Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Donald G, Moerman"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 11, Pp 3977-3990 (2020)
Externí odkaz:
https://doaj.org/article/966d74af5c4743fc8d909e073ac4d585
Autor:
Erica Li-Leger, Richard Feichtinger, Stephane Flibotte, Heinke Holzkamp, Ralf Schnabel, Donald G Moerman
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractIt has been estimated that 15%–30% of the ∼20,000 genes in C. elegansC. elegans
Externí odkaz:
https://doaj.org/article/0fe2d2f1a70344fb93591fd6fb0a6875
Autor:
Vinci Au, Erica Li-Leger, Greta Raymant, Stephane Flibotte, George Chen, Kiana Martin, Lisa Fernando, Claudia Doell, Federico I. Rosell, Su Wang, Mark L. Edgley, Ann E. Rougvie, Harald Hutter, Donald G. Moerman
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 135-144 (2019)
The Caenorhabditis elegans Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date, approximately 15,000 ORFs have associated putative null alleles. As ther
Externí odkaz:
https://doaj.org/article/38f38c20093b4e3ab2a414f3efc28908
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238950 (2020)
Improved genome engineering methods that enable automation of large and precise edits are essential for systematic investigations of genome function. We adapted peel-1 negative selection to an optimized Dual-Marker Selection (DMS) cassette protocol f
Externí odkaz:
https://doaj.org/article/f0cebc28659b427cbe8025590b05f26a
Autor:
James L. Lissemore, Elyse Connors, Ying Liu, Li Qiao, Bing Yang, Mark L. Edgley, Stephane Flibotte, Jon Taylor, Vinci Au, Donald G. Moerman, Eleanor M. Maine
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1535-1544 (2018)
In a genetic screen to identify genes that promote GLP-1/Notch signaling in Caenorhabditis elegans germline stem cells, we found a single mutation, om40, defining a gene called ego-3. ego-3(om40) causes several defects in the soma and the germline, i
Externí odkaz:
https://doaj.org/article/8326c981e61f43f4ba0ad6608c53df23
Autor:
Komal Safdar, Anniya Gu, Xia Xu, Vinci Au, Jon Taylor, Stephane Flibotte, Donald G. Moerman, Eleanor M. Maine
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2125-2134 (2016)
Notch-type signaling mediates cell−cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is associated with various developmental defects and disease states, including cancers. Caenorhabdit
Externí odkaz:
https://doaj.org/article/22bbd81bbed54f4ebc25ea463388d244
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 351-356 (2016)
Chromoanasynthesis is a recently discovered phenomenon in humans with congenital diseases that is characterized by complex genomic rearrangements (CGRs) resulting from aberrant repair of catastrophic chromosomal damage. How these CGRs are induced is
Externí odkaz:
https://doaj.org/article/e7f65930a3a24e34a461e8d58ccfe7fa
Autor:
Troy A. McDiarmid, Vinci Au, Aaron D. Loewen, Joseph Liang, Kota Mizumoto, Donald G. Moerman, Catharine H. Rankin
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic variation we discover. This presents a major challenge in the clinical setting, where the recent application of whole-exome and whole-genome sequencing has unco
Externí odkaz:
https://doaj.org/article/4d19cfd57e27424a95ab8cf6388ff215
Autor:
Tatiana, Maroilley, Stephane, Flibotte, Francesca, Jean, Victoria, Rodrigues Alves Barbosa, Andrew, Galbraith, Afiya Razia, Chida, Filip, Cotra, Xiao, Li, Larisa, Oncea, Mark, Edgley, Donald G, Moerman, Maja, Tarailo-Graovac
Publikováno v:
Genome research.
Genetic balancers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::226a1d6ff8cb577b839f4f58e2f743f5
https://pubmed.ncbi.nlm.nih.gov/36617680
https://pubmed.ncbi.nlm.nih.gov/36617680
Autor:
Tiffany A Timbers, Stephanie J Garland, Swetha Mohan, Stephane Flibotte, Mark Edgley, Quintin Muncaster, Vinci Au, Erica Li-Leger, Federico I Rosell, Jerry Cai, Suzanne Rademakers, Gert Jansen, Donald G Moerman, Michel R Leroux
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006235 (2016)
Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. R
Externí odkaz:
https://doaj.org/article/92ee75ab091a429ab63000dd1b802093