Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Donald G Raible"'
Autor:
Unnur S Bjornsdottir, Stephen T Holgate, Padmalatha S Reddy, Andrew A Hill, Charlotte M McKee, Cristina I Csimma, Amy A Weaver, Holly M Legault, Clayton G Small, Renee C Ramsey, Debra K Ellis, Conor M Burke, Philip J Thompson, Peter H Howarth, Andrew J Wardlaw, Phillip G Bardin, David I Bernstein, Louis B Irving, Geoffrey L Chupp, George W Bensch, Gregory W Bensch, Jon E Stahlman, Monroe Karetzky, James W Baker, Rachel L Miller, Brad H Goodman, Donald G Raible, Samuel J Goldman, Douglas K Miller, John L Ryan, Andrew J Dorner, Frederick W Immermann, Margot O'Toole
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21902 (2011)
Asthma exacerbations remain a major unmet clinical need. The difficulty in obtaining airway tissue and bronchoalveolar lavage samples during exacerbations has greatly hampered study of naturally occurring exacerbations. This study was conducted to de
Externí odkaz:
https://doaj.org/article/f4ed057e1067408a9023f1d201f1a2b4
Autor:
Simon Zhou, Cathye Shu, Joseph Wadjula, Joan M. Korth-Bradley, Maria Palmisano, Thorir D. Bjornsson, Donald G. Raible, Saeed Fatenejad
Publikováno v:
The Journal of Clinical Pharmacology. 51:864-875
Etanercept pharmacokinetics in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriasis were assessed separately with distinct models using population pharmacokinetics methods of limited precision. The different model struc
Publikováno v:
Pharmacotherapy. 28:895-905
Study Objective. To evaluate the potential for a clinically significant drug interaction between tigecycline and warfarin by using pharmacokinetic and anticoagulant assessments. Design. Open-label, nonrandomized study. Setting. Inpatient clinical pha
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:220-229
Tigecycline, a novel glycylcycline antibiotic, exhibits strong activity against gram-positive, gram-negative, aerobic, anaerobic, and atypical bacterial species, including many resistant pathogens, i.e., vancomycin-resistant enterococci, methicillin-
Publikováno v:
Clinical & Experimental Allergy. 31:1631-1635
Background The study of gene expression from human lung mast cells (HLMC) has been limited by the ability to reliably detect mRNA transcripts from scant quantities of mast cell RNA contaminated with heparin. Objective As heparin is granule-associated
Autor:
Thomas J. Post, Yihe Wang, Joseph H. Butterfield, Mark C. Glaum, Donald G. Raible, Jonathan S. Jaffe, Edward S. Schulman
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 15:473-481
Using reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), we studied the generation of the recently described Th2 cytokine interleukin-13 (IL-13) by anti-IgE-activated lung fragments (LF), lung mast
Autor:
Jonathan S. Jaffe, Edward S. Schulman, Yihe Wang, Donald G. Raible, Thomas J. Post, Edward Dimitry, Mark C. Glaum, Dinesh Govindarao
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 13:665-675
The late-phase of allergic asthma is characterized by infiltration of the airway with eosinophils within 6 h of mast cell activation. Pro-eosinophilic/pro-allergic (TH2) cytokines, originally described as T-lymphocyte products, have recently been asc
Autor:
Yihe Wang, Edward Dimitry, Jonathan S. Jaffe, Mark C. Glaum, Edward S. Schulman, Thomas J. Post, Donald G. Raible, David Gillespie
Publikováno v:
Clinical Immunology and Immunopathology. 75:171-178
mRNA and protein expression of the Th2 cytokines IL-4 and IL-5 from human lung were examined during the first 4 hr following IgE-mediated triggering, a time representative of the evolving late-phase reaction (LPR). Lung explants were incubated for 16
Autor:
Donald G. Raible
Publikováno v:
Journal of Leukocyte Biology. 56:65-73
There has been considerable interest in the role of eosinophils in the pathogenesis of asthma and allergic diseases. While examining the conditions necessary for the release of leukotriene C4 (LTC4) from human eosinophils activated by immunoglobulin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 149:1506-1511
There is increased recognition that lung mast cell mediators not only produce the symptoms of acute asthma, but also result in the recruitment and activation of additional proinflammatory cells, such as eosinophils. Histamine, one of the major mast c