valafar
Publikováno v:
Vaccine. 29:8156-8164
Reverse vaccinology aims to accelerate subunit vaccine design by rapidly predicting which proteins in a pathogenic bacterial proteome are putative protective antigens.Support vector machine classification is a machine learning approach that has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae472e9674284886a9296262ab48df02
https://doi.org/10.1016/j.vaccine.2011.07.142
https://doi.org/10.1016/j.vaccine.2011.07.142
Publikováno v:
Helicobacter. 16:398-404
Background: Helicobacter pylori is a spiral-shaped Gram-negative microaerophilic bacterium associated with a number of gastrointestinal disorders, including gastritis, peptic ulcers, and gastric cancer. Several studies have implicated a Th17 response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7756b452a664ac7ac9c9cbd25c0ea3
https://doi.org/10.1111/j.1523-5378.2011.00861.x
https://doi.org/10.1111/j.1523-5378.2011.00861.x
Autor:
Kelly S. Doran, Donald G. Guiney, Patricia A. Zialcita, Darin Quach, Nina M. van Sorge, Sara H. Browne
Publikováno v:
The Journal of Infectious Diseases. 203:401-405
Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e364e3eb628811fe22fbbb23409b719
https://doi.org/10.1093/infdis/jiq048
https://doi.org/10.1093/infdis/jiq048
Autor:
Paul A. Insel, Patricia A. Valdez, Eyal Raz, Joshua Fierer, José M. González-Navajas, Sandip K. Datta, Nicholas J. G. Webster, Mojgan Sabet, Kim Phung Nguyen, Shamima Islam, Ivan Mihajlov, Donald G. Guiney
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10638-10643
Cholera toxin (CT) elicits a mucosal immune response in mice when used as a vaccine adjuvant. The mechanisms by which CT exerts its adjuvant effects are incompletely understood. We show that protection against inhalation anthrax by an irradiated spor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e6b3ff788b7952c2c35322931305ae
https://doi.org/10.1073/pnas.1002348107
https://doi.org/10.1073/pnas.1002348107
Autor:
Russel Dahl, Maurizio Pellecchia, Elisa Barile, Jesus Vazquez, Donald G. Guiney, Marilisa Leone, Angel Mei
Publikováno v:
Chemical Biology & Drug Design. 76:10-16
We describe the use of a furanyl salicyl nitroxide derivative (‘spin-labeled’ compound), as a paramagnetic phosphotyrosine mimetic, to carry out a second-site screening by NMR against the PTPase YopH from Yersinia pestis. Using such a fragment-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2dec1c7fb1e50e348fa57435c606d20
https://doi.org/10.1111/j.1747-0285.2010.00982.x
https://doi.org/10.1111/j.1747-0285.2010.00982.x